Immunoglobulin E a me kona physiological manaʻo nui

Immunoglobulin E a me kona physiological nui - nīnūnē e noi mai ana e noonoo. I keia manawa, loaʻa nō kekahi mau 'ano o nā immunoglobulins (nā mea'aʻaʻa). He nui na ano o nā mea'aʻaʻa e oko i loko o ke 'ano o ka hana a me keʻano papa hana o Anati-infective e hoʻonele. Nā mea'aʻaʻa hoʻonāukiuki kimu a me flocculation o ka mea hoʻoheheʻe mea koʻohune huahana, agglomeration a me ka agglutination corpuscular antigens (spirochetes, nā mea hoʻomaʻi, protozoa a me koʻohune). Ma ka halepaahaoʻili lahilahi vibrios trypanosomes a paa spirochetes immunoglobulins ho'ākāka pono me ka hoʻokō, ma o na la platelet adsorption. Nō kāu, e hoopaa iho i kēia mau infectious Luna ma ka lymphoid'aʻaʻa. Nā immunoglobulins o nā papa G a me M pu me ka hoʻokō hiki hydrolyze spirochetes, trypanosomes, koʻohune a me nā mea hoʻomaʻi.

Ua kaulia ana hopena o nā mea'aʻaʻa ma ka pathogen ka wā e komo i ka halepaahao, a i ka haʻiʻana i ka antigen ma luna o ka halepaahao ili honua. Immunoglobulins ke hoʻoikaika a hoonawaliwali i ka'ōnaehana paleʻea ia'ku o ka meaola. Antigen-lāʻau lapaʻau kino eiiieaena a iloko ona i kakauia na antigen oi, hanaʻia i ka noho haumāna kahi kanawai, a me ka luna 'me ka oi o nā mea'aʻaʻa kumu no ke ku pono hopena. Loa pinepine, na immunoglobulins i ke kumu o ka autoimmune a me ka allergic complications.

IgE ua synthesizedʻano nui i loko o na keena o ka mucous membranes o ka ÷ naehana hanu, gastro-intestinal'āpana, e like me ma ka 'āina' lymph aka wahi. No ka manawa mua, e like me ka papa kaawale o ka immunoglobulin E i hōʻike 'ia ma 1966, a ma ka makahiki 1968, ka MEA ua ike like kuokoa IgE papa o immunoglobulins.

keia papa o nā polokina loaʻa i loko o kānaka, primates a me kekahi keʻena hoʻokolohua holoholona. Ka hapa nui o ka E immunoglobulin nā lātoma ua hoʻopili i ka ili kia keena a me basophils. No ka mea, ma lalo o maʻamau rula immunoglobulin E nā hoʻohui like i loko o ke koko lāʻau lapaʻau o kekahi mau nanograms no mililika me, ka walaʻauʻana manaʻo o ka 'ole o kēia lātoma ua loaa wale ma luna o ka muli o ke ao ana o kekahi mau myeloid nā polokina. Loa haʻahaʻa pae o ka immunoglobulin E ma ka lāʻau lapaʻauʻae nō hoʻi kupu ana mai o ka mea ia ia ka hiki mai o "o Laielohelohe" a hiki i ka ili o na keena, a paa hoopaa i kia keena a me basophils.

Ua Ua manaoio ia Іg E o ka nui papa o immunoglobulins i paka kia keena, a basophils e komo i loko o allergic reactions. Ka nui o keia kumuʻiʻo ma ka lāʻau lapaʻau o nā mea maʻi me ka allergy, piʻi pū, a IeAUPIIe, IAa IO aku i 350-800 U / mg. Total IgE kona kūmau i na keiki ma lalo o ka makahiki o 12 mahina i ka 15 U / ml. IgE Radio nui i kūlana ma ka reactions o koke hypersensitivity. Immunoglobulin E kūmau i loko o nā mākua ka ÷ 0 a hiki i 120 U / ml.

E like me ke kālā no manaÿo, i ke kumu nui o ka hana immunoglobulin E mea e hoʻopale ai i ke kino o mucous membranes aie i ka ho'ā hope o kūloko aʻe o ke koko wai koko a me ka effector keena. e hiki ke hemo mai ma ka 'ohana ka palekana laina e hoolilo immunoglobulins o ka papa A. Ma hope iho i nā mea hoʻomaʻi paha koʻohune ma ka ili o ke kia keena hoopaa ana i kekahi immunoglobulin E ka papa, e like me ka hopena o ia AaOIeIOUIeXAOAaIN kia aeee loaa i ka hoailona, e kuu ana i vasoactive amines a me chemotactic aʻe, Pathogens i ka huli, lalau mai inflow o ai hoʻolahaʻia IG ka papa o ka G, hoʻokō, eosinophils a me neutrophils. Eosinophilic chemotactic ololi, a ua hookuu mai kia keena, ka paipai 'ana i ka hoʻomāhuahua o eosinophils a me ka make ana o ka ilo. Ua Ua manaoio aku i ka IgE adsorbed ma luna o ka ili o ka parasite,,ʻo macrophages hoomaikai i FC-receptors.