Cardiac glycosides. He aha ka mea?

Cardiac glycosides mea like i loko o Nine Inch 'ole i ka bile nāʻakika, cortisone, nā wikamina, hormones, naʻokoko. Mau waiwai i kona ano maoli metabolites mea e mālama 'o ka maʻamau functioning o ka naau.

Cardiac glycosides i haku o ka glucone (kō) a me ka aglycone. aglycone He ka hoomaopopo ana o ka lāʻau i loko o ka pharmacological ha awina. Komo i loko o naoh me nā hana 'ona e hōʻoiaʻiʻo unsaturated elima-Aupuni Lālā a ke komo lima i loko o kā lākou' ole.

Cardiac glycosides o nā'aʻaʻa a me nā loko i haawi unevenly. Pale umauma hoʻokahi kā lākou mau hana - ka myocardium, i accumulates wale 10% o ka hoʻomanaʻo, he hou 50% ua paa ia ma ka striated Muscle kahi ole i kekahi kanawai.

No ka mea lōʻihi like 'ole o ka hana o ka cardiac glycosides i māheleʻia i loko o:

- loa - digitoxin,

- waena - digoxin

- pōkole - strofantin, Korglikon.

Cardiac glycosides:ʻano papa hana o ka hana

Ma ka maʻamau moku'āina i loko o cardiomyocytes na 30 manawa hou potasiuma a me 20 mau manawa emi paʻakai. I koena, i ka pā ili o ka halepaahaoʻili lahilahi ua ikaika i hoopiiia, a me ka na - ma ka mea ku ole, mea io. Ma ka excitation kumuʻili lahilahi depolarization: paʻakai, a kalipuna komo i ka halepaahao. I loko o kēia kaʻina hana, ka potasiuma hiki ole kekahi, ma ka halepaahaoʻili lahilahi. A hiki ka mea, i hele mai mai loko mai o ka halepaahao, repolarization kaʻina huli no. Kēia manawa ia lŘlŘ e mamua i ka Muscle contraction. Penei, o ka nui o ka kalipuna hoʻolako ua paʻaʻia ka ho'ēmiʻana keena. Potasiuma Ion i koe i loko o ka halepaahao, e hakaka ana o ke kaʻina hana.

Cardiac glycosides wikiwiki i ka hoʻomaka 'ana o ka repolarization, a hoomakaukau i kā mākou hua o ka potasiuma cardiomyocytes. Ma hope o ka ka ho'ēmiʻana mea pono i ke koena o ka Ion, e hoihoi maloko, a mawaho o ka halepaahao (hoʻi auaiaea paʻakai a me ka potasiuma). Kēia kaʻina hana mea e kaukaʻi ma ka ikehu hookoe keena, mediated e ATP-ase'ūhū. Konaʻeleu paena - sulfhydryl pae. Cardiac glycosides aeie i kaʻeleu paena, hoemi i ka ha awina. A pau i kēia hiki aku ai i ka mea i paʻakai Ion noho i loko o ka halepaahao, a me keia hōʻeleu i ka hoouka kaua ana o ka mea e hiki mai ana depolarization. Inā ka maʻiʻo o ka potasiuma Ion, e emi me ka nui loa, me ka hoʻololi kemikala o creatine posapahate Ua wāwahiʻia, i hiki aku ai i ka ho'ēmiʻana ma ka mana o ka contraction o cardiac Muscle.

Cardiac glycosides: contraindications

Loa contraindications no kā lākou hana e: atrioventricular aeie II degere, sinus bradycardia, allergic reactions i mau ai ', intoxication ia.

No ka pili contraindications i na kēia: ciliary bradyarrhythmia, af-aeie au degere, maʻi sinus maʻi pale, coronary naau maʻi, sinus bradycardia, hypertension, naau, hypercalcemia, hypokalemia,ʻaʻa puʻuwai a pulmonary insufficiency mōʻaukala.

He 'ole e hoʻohana i ka cardiac glycoside i loko o ke ana ma lalo nei: amyloidosis o ka naau, diastolic naʻau ka leo overload ma aortic insufficiency, thyrotoxicosis, huʻi myocardial infarction, cardiomyopathy, constrictive pericarditis, naʻau ole me malamaia kiʻekiʻe cardiac auaiaea, anaemia, a no laila, ma luna o.

'Ana ia lakou iho contraindications aie a hiki i ka wa e kaawale aku o systolic dysfunction, a wehewehe i ka inefficiency o ka cardiac glycosides. A, no ka laʻana, i? Acaeoey o ka huʻi myocardial infarction, hoʻohana hiki hoʻonāukiuki ulu o arrhythmias, a haawi i ka poe ilihune prognosis no ka mea hou ke ola o ka hoʻomanawanui.

Ma mua o ke noi ana o cardiac glycosides e kukakuka pu me ka hoʻomalu. Kēia e kōkua pale aku i ka ulu ana o ka mea complications.