Antidiuretic hōmona (ADH). Ke secretion o antidiuretic hōmona

Vasopressin - antidiuretic hōmona - hua mai la ma ka hypothalamus, i ua aia i loko o ka posterior pituitary (neurohypophysis). Kēia hōmona e hōʻoiaʻiʻo homeostasis i loko o ke kino o ke kanaka, ka malama ana i ka wai koena. No laila, no ka laʻana, dehydration paha papakaukau kahe ana ke koko ma lalo o ka aoao o ka vasopressin nā maomeka e hōʻoia 'ia ka cessation o ka loli lilo. Penei, ka antidiuretic hōmona (ADH) wale, aole ia i ae mai, e maloʻo.

Where ADH ua synthesized?

Antidiuretic hōmona hua mai la i ka nui aeea neurons o supraoptic nucleus o ka hypothalamus a me ka hoopaa ana i ka neyrofizinom (lawe-kumuʻiʻo). Eia, ka mea olelo i ka hope lobe o ka hypophysis, a malaila loaa i hypothalamic neurons. I pono, mai laila aku e komo i ke koko. ADH secretion ua loli ana ma:

1. Ke koko, (BP).
2. i ka wai koko osmolarity.
3. I ka buke o ke koko hoʻolahaʻia i loko o ke kino.

Liluwelo 'ole o Anati-diuretic hōmona

I ka kiʻekiʻe ke koko, secretion o antidiuretic hōmona uhi pū a conversely, hiki e mahuahua ai ka haule i loko o ke koko, ma ka 40% o ka maʻamau vasopressin hoʻololi kemikala, mai ka mau i kela la koi o ka 100 mau manawa.

ka wai koko osmolarity ua pololei e pili ana i ka electrolyte haku mele 'ana o ke koko. Once ka osmolarity o ke koko ma lalo o palena iki oluolu mau hae, hoomaka loa e auaaeaiea o vasopressin i loko o ke koko. Me ka hoomahuahua i ka wai koko osmolality ma luna o ka mea ana kūmau kanaka make wai. A hoʻohana o ka nui puuhuahelu o ka wai a suppresses ke kimu o ka hōmona. Penei, o ka hoomalu ua lawe mai ma ka dehydration.

Pehea antidiuretic hōmona ololi i ka loli i loko o ka buke o ka hoʻolahaʻia ke koko? Inā papakaukau koko poho kūikawā receptors aia i loko o ka atrium hema, a kapa aku la volyumoretseptorami pane i ka emi i loko o ke koko buke a me ke koko, kulu. Kēia neaiae komo ka neurohypophysis a me ka hou vasopressin, piʻi pū. Ka hōmona ka lawe ana i na moku ke koko a me kā lākou mau receptors narrows ka lumen. Kēia ka poʻea pau i ka cessation o ke kahe ana ke koko, a no hoi ua ālai 'i ke kulu i loko o ke koko,.

Aʻe 'ana o ka hoʻololi kemikala a me ka secretion o ADH

Mau kāna hana i ke pili me ka lawa helu o ka vasopressin a me kona ka liki ole. No ka laʻana, a me mimikō insipidus he mea he nui lawa o ADH, oiai maʻi pale Ioana Ion Parhon kona overabundance.

mimikō insipidus

Ma keia maʻi,ʻaʻa puʻuwai reabsorption o ka wai emi dramatically. Ua hiki e kōkua ai i nā e mau ka noho ana:

1. Kūpono 'secretion o vasopressin - ka wā e hele mai ai i mimikō insipidus o kikowaena kumu.
2. Hoemiia hakuʻala muli o ADH - kēia ka hana i ka wā i neurogenic ano o mimikō insipidus.

E hoomanawanui i loaa mai keia pathology kela la i keia diuresis e hiki 20 nā lika. Mimi ana haʻahaʻa-lehulehu. Hoʻomanawanui iki mai i mau wai a me ka mea inu i ka puu o ka loli. E loaʻa mai i ke ano o ka palapala o ke mimikō insipidus hoomanawanui poino, hana ka mea like no ka hōmona vasopressin - ka lāʻau "Desmopressin". Ka pākōlea hopena o ka lāʻau 'ua hoike mai ia ma ka kikowaena ano o ka maʻi wale.

maʻi pale ana i kūpono 'ole ka antidiuretic hōmona secretion

Ua ua i kapa maʻi pale ana i kūpono 'secretion o ADH. I ka maʻi ua pu ma excessive secretion o vasopressin, oiai e haule ana o ka hoemi osmotic puʻe o ke koko wai koko. Pela ka mea, i ka i kēia symptoms:

• Muscle twitching a me cramps.
• Nausea, nele o ka ikaika loa ka makemake, hiki ka luaʻi.
• Hiki lethargy, coma.

Hoʻomanawanui ano deteriorates ka wā i ke kino loli (intravenously 'ole i loko o ka inu). A hiki aku ka nui kapu o ka loliʻai ana a me ke kāpaeʻana intravenous infusion i loko o nā mea maʻi i loko o ke kala.

He aha symptoms hōʻike he lawa kiʻekiʻe o ka vasopressin?

Inā antidiuretic hōmona ua synthesized ma pokole lako, kanaka i ka mahina.

• Loa make wai.
• Pinepine urination.
• Dryness o kaʻili, a ua mau i holopono.
• Hoomaloka o kona'ōpū.
• Pilikia a me ka gastrointestinal'āpana (gastritis, colitis, constipation).
• Pilikia a me ka mea moe poepoe. Na kanaka - hoemi potency i loko o na wahine - menstrual kāna hana.
• Maʻi luhi.
• Hoomahuahua ae la lakou intracranial puʻe.
• Hoemiia hihio.

Ai hōʻikeʻia hoʻi i ka emi ana o ADH?

Ka ho'ēmiʻana i loko o ke koko vasopressin kānāwai i loko o ka kēia mau wahi, i hiki:

• Central mimikō insipidus.
• Nephrotic maʻi pale.
• Psychogenic polydipsia.

He aha e na symptomsʻoi i māhuahua secretion o ADH?

• Hoemiia kela la i keia diuresis (mimi? Iecaianoaaiiuo).
• Weight waiwai ma ka hoemiia kona'ōpū.
• Lethargy a me ka pōniuniu.
• Headaches.
• Nausea a me ka luaʻi.
• Muscle cramps.
• Ke Kula Kaiapuni 'lesions o ka'emi ko kahua.
• hiamoe ka haunaele.

Ma lalo o na hana hea ka nānā mau mea ulu i loko o ka iliwai o ADH?

I ka hua o ka vasopressin i e malama ia ma pathologies wehewehe aku ma excessive secretion o ka hōmona, e loaʻa:

• Julien-Barre maʻi pale.
• Intermittent huʻi porphyria.

Eia hou kekahi, he mea hiki ma lalo o ke ana ma lalo nei:

• loloʻeho (iniiaiie a metastases).
• Infectious maʻi o ka lolo.
• Vascular maʻi o ka lolo.
• Tuberculous meningitis.
• Pneumonia.

Antidiuretic hōmona - kahi hoihoi?

Kekahi o ka loa ka hoʻokō epekema no ka manao paa o ADH i loko o ke koko o ka radioimmunoassay (RIA). Ia laua, e hooholo i ke osmolarity o ke koko wai koko. Ka Ikepili hiki ke hana ia ma kekahi endocrinology waena. He nui a pilikino nā keʻena lāʻau lapaʻau i hana ia kālailai. Koko hana mai i kekahi aa koko i loko o paipu me kekahi preservatives.

Ma mua o haawi ana o ke koko a hiki i ka antidiuretic hōmona e e 10-12 hola anaʻe i loko o ka palaoa. Helu a me ka noʻonoʻo stress ma ka Ewa o ke koko donation hiki paha ka nānaina i ka Ka Ikepili. Kēia 'o ia hoʻi i ka lā ma mua haawi o ke Ka Ikepili ia mea pono,ʻaʻole e komo i loko o kaumaha physical hana,ʻaʻole e komo i loko o haʻuki Competition, mea,ʻaʻole e lawe me kŰia, etc.

Ai 'i ke hoomahuahua i ka nui o ADH, E haʻalele loaʻia. Inā keia mea,ʻaʻole e hiki i kekahi mea, ke noi pepa mea pono i ke koho 'ia ka lāʻau i hoʻohana', ka wā a ma ka mahele lāʻau. Paha ka nānaina i ka oiaio kiʻekiʻe o ADH ke ke kēia mau ai ':

• estrogens;
• e hiamoe ana huaale;
• anesthetics;
• tranquilizers;
• "Morphine";
• "Oxytocin";
• "Cyclophosphamide";
• "Carbamazepine";
• "Vincristine";
• "Hlorpropamid";
• "Chlorothiazide";
• "Likiuma kalepona".

Ka Ikepili o antidiuretic hōmona hiki e ia i mua o ka hebedoma kekahi ma hope o ka radioisotope a radiological noiʻi.

Kēia like apono 'mākou e differentiate nephrogenic mimikō insipidus a me ka pituitary mimikō insipidus a me syndromes wehewehe aku ma excessive secretion o ADH.