Ka lāʻau "Doxorubicin": manual, hōʻike manaʻo, kiʻi, hoʻokuʻu palapala, laʻau heluna, pūnaewele. "Doxorubicin-Lance": kauoha no ka hoʻohana

I ka maʻi 'aʻai Ua loa pilikia i kanaka ola. Ua ninoieo o malignant, a kipi proliferating keena, i ka poe hiki ke komo i loko o ka puni'aʻaʻa, a metastasize i nā nā loko.

Ka hooulu ana o ka ai 'a me ka ohe. No na maʻi mea nui i hana. Eia naʻe, hiki i keia manawa i kekahi a hiki i ka hopena, a au i i hoʻoholo. 'Oiai, he mea nō ai' e hiki 'ūlōlohi i ka mahele o kaʻeho keena. Kekahi o ia haawiia ka lapaʻauʻia "Doxorubicin". Na Ke Kumu no ka hoʻohana a me ka Hawaii photo o ka lāʻau e uhi nō i loko o kēia 'atikala. Ma ia oe, e 'imi' ike e pili ana pehea e malama aku la mea ma i kuahene ia mea loaʻa i mea kuai, a me ka oi.

'ōpala, haku mele 'ana, shape a me ka hōʻikeʻano

Ma ka palapala ua kuai "Doxorubicin"? Na Ke Kumu no ka hoʻohana hōʻike ka mea kēia 'ano o ka huahana.

• Lyophilizate no ka makaukau o ka pāʻoihana no intravascular a me ka intravesical ka pahu kui. He ka ula-yellow porous nuipa a iloko ona i kakauia na hana waiwai e like me doxorubicin hydrochloride. E like me nā nā mea hoʻohui ka hoʻohana mannitol. Ka lapaʻauʻia ua kuai lilo aku la i loko o ka hue ili, puni iho la ia ma ka pepa pahu.
• Noʻonoʻo no ka hana i kākoʻo pāʻoihana no intravascular a me ka intravesical ka pahu kui. He heʻulaʻula, a aniani moakaka wai a iloko ona i kakauia doxorubicin hydrochloride a me ka mea i loaʻa i loko o ka hue ili a me cartons.

Ke pharmacology o ka lāʻau

He aha ka keia lapaau like "Doxorubicin"? Na Ke Kumu no ka hoʻohana (hoʻokuʻu ano o ka lāʻau i hōʻike ma luna) ai ia mau moʻolelo i mea mea he Anati-ʻeho anthracycline antibiotic, i i kaʻawale mai moʻomeheu o ka fungus Streptomyces peucetius. He mea hiki ke kulia antimitotic a me ka antiproliferative 'ole.

Interacting me ka DNA, ka medicament inhibits RNA polymerase, DNA polymerase a me ka topoisomerase type 2, a me kekahi haʻalele no ka? Iecaianoaaiiie o noa radicals, a hana ma luna o ka halepaahao paia. E like me ka hopena o ia hopena ka lohi o DNA replication a liluwelo nukeleaʻakika hoʻololi kemikala.

He mea hiki ole keia i ole e hoailona oukou i ka mea i loaʻa i ka pololei cytotoxic ia mākou e noonoo pono i ka mea. Ke keena ho'āʻo i kekahi pā lonoaʻili i ka lāʻau i loko o ka G2-pae a me S-pae o ko lākou ola.

kinetic waiwai

He aha kinetic kiko'î hoʻomaopop 'ana i loko o ka lāʻau "Doxorubicin"? Na Ke Kumu no ka hoʻohana hākālia nō ia ma hope o ka pahu kui intravenous, o ka mea paahana mau haawi multiphase. Iloko o ka mea mua 5 minuke o ka medicament hoʻomaka koke hoopio'aʻaʻa, a me kona lehulehu i loko o ke koko emi hikiwawe loa. Like no ka lua o ka pae, ka mea, ua lawe mai na mea lāʻau nā lātoma mai na nā'aʻaʻa.

Noʻonoʻoʻeleu lāʻau i loko o ke ake, puupaa, spleen, maʻiʻaʻai a me myocardium. Ua i komo iloko o ke keiki, a ua excreted me ka umauma o ka waiu.

Pane i ka wai koko nā polokina ia lŘlŘ ka 75%. Pūnao o ai 'ma ke akepaʻa, ma ia ho okumu i kaʻeleu derivative e like me doxorubicinol.

Iloko o ka ka ho'ēmiʻana o noa radicals'ūhū hoʻololi kemikala mea e loli i ke kūpono 'ana o cardiac kaʻawahia.

Hapa-ola o ka doxorubicin a me ka like doxorubicinol a me ka mea e pili ana i 20-48 hola.

Kahi o 40% o ka mahele lāʻau o ka lāʻau ua hookuu pu me bile, a wale 6-11% o ka doxorubicin a me kona nā mea loaʻa, no ka mea, ua loaʻa 5 mau lā ma ka mimi.

nāʻikepili

lāʻau "Doxorubicin" hiki e kohoia i ka maʻi?

Na Ke Kumu no ka hoʻohana (no ka bladder Ka maʻi 'aʻai mea he hoʻopololeiʻia ana loa pinepine) ia hākālia nō i ka lapaau hanaʻia pono ia:

• thyroid gland Ka maʻi 'aʻai, Kaposi ka sarcoma a me Ewing;
• Wilms 'ʻeho, gastric Ka maʻi' aʻai, uuku aeea ke ano o ke akemāmā Ka maʻi 'aʻai;
• insulinoma, umauma Ka maʻi 'aʻai, mesothelioma;
• esophageal Ka maʻi 'aʻai, carcinoid, neuroblastoma;
• osteogenic sarcoma, iniiaiie hepatocellular carcinoma, ole-Hodgkin ka lymphoma ;
• Cancer o ka prostate gland, Ka maʻi 'aʻai o ke poo a me ka ai, malignant thymoma;
• cervical Ka maʻi 'aʻai, kekahi mauʻano o testicular hikoko;
• uterine sarcoma, endometrial Ka maʻi 'aʻai, Hodgkin ka maʻi;
• rhabdomyosarcoma, huʻi leukemia;
• maʻi lymphocytic leukemia, mau myeloma.

Contraindications

He aha nō i keʻano o ka hoʻomanawanui i koi 'ia e pāpā aku iā ia i ka lāʻau "Doxorubicin"? Na Ke Kumu no ka hoʻohana 'ana, maoli oncologists e olelo aku i ka mea paahana proves ole loa mana i loko:

• sensitization e doxorubicin 'ole' ē aʻe lāʻau 'ona, e like me ka pono me lunamakaainana o anthracyclines a me anthracenediones;
• mamua Inc, a me lālā 'ē aʻe o ka anthracycline anthracenediones i loko o ke kaupalenaʻana nā māhele, e like me ake hoʻokō' ole '(loa), myocardial infarction, arrhythmias, huʻi mea hoʻomaʻi nā mea palahēhē a me ka naau ka hoʻokō' ole (no ka intravenous hooponopono);
• malignant hikoko, germinating i loko o ka pā o ka bladder, urinary'āpana nā mea palahēhē a me cystitis (no ka intravesical).

Me ka lōʻihi mālama nui, keia k E e hoʻohana no ka poʻe i loaa mālama nui chemotherapy, e like me ke kamepiula kumumea no cardiotoxicity, kue o ke akepaʻa, iwi nä lolo infiltration o ka maʻi 'aʻai keena a me ka obesity.

Eia hou kekahi, pono noʻonoʻo i ka lāʻau 'ua hoakaka ia no na keiki a me na kanaka a nui kona mau makahiki, a me hapa o ka nunui-? Ueo a multicomponent antitumor Inc.

Uluwehi O "Doxorubicin": aʻo no ka hoʻohana 'ana, laʻau heluna

E like me na kuhikuhi, noʻonoʻo i ka lāʻau hiki ke lawelawe intraarterially, intravenously a intravesically. Ua E hoi e kaulana i keia mea paahana, e e hoʻohana singly a ma ka hoʻohui pū 'ia me nā cytostatic ai' i loko o kekahi dosages.

Reconstituted lāʻau pāʻoihana "Doxorubicin" mea e e hoʻohana koke ma hope o kona hana.

Intravenous ka pahu kui hoʻomanaʻo

Ma ka paipai laʻau heluna o ka monotherapy "Doxorubicin" no kalapona mea 60-75 mg / sq. m kela ekolu pule. Nō kāu, i ka lāʻau ua injected kekahi manawa. Naʻe, i kēia mahele lāʻau i e lawelawe, a no ka mau injections (i loko o ka nui o 25-30 mg / sq. M no lā no ka mea mua 3 lā o ka pōʻaiapuni).

E emi i kaʻawahia hopena o ka hana i hoʻohana pule aaieieno? O 10-20 mg / sq. ka m manawa o ka pule.

I ka hui a me nā anticancer Lunaʻeleu medicament ua lawelawe i loko o ka laʻau heluna kalapona i loko o ka nui o 30-60 mg / sq. m kela 4 pule.

Hai nā papa o ka lapaʻau lawe mai ma hope o ka hoʻopau o nā symptoms o kaʻawahia wale.

Ka huina mahele lāʻau o ka lāʻau e ole e oi aku mamua o 550 mg / sq. m.

Ke kūʻai '-arterial hooko ana o ka Agena

Pehea o ke kūʻai '-arterial ka pahu kui "Doxorubicin" ia waiʻona? Kuhikuhi Hawaii i ka i sidetone kanaka me hepatocellular carcinomaʻeleu medicament e e lawelawe ai i ka pono hepatic artery i loko o ka laʻau heluna o 35-150 mg / sq. m. I ka Ia manawaʻanuʻu ma waena o ka pōʻaiapuni e e like mai 3 pule i 3 mahina.

I ka hoike ana o ka lāʻau i loko o ka bladder

E like me ka bladder injected lāʻau "Doxorubicin-Teva"? Na Ke Kumu no ka hoʻohana mau moʻolelo i keia laʻau heluna o ia hoʻi, no ka intravesical aaieieno? E e 35-50 mg no mea hoʻonoho.

Lapaʻau o ke kaʻina hana pono e lawe mai maʻanuʻu o 7-28 lā, ke kaumaha ma muli o ka mea (Kāohi 'ole lapaʻau).

Lehulehu o ka lāʻau pāʻoihana e e 1 mg / 1 ml wai pāʻoihana a me physical.

Instillation ua hana i loko o 2 hola. I ka pau ana o ka hoʻomanawanui e ninini i ka bladder.

ʻaoʻao waiwai

E hoomakaukau ai "Doxorubicin", a ke ao i ho'ākāka 'ia ma luna i i ke kēiaʻaoʻao reactions:

• ka luaʻi, abdominalʻeha, nausea, colitis, stomatitis, diarrhea, esophagitis, ku una mucosa hyperpigmentation, anorexia, mahuahua bilirubin lehulehu i loko o ke koko, gastrointestinal kahe ana ke koko, a mahuahua nui hepatic transaminases;
• mahele lāʻau-e kaukaʻi reversible leukopenia, thrombocytopenia, anaemia, leukopenia, neutropenia;
• sinus tachycardia, atrioventricular aeie, tachyarrhythmia palapala congestive naau e hemahema, bradycardia, thrombophlebitis, kona laulau lala aeie, abnormalities ma ECG, ventricular arrythmia, pulmonary embolism, phlebitis, thromboembolic complications;
• amenorrhea, oligospermia, hyperuricemia, urinary ula i hookohu aku i, azoospermia;
• conjunctivitis, keratitis, lacrimation;
• ʻike ākea neurotoxicity, ke kāʻili 'ana, coma;
• edema, reversible alopecia, photosensitivity, ili hyperpigmentation, lapuwale ia, ka ohane, ua hanahana loa ka eha, poʻe noʻonoʻoʻole, erythema, nā hua epidermis;
• dermatitis, poʻe noʻonoʻoʻole, bronchospasm, ili flushing, anaphylaxis;
• Local phlebitis, ia li nui, fleboskleroz, thrombophlebitis, kūlokoʻeha,'aʻaʻa necrosis;
• polyuria, nocturia, dysuria, necrosis o ka bladder membranes, hematuria, discomfort, ola urination;
• erythematous striation ma ka ka pahu kui paena;
• luhi, malaise, kuni, ole, ka ulu ana o ka lymphocytic ole myelocytic leukemia (huʻi), hyperuricemia, iʻa, nephropathy;
• ulcer 12 duodenal / gastric, biliary sclerosis.

symptoms o overdose

He aha nō nā'ōuli o ka overdose i hoʻomaka ai ka wā e hoʻohana i ka nui helu o "Doxorubicin" ia waiʻona? Na Ke Kumu no ka ho ohana i Hawaii i ka overdose o na dala ke alakai i kaʻawahia symptoms i hoikeia aku ai e ka digestive'ōnaehana, e like me ka loa myelosuppression. Eia hou kekahi, kiekie nā māhele o ka lāʻau hiki e kokoke oluolu i ka i huʻi naʻau maʻi.

An antidote i ka lāʻau "Doxorubicin" hakuʻole. I overdose hoʻohuli ai i nā lawelawe symptomatic Inc. No hoi, ka mea, ua hospitalized, a ua malamaia lakou nei, me ka antibacterial ai '.

lāʻau hana kūleʻa

Ua mea hiki, e hui pu iho la me nā lāʻau ai ' "Doxorubicin"? Na Ke Kumu no ka hoʻohana hōʻike i ka wā e hoʻohana i kēia koʻi i loko o ka hui pu ana me nā cytotoxic ai 'pinepine höÿike kā lākou mea hoʻonui kaʻawahia.

A i kekahi hui malu pu ana lāʻau a me nā cytotoxic ai ', a i cardiotoxicity (e like, "FU" a me "Cyclophosphamide"), pono akahele ka mālamaʻana o ka naau iloko o ka papa holoʻokoʻa o Inc.

"Streptozocin" maoli i ka hapa-ola "Doxorubicin".

Ka Inc "Doxorubicin" ka hoʻomanawanui e hoike aku lakou i na hoailona o ka huʻi hemorrhagic cystitis ma hope o lapaʻau "cyclophosphamide", e like meʻoi loa maila i ka kŰia o ke akepaʻa kaʻawahia ma hope o kanaka "mercaptopurine."

Ka hoʻohana o "Paclitaxel" ma mua o ka maoli hoike o "Doxorubicin" e hoʻonāukiuki ka ulu i loko o ke koko lehulehu o ka hope.

He aha ai 'i pāpā mai ka hoʻohana lāʻau' "Doxorubicin"? Na Ke Kumu no ka hoʻohana (no ka holoholona ia,ʻaʻole ia) ai ia mau moʻolelo i e ole keia mea paahana e hui me ka 'ē aʻe ai'. No ka laʻana, ka mea, mea hana lāʻau hana maʻalahi me ka "heparin", "Dexamethasone", paʻakai succinate, "hydrocortisone", "cephalothin", "aminophylline", "FU" a me nā anticancer ai '.

I ka hui me ka ola mea hoʻomaʻi vaccines mea hiki ia mea hoʻomaʻi replication, a mahuahuaʻaoʻao reactions a emi lāʻau lapaʻau kino hoʻololi kemikala i loko o ka hoomanawanui ka kino ma muli o ka pono o ka vaccines.

I Kekahi Mau koi ma o ka hoʻohana 'ana o ka ai'

He aha oe e ike mua ka hoʻohana 'ana i ka "Doxorubicin-Lance"? Na Ke Kumu no ka hoʻohana i ka 'ia i loko o ka papa o ka iapaau ana antineoplastic Luna e pono ai, e lawe mai ka pololei, ka mālamaʻana o ke akepaa hana, i ke kiʻi o kaʻike ākea koko, ECG a me ultrasound o ka naau.

kuai na kumu, ano o ka pūnaewele a me ka holopapa-ola

Where e ka lāʻau "Doxorubicin-Lance"? Na Ke Kumu no ka hoʻohana mau moʻolelo e pono e mālama i kēia koʻi i loko o ka'āina maloʻo a me ka pouli wahi kahi i ka mahana, aole ia i oi aku mamua o elima degere.

Ke medicament Ua hookuu i keʻena kūʻai lāʻau lapaʻau e kuhikuhi wale. Kona holopapa ola he mau makahiki.

Price a me analogues

Ke kumu o ka lāʻau ua noʻonoʻo 120-150 rubles i loko o 5 ml. Inā e pono ai ka mea, hiki auou caiaiai ia e na mea i "Doxorubicin-Teva", "Lachema Doxorubicin", "Onkodoks 50", "10 Onkodoks", "Doxorubicin-Ebewe", "CRC-Doxorubicin" a me na mea e ae.

Consumer hōʻike manaʻo o ka lapaʻauʻia

Ano, e ike ana i ka hoʻohana 'ana i ka lāʻau "Doxorubicin". Na Ke Kumu no ka hoʻohana a me ka pūnaewele o ka lāʻau i hōʻike mai iā ia ma luna.

Muli o kona kulana he nui helu o ka consumer hōʻike manaʻo pili me ka mea adverse reactions e hana ana i lapaau a me ka lāʻau. I kēia mau waiwai i na hui, komo, lōʻihi-ka loihi e manao ana he mai, lauoho poho a me ke kahua o ulcers ma ka ka pahu kui ioauoa.

Ma ka maikaʻi memo ka mea, i loa pohihihi keia. A me keia mea e kahaha ko oukou naau, mai ka laulā o ka anticancer lāʻau e loiloi i wale ka hoao ana i ka hoʻomalu, ma muli o ka helu nui o okoa aʻe: i ke 'ano o ka monotherapy a me ka hui pu Inc, he maʻi' aʻai, i ke ahonui o ka ana, a me ka lōʻihi-manawa i nā hualoaʻa.