Carbonic anhydrase nā mea kūpale:ʻano papa hana o ka hana o ka maka kulu no ka glaucoma

Carbonic anhydrase nā mea kūpale i diuretics, i mea ole hoʻohana i diuretics a mochegonki. PAaIEN no kēia mau ai 'o glaucoma. E mākou noʻonoʻo i nui au mamuli o ka loa Popular poʻe.

Acetazolamide (Acetazolamide)

Ua loaʻa diuretic waiwai. I pau ka moni carbonic anhydraseʻaʻa puʻuwai proximal tubules ho'ēmi i kā ka reabsorption o K, Na a me ka wai (diuresis ke kumu no ka mahuahua), e hiki aku ai i ka emi ma ka BCC a metabolic acidosis. Carbonic anhydrase depresses ka ciliary kino , a hiki aku i ka hookuu ana i ka intraocular puʻe, a me ho'ēmi i kā ka secretion o koʻana koko Quotes i loko o ka lolo a nā antiepileptic haʻawina. He mea maikai omo mai ka gastrointestinal'āpana, Cmax i loko o ke koko i loko o nā hola. Hookoia hiki hope mai i ka 12 hola. 40-60% emi IOP a ho'ēmi i kā ka? Iecaianoaaiiie o intraocular loli.

Nāʻikepili & laʻau heluna

I ka papa kuhikuhiE nāʻikepili: ocular hypertension, glaucoma. I glaucoma, i ka loko lawe ma 0.125-0.25 g. 1-3 manawa i ka lā, i kela la i 5 lā, ma hope o i nele i ka elua-lāʻoluʻolu.

ʻaoʻao 'ole: nausea, lilo o ka ikaika loa ka makemake, diarrhea, allergies, hoʻopōʻino ano o ka nano, paraesthesia, tinnitus, drowsiness. A pau i kēia hiki kāhea carbonic anhydrase nā mea kūpale. Hoomakaukau i kekahi contraindications. Kēia excessive pā lonoaʻili (i sulfonamides me), Addison ka maʻi, 'ino i ka acidosis, huʻi ake maʻi a me nā konāhua maʻi, hāpai keiki, mimikō mellitus, uremia.

'Āpana palena: pulmonary embolism, pulmonary emphysema (hiki e māhuahua acidosis).

Ke k: papa hua mai ma Poland Polpharma "Diakarb" i 0.5 g.

Dorzolamide (dorzolamide)

Inhibits carbonic anhydrase isoenzyme II Haʻawina (OOOXO reversible hydration naoh o ke kalapona'okikene lua a me ka carbonicʻakika dehydration) maka ciliary kino. ua hoemiia Secretion intraocular ona mau ma ka 50%, 'aʻole hoʻi ia i ke kahua o bicarbonate Ion, a me ka hapa' ia 'ho'ēmi i kā ka amo ana o ka wai a me ka paʻakai. Hoemi ma ka 38% o? Iecaianoaaiiuo o intraocular loli i aʻole e pili mai ka outflow. Ua komo i loko o ka'ōnohi a poʻopoʻo ka puleʻAmelika, ma ka lala, cornea paha sclera. Hapa 'ia' paka i loko o ka systemic vascular moe o ka Eye mucosal (paha e ana diuretic a me nā 'ole typical sulfonamides). Ma hope o ka waiwai i loaa i loko o ke koko, hoʻomaka koke komo i loko oʻulaʻula koko keena, i pihaʻi me nui dala o carbonic anhydrase II. Dorzolamide 33% nakinakiia i ka wai koko nā polokina. ʻO kā mākou hypotensive hopena hoike mai ai ia ma hope o instillation ma o ka 2 hola, a papa kāwiliʻai ia 12 hola. I ka backfilling no 2 manawa ma 9-21% no ka lā emi intraocular puʻe ia ka haʻaheo me 3 manawa i ka lā - i 14-24%. Ka ho'ēmiʻana o intraocular puʻe ma ka hoʻohana 'ana i ka 2% pāʻoihana hiki e i kā mākou 4,5-6,1 mm o Hg. A pāʻoihana a 3% makemake e emi mana no ka mea, e koke holoi mai o ka conjunctival lua e like me ka mea e hookomo ana ikaika kīhaeʻia. Ma ka huipūʻana a me ka manawa i oleloia ai timolol mai he hou nō i kanawai mai ka 13 a hiki i 21%. Ka palena haʻahaʻa hopena ma luna o ke koko, a me ka naau kōmi i carbonic anhydrase nā mea kūpale. Diuretics keia pūʻulu ua i hoʻohana 'ia no kona manao hana. Ma keia hope.

Nāʻikepili & laʻau heluna

Nāʻikepili: iniiaiie a me ka haumāna e hamama ana-huina glaucoma, ocular hypertension. Ka lāʻau 'Ua hōʻikeʻia 1 kulu 2-3 manawa i ka lā.

ʻaoʻao 'ole: paresthesia, ke kaupaonaʻana poino, kaumaha, ili rashes, aplasticheskayaanemiya, agranulocytosis, luhi, headache,ʻawahia epidermal necrolysis, awaawa ho'āʻoʻana i loko o ka waha, nausea, mea ulu i loko o ka mānoanoa o ka cornea, iridocyclitis, blepharitis, keratitis, conjunctivitis, photophobia, blurred hihiʻo, maneo a tingling ka waiʻona ma loko o ka maka, discomfort, Stevens - Johnson maʻi pale, kuni, lua maka.

Ke carbonic anhydrase inhibitor (maka kulu) i ka i kēia contraindications: excessive pā lonoaʻili (i sulfonamides me), kamalii, huʻi ake maʻi a me nā konāhua maʻi, hāpai keiki, a breastfeeding.

E hoomakaukau ai: eyedrops "Trusopt" i loaʻa ka 1 ml o 20 mg dorzolamide hydrochloride pāʻoihana. hue - 5 ml. Ua ua hua mai i loko o ka Netherlands ma Merck pahi & Dohme.

Carbonic anhydrase nā mea kūpale: Brinzolamide (brinzolamide)

Innovative blocker o carbonic anhydrase me ka hiki i ka wa a hoopili topically i nui ka ho'ēmiʻana a me ka hooponopono ana IOP. Brinzolamide paʻa kiʻekiʻe selectivity no carbonic anhydrase II, a me ka loa kupono physical waiwai e kuleʻa komo i loko o ka maka. I ka hoʻohālike me ka dorzolamide, a atsetozolamidom mea ike ia brinzolamide - ka loa potent waiwai pae o carbonic anhydrase nā mea kūpale. Aia ka hōʻike i topical paha intravenous mea, o ka brinzolamide hiki aku ai i ka hana ana i ka optic pā hōkū. A e ho'ēmi i kā ma ka awelika o ka 20% IOP. Ua 'Aʻole e holopono ana i ka carbonic anhydrase nā mea kūpale. Keʻano papa hana o ka hana hanana mai brinzolamide.

Nāʻikepili a me ka laʻau heluna

Nāʻikepili: ocular hypertension, e wehe ae-huina glaucoma. E hoʻohana i 2 manawa i ka lā i ke kulu.

ʻaoʻao 'ole: hoao perversion, haole kino ka waiʻona ma, blurred hihiʻo ma luna o instillation (manawa) a me ke ahi ka waiʻona ma. Hoolilo Tuamotu maikaʻi ma mua o dorzolamide.

Contraindications: excessive pā lonoaʻili i ka lāʻau (i sulfonamides me), na keiki o ka makahiki, hāpai keiki, a breastfeeding.

E hoomakaukau ai: eyedrops "Azopt" i loaʻa ka 1 ml o ka wehe 'ana o 10 mg brinzolamide. Nona iho i ehiku huewai o 5 ml. Hua mai la i ka Hawaii ma Alcon.

He aha hou aʻe i carbonic anhydrase nā mea kūpale?

prostaglandin nā mea loaʻa

Latanoprost (latanoprost) - prostaglandin mea loaʻa e wae agonist. Maoli he outflow o intraocular loli ma ka uvea, i hiki aku ai i ka hookuu ana i intraocular puʻe. Hopena ma luna o ka? Iecaianoaaiiie o koʻana koko Quotes eʻaʻole kōkua. Ke hoʻololi i ka nui o ka haumāna, akā, wale iki. I ka backfilling komo i loko o ka palapala o ka isopropyl Etera ma ka cornea, a malaila hydrolyzed i ka moku'āina o ka biologicallyʻeleuʻakika, i hiki ke ho'ākāka 'ia i loko o ka mua 4 hola ma intraocular loli, a ma ka wai koko i loko o ka hola mua. 0,16l / kg - ka leo o ka o ka makana. , Elua no hora ma hope hou loaʻa ka mea kiekie loa lehulehu i loko o ka koʻana koko Humor, ma hope i ka mea, ua haawi mai la i ka hoʻomaka o ka mua Hoʻohana, a laila na lihilihi, a me ka conjunctiva, a laila, komo i loko o ka posterior Hoʻohana (ma ka liʻiliʻi dala). Kaʻeleu palapala i loko o nā nā'aʻaʻa o ka maka ua kokoke i metabolized,ʻano nui i loko o ke akepaʻa biotransformation. Advantageously, e excreted metabolites i loko o ka mimi. E ka nana aku ma kekahi o ka carbonic anhydrase nā mea kūpale.

Unoprostone (unoprostone)

Isopropyl unoprostone mea he derivative o ka docosanoid hoʻomaka koke hoemi intraocular puʻe (IOP) ka hoʻohana 'ana i ka hope pharmacologicʻano papa hana. Me ka hoʻololi 'ana i ka manawa? Iecaianoaaiiuo o ka intraocular loli, kōkua ai i nā kona outflow. Ua hōʻike Hawaiʻi mea, like me ka 0.5% timolol maleate, isopropyl unoprostone ua 'ano like' ole a hiki maikaʻi hope e ho'ēmi i IOP. Ka lāʻau 'Aʻole i pili i ka noho a me ka malama ole i ka ho'ēmiʻana o ke koko i loko o ka ocular nā'aʻaʻa, miosis paha mydriasis; corneal e noho kali hou aku kekahi i 'akomi i. Ma hope o topical kŰlń isotropy unoprostone i ole ia akulla 'ma ka wai koko.

carbonic anhydrase nā mea kūpale no glaucoma E e hoakaka ia wale nō ma kekahi kauka, pakiko-ka lapaʻauʻia ua ole ae.