"Azathioprine": manual, nāʻana, wehewehena, analogs

I kahea aku nei oia no ka lāʻau "Azathioprine"? Na Ke Kumu ma o ka palapala noi i hoʻouna 'ia ma ka Luna e e ho'ākāka' ia i loko o kēia 'atikala. E hai mai hoi oe, ina paha he mau contraindications a me analogues i keia k, mea ia na koina, nā mea e hiki mai ma ka hihia o ka overdose, a no laila, ma luna o. D.

Haku mele 'ana,'ōpala, kinona, hōʻikeʻano medicament

Ma ka palapala i loaʻa lāʻau "Azathioprine"? Na Ke Kumu no ka hoʻohana paipai i keia lapaau mea i loaʻa ma ka papa palapala. Kā lākou hana 'Oponopono hana like azathioprine. ¶ A i loko o ka lāʻau, a komo i loko o nā nā mea hoʻohui i loko o ka palapala o kaʻuala pia, gelatin, lactose, a me ka kalipuna stearate.

Ma ka AEeAaOA kuai lilo aku la i ka lāʻau "Azathioprine"? Na Ke Kumu no ka hoʻohana ana i ka lāʻau 'ua puni iho la ia ma ka pepa pahu, a hoonoho iho la haikea yellow Valium huaale ma blister he huihui' ana o 50 apana.

Pharmacological ano o ka medicament

He aha ka keia lapaau like "Azathioprine"? Na Ke Kumu no ka hoʻohana 'ana, maoli inā pilikia ka haumāna' Oihana hoakaka i ka lāʻau ma ka ninau o ka Analog "hypoxanthine", "Adenine" a me ka "guanine", pū i loko o ka 'ole o ka nukelea nāʻakika, a ho'āʻo i kekahi wahi ia i pili i ka'aʻaʻa ka hoʻonuiʻana a me ke kelepona hele mahele.

"Azathioprine" - immunosuppressive Agena. Kona hana ua pahuna ma ke kelepona hele cytotoxicity.

Noʻonoʻo i ka lāʻau hiki ke inhibit i ka naoh o'aʻaʻa incompatibility, a pili i ka replication o nā mea'aʻaʻa, akā, wale i ka meaʻuʻuku loa. Ke hoʻohālikelike me "mercaptopurine"ʻeleu lāʻau hōʻike he oi hai.

Pharmacokinetic lāʻau

Ma hope o moʻolelo lāʻau ua pono ke kemu, mai ka gastrointestinal'āpana. Ua loaʻa he haʻahaʻa hoopaa me ka wai koko nā polokina (30%).

Ke biotransformation o ka lāʻau kalaʻana ia lŘlŘ me tioinozinovoyʻakika a me ka mercaptopurine (a laila,ʻeleu metabolite). Ka uuku dala o ka lapaʻauʻia i loko o ka'aʻaʻa. Ma keia hihia, he uuku lehulehu o ka lāʻau i loaʻa i loko o ka lolo.

Ka hapa-ola o ka azathioprine, a me konaʻeleu metabolites mea e pili ana i 6 hora. I ka lani kiekie loa lehulehu o ka lāʻau i loko o ke koko ma hope o ka malamaia 70-110 minuke.

Ka lāʻau 'Ua aneane loa hookuu pu me bile, a wale 1-2% - ma nā puʻupaʻa.

nāʻikepili papa

He aha prescribers "Azathioprine" (kuhikuhi no ka hoʻohana 'ana ai', analogs, hōʻike manaʻo e e hōʻike hope)? Kēia kanaka e hoomakaukau i hoike mai ai ia ia iho, ka pono, i ka wa o ka kēia abnormalities:

• psoriasis;
• rheumatoid arthritis;
• ulaula systemic lupus erythematosus ;
• ulcerative colitis;
• dermatomyositis;
• myasthenia gravis;
• Pemphigus konaʻena;
• periarteritis nodosa;
• Crohn ka maʻi ;
• glomerulonephritis, autoimmune;
• maʻiʻeleu hepatitis;
• Reiter ka maʻi pale ;
• purpura idiopathic thrombocytopenic.

Ua E hoi e kaulana i keia laau ua pinepine hoakaka no ka Kāohiʻana o ka transplant rejection. Akā, i loko o keia hihia ka mea, ua laweʻia i loko o ka hui pu ana me nā lāʻau.

Contraindications i ka hoʻohana 'ana o ka ai'

Na Ke Kumu no ka hoʻohana ana i ka lāʻau "Azathioprine" hoʻomaopopo 'o ia nā mea maʻi e pili ana i ke kēia contraindications:

• hepatic ole ;
• hypersensitivity i ka hana a kākoʻo eiiiiiaiou ka lapaʻauʻia;
• i hāpai keiki;
• i ke ano o ka mea hoʻokaumaha hematopoiesis;
• na keiki o ka makahiki;
• breastfeeding.

Medicament "Azathioprine": laʻau heluna a me ka hooponopono

E "azathioprine" papa e wale nō e lawelawe hōʻike waha. Ma kēlā me kēia hihia, i ka mahele lāʻau o ka lāʻau me ka nānā 'pākahi, ke kaumaha ma muli o ka loaʻa kekahi hōʻike, e like me ka oolea o ka mai, a me ka concomitant Inc.

No ka mea Kāohiʻana o ke pakuiia auanei lakou rejection ka lapaʻauʻia i hoakaka ia ma ka hui pu ana, me ka "cyclosporin" a me corticosteroids. I ka hoʻomaka o ka lawe ana ka lapaʻauʻia Inc i loko o ka hoʻouka mahele lāʻau i mea 5 mg no kg (no elua mahina). A laila lawe ka lapaʻauʻia i loko o ka hoʻoponopono mahele lāʻau (1-4 mg no kg i loko o 3 nā māhele). Nō kāu, ua lapaʻau ua hoomau no ka lōʻihi manawa. Inā e ana i ka Inc mahele lāʻau o ka lapaʻauʻia ua kuu iho ke kiʻekiʻe.

Ma hanana o ka hoailona mua o ka rejection o transplanted hui, ua koi 'ia e hoʻonui i ka kela la laʻau heluna o ka medicament hou i 4 mg no kg.

No ka iapaau ana o nā maʻi medicament maʻamau lawelawe i loko o ka kela la i keia mahele lāʻau o 1.5-2 mg no kg i 4 māheleʻia nā māhele. Inā pono, hiki e mahuahua i 200-250 mg ka hoakaka dala o ka lāʻau (māheleʻia i loko o nā māhele 4). Ka lōʻihi like 'ole o ka hana maikaʻi a me keia mea paahana ua waiho pākahi, he hoao ana i ka hoʻomalu.

Pehea e hoʻohana "Azathioprine" (papa) i loko o rheumatoid arthritis? Na Ke Kumu no ka hoʻohana 'ana, lākiō i (i ho'ākāka' ia e hoomakaukau ai i hōʻike mai iā ia ma luna) hākālia nō ia no ka iapaau ana o na mai i hoakaka ia 1-2.5 mg no kg no lā (māheleʻia i loko o 2 nā māhele). Duration o Inc E e ma ka liʻiliʻi loa 3 mahina. Like kākoʻo i ka hoʻomanawanui ua haawiia mai i kekahi mahele lāʻau o 0.5 mg no kg (hookahi mahele lāʻau).

No ka iapaau ana o ka maʻi hepatitis B (hana) i hoakaka ia i kela la i keia mahele lāʻau o 1-1.5 mg no kg.

Hihia o ka lāʻau overdose

He aha e na symptoms o overdose ana ma ka hewa? Eaia "Azathioprine" ia waiʻona? Na Ke Kumu no ka hoʻohana 'ana, maoli inā pilikia ka haumāna kauka hoakaka ia ka mahele lāʻau kiʻekiʻe o ka lāʻau i i likeʻole dyspeptic moku'āina, pancytopenia, kāna hana o ke ake oihana a' ō o ka 'ē aʻeʻaoʻao ole o ka lāʻau.

E like me ka hana maikaʻi o kaʻike manaʻo ka hoʻohana symptomatic Inc. Inā pono, hemodialysis. Eia naʻe, e makaala i keia hana, aole ia i kumu hoʻomalu i ka piha hoʻopau o ka hana waiwai, mai ke kino.

lāʻau hana kūleʻa

Like 'ē aʻe ai' e loli ai i ka lāʻau ' "Azathioprine"? Na Ke Kumu no ka hoʻohana Hawaii i Makeke-hooponopono o ka Agena me "Allopurinol" hiki ka hōʻoi 'i kaʻawahia' ole o ka mea mua, a me ka huipūʻana me ka "ke kākoʻo '-trimoxazole" pinepineʻo e māhuahua myelotoxic loa.

I ka wā hoʻokahi lapaʻau me ka ACE nā mea kūpale maoli i ka pilikia o ka loa leukopenia.

Ma ka hui pu ana me nā immunosuppressants (e laʻa me, "Cyclosporins", glucocorticoids, Anati-CD3 nā mea'aʻaʻa) loa pinepine i keʻano o nā neoplasms a me nā mea palahēhē.

Nānā akula au i ko lakou hoomakaukau ana hōʻike antagonistic hookoia e nedepolyarizuyushim Muscle relaxants.

Ua E hoi e kaulana ia vaccination i lapaʻau "azathioprine" hiki kokoke eaaei e alakai i ka suppression o ka? Iecaianoaaiiie o nā mea'aʻaʻa (ma ka hihia o inactivated vaccines), e like me ka hoomahuahua i mea hoʻomaʻi replication (me ka hoʻokomo 'ia' o ola vaccines).

kekahi koi

Mea e ike mua oe i koi 'ia ka lapaʻauʻia "Azathioprine"? Na Ke Kumu no ka hoʻohana 'ana, maoli (analogues lapaʻauʻia helu' ia ma lalo nei) moku'āina i ka elua mahina o ka Inc mua iloko o ua koi 'ia kēlā me kēia pule, e malama i ke kumu o kaʻike ākea koko. Ma hope iho o kēia manawa, ke study hōʻike i nā eiiiiiaiou me ke alapine (frequency) o 1 kela 30 lā.

Ua mea no hoi e pono ai ke kanaka hoʻoponopono i ke kiʻekiʻe o ka bilirubin, 'ākilikai phosphatase a me ka ake nā'ūhū.

Ma ke alo o nā abnormalities o ka hakuʻala a akepaa, me pono me he ami? Eaia me ka pono e hoemi "Allopurinol" medicament laʻau heluna ma lalo o noonoo i 1/4 hapa.

"Azathioprine" me ka lōʻihi mālama nui i haawi ai i ka poe e hoomanawanui i ka mea he mea herpes zoster, chickenpox, xanthine oxidase deficiency, a i ka pāhawewe a cytotoxic Inc.

Analogues a me ka lāʻau kumukuai

He aha e puku "Azathioprine"? Na Ke Kumu no ka hoʻohana (ke kumukuai o ka laau helu 'ia ma lalo nei) Hawaii e i noʻonoʻo i ka lāʻau, he mau na¯. Ke loa i 'ano like ma ka hopena loaʻa nā kēia lapaʻauʻia:

• "Alpha-fetoprotein."
• "Alfetin".
• "Stemokin".
• "Profetal".
• "Revlimid".

Like no ka uku, alaila, o ia huahana mea,ʻaʻole loa kiʻekiʻe. 50 o na papa io "azathioprine" ma awelika e ma kahi o 230 Lūkini rubles.

Reviews o medicament

A mau hōʻike manaʻo o ka lāʻau "Azathioprine" 'o ia hoʻi hui. lawe i ka lapaʻauʻia no ka mea, o ka autoimmune maʻi kekahi kanaka, ua maona a me kona pono ka waiū a me ka nele o ka loaʻaoʻao loa. Others, nae, e hoomanawanui i ka mea, i ikeia e kekahi hopena, a nolaila, hoʻoholo ka mea, e haawi aku i ko lakou koho ana i kekahi 'ano.

It E e kaulana ia a pau na nāʻikepili no ka hoʻohanaʻana i ka lāʻau "Azathioprine" i kapa i ka maʻiʻano nui no ka i kūpono Inc hiki wale nō ia i ka hoao ana i ka 'oihana. Ma keia manao, ma ka hihia o ka hoʻohuoiʻia o ke alo aku o kekahi maʻi mai ka luna papa, e pono undergo i ka hulina 'inikua ninaninau,ʻaʻole i ka pakiko-lapaʻau.