Ka lāʻau "valparin": aʻo no ka hoʻohana 'ana, haku mele' ana, synonyms, hoʻokoe. Reviews o ka la hoomalolo

No ke aha la au e pono ai ka lapaʻauʻia "valparin"? mea i ho'ākāka 'ia aʻo no ka hoʻohana, synonyms a me nāʻikepili o kēia k i loko o kēia' atikala.

Ke kinona a me ka haku mele 'ana o ka

He aha palapala ka hoʻomaopop 'ana i loko o ka lāʻau "valparin"? Papa - ka mea, ua i loko o kēiaʻano o ka lāʻau ma ka nīnau hiki ke kuai ma ka hale kūʻai lāʻau lapaʻau. Ka mea, ho'āʻo i ka hooloihi ae i hana, he poepoe biconvex ÿano, a me he keʻokeʻo waihoʻoluʻu ka penaʻana.

I ka hapa o ka lāʻau "valparin"? Alakaʻi eaaaony i ka hoʻopololei he valproicʻakika a me ka paʻakai valproate. Ua hoi nā ke kēia excipients: glycerol, colloidal silikone'okikene lua, evdragit E-100, hydroxypropylmethylcellulose, polyethylene glycol 1500, ethylcellulose, paʻakai saccharin, silikone'okikene lua hydrate, evdragit NOT-30D, titanium'okikene lua a me ka talc.

Buy papa hiki ke wehe i loko o ka wehe 'ana i 10 na apana i loko o ka pepa laulau niioaaonoaaiii.

ka ai '

Pehea ke ano o ka lāʻau "valparin"? Na Ke Kumu no ka hoʻohana (haku mele 'ana' o ia hoʻi, ua ho'ākāka 'ia ma luna aʻe) hākālia nō i ia mea he anticonvulsant lāʻau. Ua loaʻa ka paʻakai valproate maʻiʻo o ka 'ō me Gaba ma o ka lolo, i ka poʻea pau i kona mea ulu i loko o postsynaptic neurons.

Mākou E hoi e hoailona oukou i ka ke keʻena ma ka nīnau ololi o ka amo ana o potasiuma Ion ma neuronal membranes. Kēia kaʻina suppresses ke ana a me ka laha ana o epileptic excitation i loko o nā aʻalolo olona.

Ua E e olelo mai hoi i ka paʻakai valproate mai he anticonvulsant hopena ma acee? Iuo oeiia o epilepsy.

Uluwehi O "valparin" 'aʻole i komo i ke kiaha dala a me ka hypnotic' ole, a me ka mea,ʻaʻole e kaumaha ana i ka piko o ka hanu. Eia hou, konaʻeleu 'Oponopono aole adverse' ole ma luna o ka naʻau ana, kino ana wela o ka hoomanawanui, me kona koko, a me nā konāhua kuleana pili i.

Ke kinetic waiwai o ka lāʻau

He aha nō ka pharmacokinetic ano o ka lāʻau i "valparin"? Alakaʻi kuleana ia ma hope o kona lawe ana i ka huaale i loko o ka lāʻau hookuu o kaʻeleu waiwai hoʻomaka koke, a ma hope o 2-8 hola, hiki i ka i kā mākou wai koko ke kiʻekiʻe.

Bioavailability mea, noonoo iho la 100%.

Ka pākōlea hopena o ka lāʻau 'ōili mai a hiki i ka valproicʻakika lehulehu i loko o ke koko, e like me 45-100 mg / H wale nō ma hope. It E e mahalo i ka mea pākōlea, a pharmacological hana o na mea o ka hoi malalo o kalaʻana aku kāna mau 'ōlelo ke keʻena' aʻole e mau hilinaʻi ma luna o ka wai koko nā hoʻohui like.

Palapala manaoia lāʻau i ka wai koko nā polokina mea o ka hola 85-90%. Ua Ua metabolized i loko o ke ake, a mea auaiaea pu me ka mimi. Ma keia mua-alahele pūnao ua malamaia.

Hapa-ola o ka Agena mea e pili ana 9-20 hola. Ma na keiki, i kēia wā ua hoemiia.

Nāʻikepili no ke komo

Ma lalo o na hana hea ka loa ka hoʻokō lāʻau hoi "valparin"? Na Ke Kumu no ka hoʻohana 'ana, maoli inā pilikia ka haumāna' Oihana hoike i olelo mai ua hua mai la manaʻoi medicament no ka iapaau ana o generalized epilepsy, me ka hahai ana i ke ano o ka ho'āhewa wale:

• myoclonic;
• wa e kaawale aku;
• atonic;
• tonic-clonic.

Nō hoʻi, i kēia k ua hoakaka ia no ka hapa epilepsy, a me ka nui ua hōʻike hewa, ma:

• kiʻekiʻe generalized kāʻili 'ana;
• hui a me na mea kāʻili 'ana.

Eia hou kekahi, papa pinepine nānā akula au i hoʻohana ka wā i manaʻo syndromes (Lennox-Gastaut maʻi pale, West).

Bans ka hoʻohana o ka papa

Ua i kekahi contraindications lāʻau "valparin"? E like me na kuhikuhi mai ke koʻi lipi, he nui na kapu i ka hoʻohana 'ana o ka:

• i hāpai keiki;
• loa kāna hana i loko o ka pancreas;
• thrombocytopenia;
• hepatitis huʻi paha maʻi;
• porphyria;
• ʻeleu hepatitis hihia (lāʻau Kin);
• breastfeeding;
• makahiki o ke keiki i ka makahiki ekolu;
• hypersensitivity i ka lāʻau, a me ke valproicʻakika.

Anticonvulsant "valparin": kauoha no ka hoʻohana

Ua koho pākahi ke laʻau heluna o ka lāʻau, ke kaumaha ma muli kino paona a me ka makahiki o ka hoʻomanawanui.

Nō kāu, no ka makua ho mahele lāʻau mea 600 mg o ka lāʻau no ka lā. Ma ka hope o keia helu, a mahuahua nui e 200 mg (kela ekolu lā, e kū ai i ka makemake hopena).

Multiplicity loaa o ia hoʻi, ma lalo o noonoo mea 1-2 manawa no ka lā. Ke i kā mākou paipai laʻau heluna mea 1-2 g. O ka lāʻau no ka lā.

Papa "valparin", olelo ao no ka hoʻohana a i manaoia ma keia pepa, e e ale me he holookoa, inu he uuku nui o mehana ka wai.

I ka poʻeʻelemākule e ka dosing regimen o keia mea kökua ka mea i 'ano like me ka dosing regimen i kanaka makua hoʻomanawanuiʻana, akā, koho' ia ma luna o kekahi kanaka manawa.

No keiki he 20 kg loiloi mua mahele lāʻau o ka medicament mea 400mg no ka lā. He pono ke hoʻonui i ka huina ke kiʻekiʻe, e kū ai i ka makemake hopena (ma kahi o 20-30 mg / kg no ka lā, i loko o nā māhele 1-2).

Child he pāʻumi mai i 20 kg E hoʻomana aku anticonvulsant ka lapaʻau 'ia kēia.

Hana ma-ke ano

He aha nō kaʻaoʻao waiwai ke kumu "valparin" papa? Na Ke Kumu no ka hoʻohana notifies i kaʻai ana o keia k i loko o kanaka hoʻomanawanui iki mai i ka mahina undesirable ole:

• Allergic reactions: Stevens-Johnson maʻi pale, ili poʻe noʻonoʻoʻole, erythema multiforme, pruritus,ʻili, photosensitivity.
• Digestive'ōnaehana: nausea, hepatitis, ka luaʻi, constipation, diarrhea, pancreatitis.
• Reproductive'ōnaehana: amenorrhea kiʻekiʻe, ole menstruation.
• CNS: coma, tremors, ataxia, hoʻopōʻino ike paka i.
• hemopoietic'ōnaehana: anaemia, platelet aggregation inhibition, thrombocytopenia, leukopenia, neutropenia, ua hoʻemi fibrinogen.
• Other: ke kaupaona waiwai, lauoho poho, lāʻau lapaʻau creatinine, hyperammonemia.

Overdose anticonvulsant

ka wā e lawe kiʻekiʻe nā māhele o ka lāʻau "valparin" He aha symptoms ke kānāwai? Na Ke Kumu no ka hoʻohana (papa hiki ke kuai ma kekahi hale kūʻai lāʻau lapaʻau ma kuhikuhi) hoʻopaʻapaʻa ia i ka la ana i deliberate a accidental overdose o ka lāʻau ma lalo o noonoo i hōʻike kākaʻikahi. E like me ka rula, i ke kue o ka dosing o ka lāʻau ka poʻea pau ma ka nānā o nausea, pōniuniu, ka luaʻi, diarrhea, naehana hanu kaumaha, coma, a me ka hyporeflexia.

E hoʻopau i na rula o ka hoʻomanawanui ua kuhikuhi gastric lavage, a ho'ā 'charcoal. Inā pono, i ka hoʻomanawanui lapaʻau ua lawe mai i loko o ka palapala o ka symptomatic Inc a me ka hemodialysis.

AaOIeIOUIeXAOAaIN me nā ai '

Ina paha e komo i loko o AaOIeIOUIeXAOAaIN me nā ai 'lapaau "valparin"? Na Ke Kumu no ka hoʻohana hoʻomaopopo 'o ia i ka hoʻomanawanui i ka paʻakai valproate e listen i ke kanawai o antipsychotics, antidepressants a me antiepileptic ai'.

Haʻalele nā anticonvulsants , i manao ole lāʻau paipai 'ia ka hepatic'ūhū hoʻokomo, a no laila ka mea, aole e emi i ka laulā o ke ku una ha contraceptives.

Ma ia laua? Eaia o "warfarin" a me ka paʻakai valproate ua hoʻemi ka pakeneka o ka paa i ka wai koko nā polokina mua.

Kaʻeleu lāʻau waiwai ua manaoia hiki ke hoʻololi wai koko nā hoʻohui like o ka lamotrigine, a me ka phenytoin. I ka mea, ua hui ia me na nā mea loaʻa o acetylsalicylicʻakika anticoagulant a me ka antiplatelet hopena ua hoʻokāʻoi '.

Me ka i ka wā hoʻokahi ana "valparin" mai ethanol a me ka 'ē ai' mea e kaumaha ana CNS Hoopaa iho la (e laʻa me, Mao nā mea kūpale o ka tricyclic antidepressants, antipsychotic ai ') e hoʻokāʻoi CNS kaumaha.

Alcohol a me nā hepatotoxic ai 'hoomahuahua i ka pilikia o ke akepaʻa ka pōʻino.

Nānā akula au i hoʻomanaʻo maoli i ka hapa-ola "lamotrigine" a 'aʻole hoʻi ia kona pūnao a suppresses hepatic nā'ūhū. hiki e mahuahua ma ka pili ana me keia hapalua-ola o ka lāʻau i ka 70 hola i kanaka makua nā mea maʻi, a i ka 45 hola - na keiki.

"Valparin" mea hiki ke emi i kaʻae "zidovudine" ma kahi o 40%. A, kona hapa-ola 'aʻole e hoʻololi' ana i.

Mao nā mea kūpale antidepressants, tricyclic a me antipsychotic ai '(neuroleptics), e like me nā ai' ia ma lalo kāʻili 'ana i paepae, nunui emi i ka laulā o ka noʻonoʻo medicament.

Breastfeeding a me ka hāpai keiki

E like me ka poe akamai, i ka hoʻohana 'ana i ka lāʻau "valparin" i gestation mea wale nō e hiki ina ka Manao iho la ia pomaikai a hiki i ka wā e hiki mai makuwahine me ka nui loa aku i ka Loaʻaʻia kamepiula a hiki i ka bebe.

I ka loaa ana o ka lāʻau i hāpai keiki, eʻoiaʻiʻo, e hoʻomaka i ka hana kūikawā prenatal ka mālamaʻana o ka fetus.

E ho ohana ana o ka lāʻau i lactation ua ole paipai.

i kekahi Mau 'ike

Mua oe i hoʻomaka lapaau ana o na dala, eʻoiaʻiʻo, e kukakuka pu me kou kauka.

Ma ke kaʻina hana o ka loaa ana anticonvulsant lapaʻauʻia pono regular ka mālamaʻana o ka bilirubin i loko o ke koko, a me nā amylases platelets, e like me ake transaminases (kela 3 mahina).

E like me ka poe akamai, valproicʻakika mea hiki ke inhibiting platelet aggregation. He nui maoli ka pilikia o ka mahuahua koko coagulation manawa no ka kahe ana ke koko. He mea pono e lawe i loko, no ka likelihood o complications mea i pili me kahe ana ke koko i loko o ka postoperative manawa, ma ka poʻe loaa paʻakai valproate.

Inā lōʻihi-makahiki lapaʻau o keia k i loko o nā mea maʻi e hoʻomōhala noho'na makaainana i ulu kahe ana ke koko a me ka hematoma hana. Ma kēia hihia, na huaale e e pani koke.

E like me ka olelo ma luna, paʻakai valproate, he lāʻau pinepine ke kumu no pancreatitis, a me ka paipai 'ana hoʻohuikau o ke akepaʻa kuleana pili i (i hookuu ia ma ka 6 mahina mua o ka nohoʻana). Ma keia manao, i ka hoʻomaka o ka Inc mea pono ke kanaka hoʻoponopono i ke kūlana o ka pancreatic Ka maʻi 'aʻai hoomanawanui, e like me ia mau kanaka hoʻoponopono ake hana ho'āʻo ma, a me ka nui o ka prothrombin.

Kāna hana o ke ake, a hepatic ole i loko o nā mea maʻi e loaa ana paʻakai valproate hiki ke malama i na keiki me ka epilepsy ma metabolic a me ka degenerative maʻi, noʻonoʻo retardation a me ke aloha lolo'aʻaʻa pathology.

Ma ke kilo ana o na hoailona me lethargy, ia nawaliwali, haanou ana, a me ka luaʻi, jaundice, e ike koke nōʻoe, hoʻohana o ka medicament.

Ma ka iapaau ana o "valparin" ka hoʻomanawanui E e loa makaala hana me ka mea pepehi hana ia. O ke kumu ho i ka mea i kaʻeleu medicament mea hiki ke hoemi lehulehu.

Terms a me na kumu o ka pūnaewele

Anticonvulsant huaale "valparin" Hooia ma keʻena kūʻai lāʻau lapaʻau wale ma luna o Kauka ka kuhikuhi. Ka mea, e waiho waho ma ka loaa ole o na keiki a me ka palekana mai ka ona, a ma ka wela o ka i oi mamua o 30 degere.

Ke holopapa ola o ka lāʻau ma lalo noonoo o ekolu makahiki (mai ka lā o ka hana).

Medicament "valparin": analogues, synonyms

Ka lāʻau ma ka nīnau hiki ke auou caiaiai? Synonyms a analogues ma keia mea paahana, he mea nui. O nā nā kēia lapaau: "Apilepsin" "Depakine," "Atsediprol" "Depakine Enterik" "Depakine Chronosphere" "Depakine Chrono", "Dipromal", "Konvulsofin", "Konvuleks", "Orphir" "Enkorat", "Everiden", "Enkorat Chrono".

Like o ka hihia a me "valparin", E e ia kēia mau kālā wale nō ma luna o kauka mau kauoha, ma ka paipai dosages pololei.

Ka manao ana o nā mea kūʻai mai a me ka 'Oihana

He aha kauka i aku nei au e pili ana i keia ka lapaʻauʻia, e like me "valparin"? House poe akamai i ka hōʻikeʻana o ka lāʻau ka loa a me ka pono efficient, pakahi aku la ia i loko o generalized a me ka hapa epilepsy.

Like no nā mea kūʻai mai, i ka hapanui o ia 'aelike i ka manao o ke kauka. E hoomanawanui i hoʻopaʻapaʻa ana i keia loaa o ia hoʻi, kōkua ai i nā ka kokololio kūpono 'ana a me ka palahalaha ae uhi excitation (epileptic) ma neurons. Naʻe, ka mea e e hoʻomaopopo i ka hana o keia k Ua pinepine ke kumu noʻaoʻao ole. E like me ke Customer manaʻo, ka loa olelo ike adverse reactions i: ili allergy, nausea, anaemia, a me ke kaumaha o koʻu pomaikai ia. Inā e 'ike i kēia mau symptoms lakou e ike koke leka uila i ke kauka.