Anticoagulants kauoha a me kaʻauhau'ēʻaʻe hana. ʻauhau'ēʻaʻe anticoagulants: i ka papa inoa o ka ai ', keʻano papa hana o ka hana, Mea Maluna. Overdoseʻauhau'ēʻaʻe anticoagulants

Me ka mea kupono functioning o coagulation a me ke koko nenoai antisvertyvayuschey normalization o ka na koena o ke kino. koko ma na moku aʻole i nā pale kaʻa a me nā palena, a me ka thrombus ho okumu ma ka pololei kiʻekiʻe. A i ke koena ua nee functioning o nenoai i loko o ka lokomaikai o ka ho'ā hope o ke koko coagulation, eia aku ana e hiki alakai i excessive ho okumu ana o clots. ʻauhau'ēʻaʻe anticoagulants - kekahi o nā pūʻulu o ai 'ia no ka loaa ana o na kāna hana.

He aha nā anticoagulants?

Anticoagulant kapaia dala, a i anticoagulant keia, a haʻalele no ka dilution o ke koko. Ua apono 'oe, e hoihoi i ka rheological' ano a me ka emi thrombosis.

Loa i loaʻa ma ka papa palapala, e like me ka hinu, gels a me ka pahu kui hoomakaukau. Ka mea, e hāʻawi ole wale no ka hana maikaʻi maʻi, akā, no hoi, e pale loa ho okumu ana o ke koko clots.

Ka hapanui o na lala o keia pae ana o ai 'ka mea,ʻaʻole i hana thrombus, a me clotting aayoaeuiinoe. Ke kaʻina hana o ka waiū i ka wai koko kumumea, a me ka? Iecaianoaaiiie o thrombin, a 'aʻole hoʻi ia i ke koko clots.

Ai 'i maheleia i mau pūʻulu e like me kā lākou hana:

• pololei anticoagulants;
• ʻauhau'ēʻaʻe anticoagulants.

kauoha hana o ka heparin-ka nānā 'ana ai'

Kēia pūʻulu o nā dala mai he pololei ia ma luna o ka wai koko cofactors i inhibit thrombin. I ka papa kuhikuhiE Luna mea heparin. Ma keia kumu, aia nō i ka nui o ka ai 'e hana like, a leokanipū i ka inoa:

• "Ardeparin".
• "Nadroparin."
• "Klivarin".
• "Longiparin".
• "Sandoparin".

Heparin a me nā mea loaʻa nakinaki i ka antithrombin-III, i hiki aku ai i ka loli i loko o ka wahi o kona nā lātoma. Kēia ka mämä holo i ka pili o ke cofactor no thrombin, a laila, e inactivate i ka clotting kaʻina.

Hiʻona o ka palapala noi "heparin"

Hana waiwai nona ma pale i ka ulu a me ka laha ana o ka koko clot. Heparin nā lātoma e hana i ka luna 'me ka antithrombin, a mea he inhibitor o coagulation kumumea. I ka waiwai o ka glycosaminoglycan kaulahao. Ka lāʻau 'Ua injected subcutaneously, a hoʻomaka kona hana ma hope o kekahi mau hola.

Inā pono, ka wikiwiki hana "Heparin" infusion lawelawe intravenously e hōʻeleu i hana, a hoonui bioavailability. Ke koho ana o ka lapaʻauʻia laʻau heluna hilinaʻi nui ma luna o ka moku'āina ma i ka hoʻomanawanui ka moana. A, ia i loko no o ka alo ana o concomitant maʻi, ia laua hooko ana o nā pūʻulu o medicaments, i ka pono no kaʻoki lāʻau lapaʻau kaʻina hana ma luna o na moku.

oligopeptides

Lapaʻauʻia e hana 'ana ma luna o ka piko o ka thrombin ho'ā hope, e manaoia ikaika ho'ākāka nā mea kūpale o thrombosis nenoaiu. Kaʻeleu 'Oponopono o ka lāʻau ma luna o lākou iho hoʻohui i ka clotting aʻe, huli hou ae la ko lakou conformation.

Kēia ka lapaʻauʻia "inogatran", "Hirudin", "Efegatran", "Tromstop" a me na mea e ae. Hoʻohana 'ia e pale ai ka naau ino o ka angina, varicose maʻi, no ka Kāohiʻana o ka thromboembolism, reocclusion i angioplasty.

ʻauhau'ēʻaʻe anticoagulants (papa)

Ke anticoagulant mua, ua loaa ia ma ka XX kenekulia i loko o ka United States, ia ia iʻike i ka hou maʻi o ka bipi wahine, e hoʻonāukiuki kaumaha kahe ana ke koko. A hiki aku i ke kumu i ua elucidated pathological ana, e hoao ia ia ma na holoholona iho mailoko me ka punahelu hana clover, Aia i loko o kaʻai. Mai keia maka mea i synthesized e ka mua lāʻau antiplateletʻauhau'ēʻaʻe hana - "Dicoumarol".

I ka lā, i ka papa inoa o ka waiwai i mea analogs o ka oi aku mamua o hookahi haneri mau. A pau o kēia mau ai '- ku una anticoagulants. Keʻano papa hana o ka hana o ka pae o ka ai 'ka nānā' ana ma luna o inhibition o ka hana o ka wikamina K.

Aia clotting kumumea e hilinaʻi ana ma keia wikamina. ʻauhau'ēʻaʻe anticoagulants inhibit ho'ā hope o ka coagulation nā polokina, a cofactors vitaminozavisimyh. Ke kipi 'ana o kēia mau ai' ua hookapuia, like no ka hana i ka pilikia o ke kahe ana ke koko complications.

Aia i ka papa kuhikuhiE pūʻulu elua, a i māheleʻia nā mea a pauʻauhau'ēʻaʻe anticoagulants. Mea Maluna o ka dala ua ka nānā 'ana ma luna hana' ona hui pū i loko o ka hoʻomākaukau. hoomaopopo:

• coumarin nā mea loaʻa;
• ka nānā 'ana i na mea paahana indandiona.

hoomakaukau indandiona

Ma hope o ka hooko ana mai i ka nui helu o nā haʻawina, nä känaka 'epekema i loaʻa i nā huahana me ka nānā' ana ma keia hana waiwai ole e e ia i loko o Inc. Nā mea haʻilula keimikala i he nui ka helu o kaʻaoʻao waiwai like allergic reactions. I ka laulā o ka hopena ma luna o protivosvertyvaniya'ōnaehana no hoi i ole hōʻike pahuhopu nei hopena.

Kēia pūʻulu o ai 'nā ai', "phenindione", "Difenindion", "Anisindion". Ua Ua hooholoia e hooki i ka iniiaiie i waeʻia no ka lua o ka pūʻulu o antiplatelet Luna, a o nā mea loaʻa indandiona a ianoiyuaa a wale hoʻohana "Fenilin".

Ka lāʻau i ka haʻahaʻa lilo, ia mea i loaʻa i loko o papa palapala. Valid no ka 10 hola, a me ia mea nui, e malama i ka makemake lōʻihi like 'ole o ka Inc. Ke kanawai ua loaʻa wale nō ma hope o 24 hora, mai ka manawa o ka mahele lāʻau mua. Noi ia lŘlŘ ma ke kumu o ka mālamaʻana i keʻano o ka hoʻomanawanui Via i ke koko o ke keʻena hoʻokolohua kiko'î (coagulation, mau ho'āʻo ma, biochemistry).

Ke ano o ka 'fenilina ":

1. Ka mua lā - 1 papa 4 manawa.
2. I ka lua o ka lā - 1 papa 3 manawa.
3. Ke koena o ka iapaau ana - 1 papa no ka lā.

E e ia ka lapaʻauʻia me ka lapaʻauʻia i emi ai ka nui o ka monakō koko i loko o ke kino.

coumarin nā mea loaʻa

Coumarin - he waiwai i mea i kanu, a hiki ke hua mai synthetically i loko o ke keʻena hoʻokolohua. Mua, ma hope o kona ana, o ka mea paahana Ua hoʻohana i ka make no ka rodent hooponopono. Wale nō ka mea e hooholo ia o ka manawa i hoomaka ai e pili i ka lāʻau, e hana me ka excessive thrombosis.

Anticoagulants oʻauhau'ēʻaʻe hana - hoomakaukau ana ka nānā 'ana ma luna o coumarin - poe e ke kēia mau mea o ka lapaʻauʻia:

• "Warfarin" (kona analogues - "Marevan" "paʻakai Warfarin", "Varfareks").
• "Atsenokumarola" (mea like - "Sinkumar").
• "Neodikumarina" (mea like - "Etilbiskumatsetat").

"Warfarin": noi hiʻona

Anticoagulants oʻauhau'ēʻaʻe 'ana (ka papa mea i loaʻa i loko o ka' atikala) ua loa pinepine poe ma "Warfarin". Kēia 'o ia hoʻi papa, ua hanaʻia e 2,5, 3 a 5 mg. Kanawai i kanaka meaola e hoʻomōhala ana i hope 1.5-3 lā ma hope o ka hooponopono mua o ka papa. I kā mākou ia ma ka hopena o ka hebedoma mua.

Ma hope o ka lawe ana i ka lāʻau 'ka rheological kiko'î o ke koko hoi aku la i ka maʻamau ma hope o 5 mau lā, mai ka lā mai o ke kāpaeʻana "o ka warfarin." Loa hoʻi e hoʻohana 2 manawa i ka lā, i hoʻokahi a me ka ia manawa. Ma ka 5th lā o ka Inc e kéu koko kiko'î, e hooholo i ka feasibility a me ka hopenaʻoi loa.

I ka papa o ka lapaʻau ua wae mai ai hoʻomalu i loko o kēlā me kēia hihia pākahi. Kekahi maʻi Hawaii (e laʻa me, atrial fibrillation) e noi mai ana palapala noi. Me ka hooulu ana o PE (pulmonary embolism) antiplatelet Agena ua ole ia no ka emi o eono mahina a no ke ola.

A hiki aku i ka pono no kaʻoki lāʻau lapaʻau 'uao "Warfarin" e ana 5 mau lā ma mua o keʻoki kino. Kēia e ae i ke indices koko hoʻi i ka maʻamau. Me ke kiʻekiʻe nele no ka hoomau hoʻohana o anticoagulant Inc, o ka mea paahana ua auou caiaiai unfractionated heparin. Ka hope mahele lāʻau Ua lawelawe 4 hora mamua i ka 'uao.

Ma hope o hoohana ia ma 4 chasa reintroduced unfractionated heparin. Loaa anaʻauhau'ēʻaʻe antiplatelet Luna hiki ke hoi hou i loko o nā lā, ma hope o ka mālamaʻana i ka moku'āina o ke koko a me ke kōkua o ke keʻena hoʻokolohua ho'āʻo ma.

Ma i na hihia ua hoʻohana anticoagulants?

Direct a me kaʻauhau'ēʻaʻe anticoagulant hoʻohana no ka Kāohiʻana o ka thromboembolism, huʻi thrombosis o ka venous'ōnaehana i loko o ka hanana o ka me mechanical prosthetic naʻau kiwikā a me atrial fibrillation.

I ka papa kuhikuhiE maʻi ma ka ulu o ka i i ia anticoagulants kauoha a me kaʻauhau'ēʻaʻe hana, i ka i kēia mahele i loko o nā pūʻulu:

1. Thrombosis o ka arterial'ōnaehana:
   • myocardial infarction;
   • pulmonary embolism;
   • mapuna me symptoms o ka ischemia;
   • traumatic poino i arteries ku atherosclerosis.
2. Hoʻolaha intravascular coagulation :
   • hoohikilele Hawaii;
   • traumatic eha;
   • ka hooulu ana o ka sepsis.
3. Huʻi thrombosis o na aa koko ma:
   • koko clots ma ke kāʻei kua o varicose aa koko;
   • thrombosing hemorrhoidal venous plexus;
   • clot i loko o ka emi vena cava.

ka papa kuhikuhiE contraindications

ʻauhau'ēʻaʻe anticoagulants - ai 'i mea ikaika pāpā ma ke alo o lactose deficiency, malabsorption o ka monakō koko a me ka galactose. Aia nō i ka helu o ka ai 'i ka mea ia manawa e oe hiki ole hoʻohana ku una ha anticoagulants. Papa Inoa o ka ai 'oia hoi o nonsteroidal Anati-hoʻoʻino ai', "aspirin", "Dipyridamole", "clopidogrel", "Penicillin", "Chloramphenicol", "Cimetidine".

Nā kūlana i ole e hoʻohana 'hiki anticoagulants kauoha a me kaʻauhau'ēʻaʻe hana:

• ulcerative maʻi o ka gastrointestinal'āpana;
• vascular aneurysm;
• ake maʻi;
• huʻi kahe ana ke koko;
• thrombocytopenia;
• ʻaʻa puʻuwai ole;
• I trimester a me ka hope o ka malama o ka hāpai keiki;
• kiʻekiʻe pae o ka creatinine.

ʻaoʻao 'ole o antiplatelet Luna

Kēlā me kēia no ka ai 'ma keia pae o ka Luna he ano likeʻaoʻao ole. Ka mea, hoike mai ai ia lakou iho ma ka hoʻoponopono 'ole kūpono mahele lāʻau' ole 'aʻe' ana ma o ka hoʻohana a koi.

ʻaoʻao 'ole nā i ka hooulu ana o ke kahe ana ke koko, dyspeptic symptoms me ka luaʻi, nausea a me ka diarrhea. Aia He He ikaika abdominal eha, allergic ili poʻe noʻonoʻoʻole i keʻano o nā hives a eczema. E ulu necrosis, lauoho poho, ili maneo.

Mamua o hoʻomaka lapaau, i ka hoʻomanawanui pono kekahi, i ka moʻo o ka ho'āʻo e ike ai i ko, e hoʻohana i kēia mau ai '. Ke hoomanawanui e hoʻopakele i ka piha koko helu, biochemistry, urinalysis, mimi ma Nechiporenko, coagulation. Ua Ua hoi pono e hana i ultrasound ka ninaninau ana i na puʻupaʻa a me kekahi, noho no occult koko.

Overdoseʻauhau'ēʻaʻe anticoagulants

Overdoses o keia pae ana o ai 'i loa pohihihi keia. Kēia hiki hiki mai ina e hale he uuku keiki i ka lāʻau a me ka hoao ia no kaʻaiʻana. Nō kāu, i ka lehulehu o ka waiwai mea haʻahaʻa, no laila, i ka hookahi mahele lāʻau papa i ole makaʻu. I Ina o kūikawā a me unintentional hoʻohana a nui nā māhele o ka waiwai ke kūkulu i ka coagulopathy a me ka kahe ana ke koko.

overdose? aaieouʻAʻohe kekahi symptoms, no laila, koho i ka mea i hiki mai ai inu nui dala o ka lāʻau, ia mea pilikia. Symptomatology like hoikeana i loohia i kela a me pathological Hawaii o ka meaola. Ke hoomanawanui i:

• malamalama paopao koke mai oia ma kaʻili;
• ke koko ma ka mimi paha feces;
• uterine kahe ana ke koko;
• hematoma i loko o ka'ā'ī;
• intracranial hemorrhage.

Mua, mamua hahauʻana,ʻelemākule e hoʻomanawanui iki mai, gastrointestinal kahe ana ke koko, a me ka mōʻaukala o haʻahaʻa hematocrit - pili kumumea i hiki emi i ka susceptibility o ka paepae puka lehulehu o ka ai '.

Antiplatelet Inc overdose

1. Ua holoiʻia ai flushed ma ka'ōpū kekahi mau hola ma hope o aaieieno? O ai 'ʻaʻohe ano.
2. Ke hoomanawanui Ua haawiia ho'ā 'charcoal no intestinal omo.
3. "Cholestyramine" loko lawelawe ma ka hihia o "warfarin" overdose a me kona analogues.
4. Ke hoomanawanui Ua kau ma ka antitravmaticheskie ana, e pale aku i ka muli o hou hematomas a me hemorrhages.
5. Me ka lula 'koko poho paha transfusions lawe wai koko i hanaia hehee wale, i kekahi manawa a pau i ke koko. Efficient ma o ka hoʻohanaʻana i pihaʻulaʻula koko keena, cryoprecipitate, prothrombin eiiieaena.
6. I kauoha mai ai "Phytomenadione" huahana nānā 'ana i wikamina K.
7. Inā pono, hāʻawi i antiplatelet Inc, ka lāʻau "Phytomenadione" hoonoho papa o ka lapaʻau, ma mua me ke kokua mua.

Inā ke hoʻomanawanui i ka ke ano hoi i ka maʻamau, akā, he mea pono e hoʻomau i ka hoʻohana ku una ha anticoagulants, ia mea pono ia "Warfarin" hulina i puku ai 'heparin moʻo.

ka hopena

Ka hoʻohana a antiplatelet ai 'hiki ole wale normalize koko rheological mau hae, akā, no hoi, e hoʻoikaika' i ka nui ana o ka hoʻomanawanui, a pale i ka hooulu ana o ka maʻi kaumaha.

Akahele noonoo ana i ka hoʻohana 'ana o anticoagulants, i ka waeia o ka laʻau heluna a me ka mālamaʻana i ka hoʻomanawanui i ka ke ano hiki ke kōkua emi i ka pilikia o complications a me ka pomaikai. 'Oihana e hana i kēia pae o ka ai' i loko o kā lākou hana, Ua pono, e hoʻoikaika 'ana i kaʻike, a me ka hooko pololei me ka lahui ola koi.