Ka lāʻau "Leykostim": aʻo no ka hoʻohana 'ana, maoli counterparts

He aha mea i ka lāʻau "Leykostim"? Na Ke Kumu, hookuu palapala, nāʻikepili a me contraindications a hiki i keia k, e e ho'ākāka 'ia ma lalo nei. E hai mai no hoi oe e pili ana i ka analogs i loaʻa no keia mea paahana ua komo i loko o kona haku mele 'ana, a no laila, ma luna o.

Ke kinona,'ōpala, hapa o ka lāʻau

He aha palapala i ka lāʻau "Leykostim"? Na Ke Kumu no ka hoʻohana mau moʻolelo iʻeleu medicament ua ua hanaʻia me ke kākoʻo pāʻoihana no subcutaneous a intravenous hooponopono.

Kaʻeleu ke keʻena o ka Agena mea filgrastim. He He recombinant granulocyte panalaau ia-noho haumāna kahi ololi. 1 ml o ka lāʻau pāʻoihana e komo 300 mg (30 miliona. Iu), 600 mg (60 miliona. Iu) ole 150 micrograms (15 miliona. I.U.) filgrastim.

Like no na excipients, laila lākou hoʻohana like mannitol, paʻakai'ākeka trihydrate, dextran, aceticʻakika, polysorbate, a me ka wai no ka pahu kui.

Ma ka'ōpala pāʻoihana ua kuai "Leykostim"? Na Ke Kumu no ka hana i loko iho i loko o ka pepa pahu pū me hoʻokahi aʻelima hue o ka lāʻau.

Nā waiwai o ka lāʻau

He aha ka keʻano papa hana o ka hana o ka lāʻau i loko o "Leykostim"? Na Ke Kumu no ka hoʻohana 'ana, kauka hōʻike manaʻo aku nei au ia ia mea he lāʻau-immunomodulator. He He lahui maloko ole-glycosylated kumuʻiʻo e loaʻa he hoʻokonukonu keiki ma luna o ka ulu ana, a me ka neʻeʻana (mai ka iwi lolo i loko o ke koko) iaea ooieoeiiaeuiiai neutrophils.

i ka hoike o ka lāʻau ma hope me ka nui loa maoli ka helu ana o neutrophils i loko o ke koko a me ka wale iki - monocytes. Keia ia lŘlŘ i loko o 24 hola.

Ka mahuahua ana ma ke koko neutrophils mea mahele lāʻau-e kaukaʻi. Hanauna o biologicallyʻeleu kumuʻiʻo, a laila filgrastim, a normalizes ka ka hoʻonuiʻana a me ka differentiation o aeee lawe ma ke kanana nei o ka koʻohune Escherichia coli. Incidentally, i ka la mahope, ma muli o ia i ka uea 'o ke kālā no ka hana' enekinia aaiaoe, complemented ma'ōewe granulocyte panalaau ia haumāna kahi kanaka ololi.

E like me kona rula o ka waiwai ma ke kino i ka lāʻau mea i 'ano like me ka granulocyte panalaau ia-noho haumāna kahi ololi, i mea no maoli kumu. Ka oko ao wale nō nā kūʻiʻo i "Leykostim" (pāʻoihana) ua ole glycosylated, a ua N-maʻi'aminoʻakika koena o ka methionine.

Hiʻona o ka lāʻau

He aha nā hiʻona i ka lapaau "Leykostim"? Na Ke Kumu no ka ho ohana i hākālia nō i ka mea e e ia i loko o kaʻike, o ka neutropenia i loko o kanaka, ka poe undergo chemotherapy. Nō hoʻi, i kēia k ka loa mana no ka maʻi neutropenia. Keia mea aie a hiki i ka nui, e hoike ana ia mea hiki ke hoihoi i ka pau e pono ai ka helu ana o neutrophils i loko o ke kanaka kino.

E ho ohana i ka hoʻomanaʻo no ka Kāohiʻana, i ka hoʻomanawanui hiki me ka nui loa emi i ka mea hiki wale mai o neutropenia, e like me emi i ka ka manaʻo pohihihi o ka pele, a me ka lōʻihi like wā o ka maʻi. Oia waiū ua ālai 'infectious complications, hoemiia ahonui lōʻihi o ka haukapila noho ana, e leie aku chemotherapy me ka haalele ana mai o nā hua'ōlelo i i ua hoʻokumu mau noaia o ka lapaau.

E like me ka kanaka kino hana "Leykostim"? Na Ke Kumu no ka hoʻohana i ka 'ia ka hoʻohana' ana i ka lāʻau 'ka poʻea pau i ka olelo ma kaʻike ākea koko keena mamua hematopoiesis, a i ohi ia ma ka cytapheresis (a laila, e hoʻokēʻai i ke koko i loko o ke kelepona hele ke keʻena me ka mea e wae wehe' ia) a me ka lawelawe ana i ka hoomanawanui ma hope o ka papa o ke kiʻekiʻe-mahele lāʻau chemotherapy.

I huli ai oe, o ka injected aeee (kumu) ka hematopoietic hana, hoemiia'ōnaehana paleʻea a me ka hematopoietic'ōnaehana, e like me emi i ka pilikia a me ka oolea o infectious a me ka hemorrhagic complications.

ka lapaʻauʻia maluhia

He maluhia no kanaka lāʻau "Leykostim"? Manual Hawaii i keia k hiki ke hoʻohana 'ia no nā keiki a me nā mākua. He like maluhia no nā kanaka e loaa ana cytotoxic chemotherapy.

Nā mea maʻi me ka immunodeficiency mea hoʻomaʻi noi pāʻoihana hoʻolako i ka kaʻoi loa kiʻekiʻe o neutrophils, a haawi i ka manawa kūpono e hahai i ka paipai dosages o antiretroviral a myelosuppressive Inc.

I ka hoʻohana 'ana i kēia huahana o HIV replication i malama.

Pharmacokinetics

He aha pharmacokinetic lāʻau i "Leykostim"? Instruction Hōʻike i ka lehulehu o ka hana 'Oponopono o keia Agena mea pololei e kaukaʻi ma ka lawelawe mahele lāʻau.

Ma hope o subcutaneous hooponopono, i ka huina nui o ka lāʻau i loko o ke koko malama ma hope o ka hola 8-15 hola.

Ka hapa-ola "Leykostima"ʻeleu mea mea ekolu i eha hora. Filgrastim metabolized i peptides. About 1% o ka hana ke keʻena 'ōili mai ua hoʻololiʻia i loko o ka mimi.

Filgrastim hoʻomāhuahua i loko o ke kanaka kino, aole ia i hoʻomaka ai, a hiki ma hope o hooloihi ae i hoʻohana ana i ka lāʻau '(ka wā o ka Inc aku i mahina). Ma kēia wā o kona hapa-ke ola o ka ia.

nāʻikepili

"Leykostim" ka laau lapaau ua hoakaka no ka mea kēia mau hana:

• no ka hoemi i ka lōʻihi like 'ole o ka neutropenia pele u 2-4, a hoi e emi i ka mea hiki wale mai o febrile neutropenia i kānaka me ka hikoko nemieloproliferativnymi ma hope o chemotherapy me cytostatic konohiki;
• e emi hoike ana mai o complications i ala mai ka wā neutropenia, e like me ka hoemi i ka papa manawa o ka maʻi i loko o kānaka undergoing myeloablative chemotherapy me ka iwi lolo transplantation mea;
• aeea Maui māhele ma mua o hematopoiesis i loko o kaʻike ākea koko no ka mea o ka hookaawale ana a me ka transplanting ia ma hope o myelosuppressive chemotherapy;
• no ka iapaau ana o ka neutropenia i loko o kanaka me HIV maʻiʻaʻai (a me ka poʻe i loko o ka holomua ke kahua) i mea e emi i ka pilikia o infectious maʻi o ka mea koʻohune me Kinohi;
• no ka iapaau ana o ka maʻi neutropenia;
• aeea? eou mamua hematopoiesis, i loko o kaʻike ākea koko o ola nā mea hāʻawi no e transplanted a hookaawale maʻi ia.

Contraindications

He aha e na contraindications lāʻau i "Leykostim"? Reviews 'Oihana hai mai i ka i kēia manaʻo pāpā o:

• hoonuiia kanaka pā lonoaʻili o ka hoʻomanawanui i ka hana a me ka 'ē aʻe nā mea hoʻohui i loko o ka haku mele' ana o ka lāʻau;
• congenital neutropenia, loa e kahe ana i loko me ka cytogenetic kāna hana (Kostmann maʻi pale);
• neonatal manawa (ka oi aku i ka malama mua o ke ola).

Uluwehi O "Leykostim": ke aʻo a me ka palapala noi

Nānā akula au i ka lapaʻauʻia hiki e lawelawe i loko o nāʻaoʻao:

• intravenously;
• subcutaneously.

Laʻau heluna a me ka hana o ka aaieieno? "Leykostima" E e hooponoponoia ia mea, ma ka poe akamai, ke kaumaha ma muli o ka lapaʻau kulana, na ano kanaka o ke ahonui, a me ka maʻi. Naʻe, ka mea e e hoʻomaopopo i ka 'inikua hana ka mea, ua makemake ko subcutaneous hooponopono o ka lāʻau.

No ka intravenousʻeleu medicament ua haalele mai i ka hue ma ka 'ohe, a laila ka mea i hou ia i ka hue o ka 5% dextrose. Ke kūpono pāʻoihana ua lawelawe i ka hoomanawanui no ka hapalua o ka hora.

Pehea e pili "Leykostim"? Na Ke Kumu (analogues o keia lapaau, e e kūkā mai ma lalo nei) hākālia nō i ka lāʻau e e hoʻohana i mua ma mua o ka lā ma hope o ka pauʻana o ka chemotherapy.

Ka lāʻau pāʻoihana Ua lawelawe iho la no ke kaumaha ma muli o ka hoʻomanawanui ka hoʻokauʻana. Ka mahele lāʻau papa koa o 5-12 mg no 1 kg kaupaona. ua mālamaʻia Injections lā kēlā me ke alapine (frequency) o ka manawa hookahi i ka lā.

Inc ua noʻonoʻo pono i ka lāʻau e halihaliia oia iwaho like loa me ka helu ana o neutrophils i loko o ke koko mai i hiki mahana maʻamau. Nō kāu, i ka iapaau ana Duration He mau pule.

Ma aaieieno? E koi hoʻomalu e mau ho oholo i ka helu ana o leukocytes i loko o ke koko. Inā ka helu, ua oi aku ma mua o 50.000 / microliter, i ka lāʻau kahuli.

Ma Inc, i ka hoʻomanawanui i hoʻomōhala thrombocytopenia. Ma ka hihia i loko o hai assays ka platelet helu waiwai ua mālama lalo 100.000 / microliter, laila huli ka pokole ke kāpaeʻana o ka lāʻau a me ka hoemi kona laʻau heluna.

ʻaoʻao waiwai

E like me ka 'ikepili helu, ka lāʻau "Leykostim" kākaʻikahi ke kumu adverse reactions. Naʻe, ka mea hiki nō he hoʻonui i ka muli o ua mau loa, e like me:

• dysuria;
• ʻeha ma nā iwi a me nāʻiʻo;
• alopecia;
• hepatomegaly, splenomegaly;
• hypotension (transient);
• hoonuiia pae o uricʻakika a'ākilikai phosphatase;
• nawaliwali, headaches a me ka luhi;
• allergic reactions ma ka hoʻomaka o ka iapaau ana, a pinepine i hoʻomaka ai ma hope o intravenous hooponopono ana o ka lāʻau.

It E e kaulana no hoi i ka wa a ka pololei ole ka pahu kui e hoopilikia i ka hoʻomanawanui discomfort ma ka ka pahu kui paena.

lāʻau hana kūleʻa

Ma mua o ka hoʻohana 'ana i kēia k, oe pono e pohihihi mai pehea e pāʻani aku me nā lapaau "Leykostim". Na Ke Kumu (Inn o ka lapaʻauʻia kani e like "filgrastim") kekahi i ka piha 'ike ma:

• Medicament "5-FU" Hoʻoikaika i ka neutropenia.
• No ka mea, e ulu ana myeloid aeee i loa ikepili koʻikoʻi i cytotoxic konohiki, e hoonoho i "Leykostim" E ia i ka lā ma mua ma hope o ka hoʻohana ana o kēia mau ai 'paha.
• Nānā akula au i medicament incompatible me ka paʻakai koloriside.
• I ka hoʻohana 'ana i ke kākoʻo pāʻoihana a hiki i ka olelo o ka hiki keena kēia chemotherapy E e noʻonoʻo i ka ka hoʻokōʻana emi ka wā ka hana mobilization noi "carmustine" "Melphalan" a me ka "carboplatin".

kekahi koi

Ua UaʻAʻole pono e hāʻawi aku "Leykostim" kanaka me ka hihia ake hana a me nā konāhua, me filgrastim palekana a me ka hopenaʻoi loa i loko o kēia nā mea maʻi i ole, ua? Anoee.

Nā mea maʻi me ka osteoporosis a me nā iwi maʻi, ka mea i hoʻohana i ka lāʻau noke no i na malama eono, oe e alakai i ka hooponopono ana o ka iwi nuʻa.

I ka laulā o ka lāʻau i loko o kanaka me ka uuku nui o myeloid a hiki aeee i ole, ua? Anoee. Eia naʻe, poe akamai i hoʻopaʻapaʻa ana i loko o ia mau hoʻomanawanui iki mai i ka degere o ka mea ulu i loko o ka helu ana o neutrophils hiki e me ka nui loa lalo.

Hopenaʻoi loa a me ka maluhia o ka "Leykostima" i loko o kanaka me ka maʻi myeloid leukemia a myelodysplastic maʻi pale i ole, ua hoʻokūpaʻa. Ma keia e pili ana, i ka mea maʻi ua i hōʻike 'ia.

Monotherapy noonoo ole lāʻau 'ano ua ālai' anaemia, a thrombocytopenia, a i ke kumu ma ka myelosuppressive chemotherapy. Ua Ua koi 'ia e ho oholo i ka helu ana o platelets a me hematocrit. E e kū'ē'ē ana mau mālama nui ia ka hoʻohana 'ana i ka hookahi-ke keʻena' ole he huihui 'chemotherapeutic regimens, ua ike no kā lākou hana e i loa thrombocytopenia.

Mamua o hoʻomaka lapaʻau, "Leykostimom" e pono ia e ka piha Ka Ikepili o ke koko a me ka kekahi nui o ka platelet a me ka leukocyte helu, a e makaikai i ka karyotype a me ka iwi lolo kiʻi.

I ka wā o ka iapaau ana ua koi 'ia i mau kanaka hoʻoponopono i ka mimi, a me ka nui o ka spleen.

Uluwehi O "Leykostim": analogs a me ka uku

Analogues ai 'i manaoia na kēia mau ai': "Filergim", "Grasalva", "Granogen", "Neupogen," "leucite", "Neypomaks", "Mielastra", "Neyrostim".

Like no ka uku, alaila, "Leykostima" ka loa kiʻekiʻe. Buy keia k ma keʻena kūʻai lāʻau lapaʻau ma Moscow a me nā Lūkini kulanakauhale hiki e ana o 2500-4500 rubles. Ke kumukuai o keia ka lapaʻauʻia hilinaʻi nui ma ka nui a me ka helu o nā ampoules no pack.

ka lapaʻauʻia Reviews

Eia naʻe, hōʻike manaʻo o nā mea maʻi i lawe i kēia k, mea uuku. E like me ka mea i loaʻa nō, na ka lapaʻauʻia loa pinepine hoakaka no ka'ōnaehana paleʻea'ōnaehana, e like me cyclic neutropenia i loko o nā keiki. Ke kanawai o ka lāʻau i loko o ia mau maʻi nui ka pōkole.

Ua E hoi e kaulana i loaʻa i ahonui e hoike i ka lapaʻau 'ana o "Leykostima" i loko o nā keiki a me nā mākua me ka neutropenia pili me ka maʻi' aʻai chemotherapy. E hoomakaukau ai ia keiki i loko o ka laʻau heluna o 5 mg / kg no ka lā, aole i pono tolerated.

Kekahi e hoomanawanui i hoihoi i loko o ka ninau e pili ana i ka 'ano o ka pāʻoihana mea maikaʻi: "Leykostim" a me "Neupogen". E like me ka hopena o ka lapaʻau e hookolokolo ai i i lawe mai, e kuhikuhi i ke tolerability a me ka hopenaʻoi loa o kēia mau Luna, me ka i kēia hopena a i hiki aku: lā palena pau no ka iaea o neutropenia ma hope o ka hoʻohana 'ana i ka laau i oleloia i ole kilakila. Eia hoʻi, ka mea i like na like nā hoailona o ka hopenaʻoi loa a me ka tolerability.