"Azathioprine": analogues, kumu kūʻai, alakaʻi a me ka hōʻike manaʻo

Autoimmune maʻi - he pūʻulu o pathological kumu ma i loaʻa ua mahuahua ha awina o ka'ōnaehana paleʻea'ōnaehana ia i kona kino iho. I mea e emi i ka'ōnaehana paleʻea pane, hoakaka ai 'e uhi i ka'ōnaehana paleʻea nenoaiu. Kēia pūʻulu o ka ai 'Ua paʻa mau ma ka transplantation e ole pakuiia auanei lakou rejection. E ka nana aku ma ia i ka lāʻau ', like me ka "Azathioprine" analogs o ka lāʻau, a me ka olelo ao no ka hoʻohana' ana o kona hiʻona.

pharmacological characterization

Ma kona kuleana o ka lāʻau "Azathioprine" kekahi mau i ka hana 'Oponopono o ka ia inoa. Kēia Nine Inch hui nei he derivative o na waiwai kupono no ka hoʻololi kemikala o ka DNA a me ka RNA. Ma ke kino, azathioprine haawi mai DNA hoʻololi kemikala, a, nolaila, inhibits aeea mahele keʻano o ka hanaʻana i loko o nā'aʻaʻa. Hoemi i ka ha awina o ka'ōnaehana paleʻea'ōnaehana, kena ae la ma ka aoao o ka lāʻau "Azathioprine" i loko o ka lymphoid'aʻaʻa.

Pela he mea inhibition o ka halepaahao mahele keʻano o ka hanaʻana a me ke kelepona hele'ōnaehana paleʻea pane. i ka hoike ana o "Azathioprine" hoomakaukau ia i loko o ke kino ma hope o ka'āno'ē ka ho'ēmiʻana i loko o ka helu ana o phagocytes, a hoemi immunoglobulin hoʻololi kemikala. E mai no hoi kālailai i ka 'ikepili: aha i na ano o ka "Azathioprine" lāʻau analogues, uku, olelo ao no ka hoʻohana.

Pharmacokinetics

Ka lāʻau 'Ua nui ka maiau paka i loko o ka systemic holo, a me kona i kā mākou lehulehu malamaia ma hope wale nō 2 hola ma hope o ku una hooponopono. Ke k mea i maopopo Trail i ka wai koko nā polokina: kona paa ia ia i ai i 30%. No ka azathioprine ano hopena iniiaiie metabolic ole mua, e hele ia ma ke akepaʻa.

Maalo ae la oia ma na hepatocytes, ka lāʻau ua metabolized i kaʻeleu hui - mercaptopurine, a i mea pharmacodynamic loa. Hoʻomanaʻo kokoke loa excreted me ka bile. Ka mimi excreted e ole aku ma mua o 2% o ka medicament.

nāʻikepili

E hoomakaukau ai "Azathioprine" analogues me ka iaʻeleu waiwai e hōʻike no ka hoʻohana i ka transplantation e pale aku pakuiia auanei lakou rejection naoh.

Nō hoʻi, i ka lāʻau ua kuleʻa hoʻohana 'ia i loko o rheumatological mea e hana rheumatoid arthritis a autoimmune maʻi e like me hepatitis, systemic lupus erythematosus, psoriasis, thrombocytopenic purpura, pemphigus, a he nui na mea e ae.

Contraindications

Uluwehi O "Azathioprine" ua contraindicated i loko o nā mea maʻi me ka hypersensitivity i ka lāʻau ke keʻena. Aie i ka mea i ka lāʻau inhibits a pau na germs o ke koko, "Azathioprine" ua contraindicated i loko o nā maʻi o ke koko (anaemia leykotsito- a me ka lymphopenia, thrombocytopenia), a oae? A hapai a me ka hanai nou.

E hoʻohana i hāpai keiki a me ka umauma-e ai ana

Kaʻeleu waiwai hele i loko o ka umauma o ka waiu a me ka ma gematoplatsentarny ke'ākeʻakeʻa mai. Ma keia manao, ua i waiho i ka hana ma ka hapai a me ka umauma-e ai ana. Inā pono, ke kohoia ana o ka lāʻau a me kona analogues i loko o kēia waeʻano o ka poe e pono e Loiloi i ka pilikia, mai ka hana ana o ka pono o ka lāʻau, a me ka Loaʻaʻia hoʻopōʻino i ka makuahine a me ka fetus. I ka ka lanakila konohiki i breastfeeding nei e ana.

Hiʻona o ka palapala noi

I ka lāʻau a me kona analogs pono ia e hoʻohana me ka mālama nui i loko o nā mea maʻi pilikia mai chickenpox, a me nā mea maʻi me ka deficiency o ka xanthine oxidase.

ʻaoʻao waiwai

I ka papa kuhikuhiE pūʻulu o kaʻaoʻao waiwai pili me ka inhibition o ka iwi a ka lolo hana, kuleana no ka? Iecaianoaaiiie oʻulaʻula koko keena. I ana analogs i loaʻa ka azathioprine, he mea ulu ma ka nui o aeee i loko o ke koko, ka ho'ēmiʻana o ka leucocyte helu, platelet helu, anaemia.

No ka hapa o ka mea digestive'āpana o ka loa e like me kaʻaoʻao mau waiwai ioiinyony: ua hoʻemi ikaika loa ka makemake, noho kāna hana, hoʻopōʻino hepatic hana, ulcerative lesions o ka gastrointestinal'āpana. Hiki lilo o hepatocytes, i ukali ia e ka mahuahua ma ka bilirubin 'ole' ē aʻe akepaʻa kuleana pili i ho'āʻo. Ma nā mea maʻi undergoingʻoki kino no ka hui, transplants a me'aʻaʻa i ulu pancreatitis, ulcerative lesions o ka opu, liʻiliʻi, e ulu ai o kaʻawahia hepatitis.

Allergic reactions ana loa kākaʻikahi ka wā lawelawe lāʻau "Azathioprine" analogs ka nānā 'ana ma luna o ka mea, (e laʻa me, "Azathioprine"). Hoike ana i kāheaʻia,ʻano nui ma muli o ka ili lapuwale ia a feverish Hawaii.

I waena o nāʻaoʻao 'ole e e hoʻomaopopo i ka hooulu ana o nā haumāna infectious keʻano o ka hanaʻana i loko o ke kino, i ka ikea ana o muscular a me ka olelo eha, huʻiʻaʻa puʻuwai ooieoeiiaeuiiai insufficiency. Ma kekahi hanahana loa hoopii, i ka lāʻau "Azathioprine" analogues me ka iaʻeleu waiwai hiki i hemolytic anaemia, e haawi ana symptoms mai ka Central ko mākou hopohopo nenoaiu. Azathioprine like me ka hana lāʻauʻeleu waiwai, he hapa o ka ia inoa lāʻau a me kona analogues, i ka hai ole ma ka fetus (teratogenic a mutagenic 'ole) a me ka hiki ana o ka hoʻonāukiuki i ka helehelena o kaʻeho keʻano o ka hanaʻana a me kā lākou mahope malignancy. Penei, ia mea e pono e nana i ke koho ana o ka lāʻau "Azathioprine" (papa) hōʻike manaʻo, nā wehewehena, lāʻau analogues a koho na nā kaʻa mokulele akau. E nana ana imua, ua hoailona oukou ia ia, e like me ka hana 'Oponopono azathioprine ka lawe pono' ole ma o ka holo ana o ka maʻi, e like me nāʻikepili. Keia ua hōʻike kauka ole wale akā, i nā mea maʻi ana ia lakou iho.

"Azathioprine" - synonyms, analogs

Azathioprine - kū hoʻokahi i loko o kona mau aoao i ka waiwai a me ka immunosuppressive hana. Ma nānaina o ka mea lāʻau lapaʻau market mea,ʻaʻole loa pono poe hoomakaukau i loaʻa azathioprine. Analogs "azathioprine" hiki ke hooku iho la ia i loko o ia i ka lāʻau ', like me ka "Azathioprine".

Ka lāʻau 'Ua loaʻa ma ka papa palapala me ka like maʻiʻo azathioprine. Ke wale nuance o ka waiwai e lilo aku ana o "Azathioprine" o ka lāʻau, a hiki i ka 4-5 manawa i ka waiwai e lilo aku ana o "azathioprine" Lūkini? Iecaianoaaiiuo.

Kaʻapu kōheoheo a me ka overdose

Uluwehi O overdose "Azathioprine" a me kona counterpart "Azathioprine" hoikea mai kāna hana o ka gastrointestinal'āpana, suppression o ka iwi ka lolo papa, e like me mahuahua akepaʻa kuleana pili i ho'āʻo. kaʻapu kōheoheo lapaau e like me ka lāʻau 'ia iho a me kona analogues mea symptomatic, nona ma ka māmā hoʻopau o ka lāʻau, mai ke kino. No kekahi antidote. Dialysis detoxification kāu kiʻina hana i mana ma ka hapa, no ka mea hana waiwai ma ia excreted ole loa.

Cautions

I ka lāʻau a me kona analogs mea i paipai no ka lōʻihi-makahiki hoʻohana. I ka hoʻomaka o ka iapaau ana koi ikaika aku ka mālamaʻana o nā keena o kaʻike ākea koko, e like me ka pono me ka mālamaʻana o ke akepaʻa nā'ūhū.

I ka wā e hiki mai, i ka kela la i keia mana o ka mai, e mālama nei i ka mālamaʻana haʻawina hookahi a palua ka mahina.

ka hopena

I ka lāʻau a me kona analogs i hoʻokohu 'ia wale nō ka hoao ana i ka hoʻomalu. Ma mua o ka lawe i ka mea pono, e undergo i ka piha keia hookolokolo ana a me ka hiki hoʻomaka ka hoʻoponopono Inc. No ka 'ike hou aku, mau hiʻohiʻona nō i ka hookohu o ka "Azathioprine" e hoomakaukau i olelo ao no ka hoʻohana. Price, analogues o keia koʻi 'ano he māhele o ka nalu o nā mea maʻi. Penei, ka palena iki ka lilo o ka 50 o na papa io o loko o ka wahi o ka 250-300 rubles, a e pili ana i analogues kau aʻela ma luna. Ma mua o ka lawe oe e ke kaumaha i ka "pros" a me ka "Con" a hoʻomaka lapaau.