"Carvedilol": hōʻike manaʻo. Na Ke Kumu no ka hoʻohana ana i ka lāʻau, analogues, kuai

Ma ka papa inoa o ka imi-ma hope o cardiac hoomakaukau "Carvedilol" He lōʻihi manawa e hiki mai. House poe akamai i kakau ia e like me ka kiʻekiʻe-kbps iapaau ana no ka hoʻokō 'ole' ka naʻau a me ka hooponopono ana o ma ka od wahi iloko o atrial fibrillation. Ua hoi hiki ke hoʻomano hoʻohana no ka iapaau ana o ka hypertension, aʻo ka mea he nui loa waiwai lāʻau. No keia kumu, he nui mea lāʻau lapaʻau poʻe synthesized a kuai nōhie "carvedilol". Kēlā me kēia no ia i kona ano iho o ke kalaʻana aku a me ka hoʻokumu o pākōlea koko nā hoʻohui like. 'Oiai, ma kekahi mau mea, hana lākou hana.

Mai a pau o ka lāʻau "Carvedilol" counterparts i ka ia waiwai waiwai,ʻaʻohe mea'ē maoli keia mea i ka lakou mea e koho no ka lapaau. ʻOiai haʻawina hōʻike bioequivalence, i kanaka hoomaemae lole a me softer hooko i oi pipiʻi nōhie a me ka palapala lāʻau. No ia mea, ke AIM o kēia hōʻike o ka oi ka pono koho analogues me kiʻekiʻe pākōlea waiwai.

System ano medicament

Like pākōlea konohiki, "Carvedilol" analogues a me nōhie ai 'i ai ka hoʻokō. Hekikai no lāʻau waiwai pili ana i ka papa o ka poʻe'ē he-blockers. Ka mea, i inhibited ma nāʻano o ka adrenaline a me ka noradrenaline receptors: Alpha a me ka Hoʻokolohua-receptors o keʻano mua. Ka mua aia i loko o ka naʻau, a me ka lua o ka - ma na nāʻiʻo o na moku koko. Inhibiting ia lakou, i ka lāʻau stimulates ka ulu ana o kekahi mau pākōlea loa.

Mawaena o blocker papa o ka ai 'o "Carvedilol" Aia nō i analogues o ka lāʻau. Aia mea wale nō i like ka waiwai ma luna o nā maomeka o ka hana. Ma 'ana, i ka lāʻau' hea ka "Nebivolol", kekahi me kekahi hanana hopena. Aia mau no hoi oi poe noonoo ole ka papa counterparts. Ka mea, imua o cardioselective, i mea e wae me ka pili ana i ka Hoʻokolohua-adrenergic receptors o ke 'ano mua, "metoprolol" a me ka "bisoprolol".

Ke hoʻohālikelike i "metoprolol" "Carvedilol" oi e wae no ka Hoʻokolohua-receptors, e hoike ana i aneane like loa "bisoprolol"ʻo Solomona no cardiac Hoʻokolohua-adrenergic receptors. Ma keia la hoomalolo "Carvedilol" ia mea no hoi he ikaika antioxidant. Kēia keia mea loa nui no ka remodeling o ka vascular pa, ua loli ana ma ke kaʻina hana o ka atherosclerosis. E like me ka nui o keia kākoʻo waiwai o ka lāʻau i hāʻawi mai i ke kūlana hiʻona o "Nebivolol." Ua hoʻololi i nā hana ho'ā hope azotzavisimyh endothelial aʻe, a no ia mea, ua hiki ke pale atherosclerotic lesions o arteries.

Pharmacodynamics "carvedilol"

Hoikehonua, lapaau "Carvedilol" aie a hiki i ka hopena o ka Hoʻokolohua blockade o ke 'ano au i ka hahai ole:

• ho'ēmi i kā myocardial contractility ma ka hoemi i ka pono no ka cardiac Muscle kino a me ka oxygen ma (antianginal);
• Ua hiki no inhibiting automaticity a me ka conductivity (antiarrhythmic hana);
• Ua inhibits ka renin-angiotensin nenoaiu o ke kino (antihypertensive ai);
• ho'ēmi i kā ka hapa iki o ka cardiac auaiaea e emi systolic ke koko;
• hiki ke hoʻonuiʻike ākea moku kahi moe.

Ka mea hope ole, Ua olelo ikaika mai characterizes "Carvedilol". Reviews o ka maʻi pono o ka lāʻau hoike he blockade o na waiwai o adrenergic Alpha-hoʻokahi subtype. Ka mea, i ke aupuni 'o kaʻike ākea, oa Muscle moku. Lākou blockade hele aku ai i dilation o ka poe liilii, arteries. Kēia hoʻonāukiukiʻana mai o ka kulu i ka huinaʻike ākea pele ia'ku, kūpono ana ma lalo ke koko, a me ka hoʻoikaika 'ana i Muscle mana.

A like ai i ka "Carvedilol" analogues a me nōhie ai 'ole wale i loko o skeletal Muscle, akā, i loko o ka naʻau. Kēia haʻalele i ka manawa kūpono o ka hana i loko o nā mea maʻi me ka maʻi naau e hemahema, triggered e maʻi ischemia (coronary artery maʻi). A mahope mai o "Carvedilol" mea 1 e wae Hoʻokolohua-blocker me ka kekahi Solomona no Alpha-1-receptors a me Anati-oxidant ka waiwai, kona hoʻohana like kaiāulu.

Ka hoʻohana o "carvedilol"

Mai ka pharmacodynamic ano o ka lāʻau pono maoli nō i emi iho "Carvedilol", hōʻike manaʻo o kona palapala noi e kekahi hoʻokūpaʻa mau hopena a ole, e hōʻoleʻia kāna erroneous hoopai. Ka maikaʻi 'ole o ka lāʻau i mua, ua hoao aku au ia, no ka refutation mea,ʻaʻole paha i kekahi o na olelo. No keia kumu, "Carvedilol" pono keia mau mea me ka lāʻau koi 'ia i loko o ka hahai lapaʻau wahi, i hiki:

• ischemic cardiac maʻi;
• maʻi naʻau ole;
• tachyarrhythmia;
• angina, huʻi myocardial infarction, lolelua ka angina;
• hypertension.

hoike

No ka hoʻomäkaukau ' "Carvedilol" nāʻikepili i uē helu mai kona pharmacodynamic ano. Ma muli o kaʻanuʻu ke koko,, ke emi pre- a me afterload i loko o ka myocardium, a me kekahi no ka mea, o ka mea antiarrhythmic hopena o ka lāʻau hiki ke hoʻohana 'ia i loko o ka hihia o na kēia mau maʻi:

• hypertension II a III degere i loko o ka haku mele 'ana o ka ohe.' O ke kaulike hui;
• ka papahelu aʻu hypertension ma kiʻekiʻe mea'ōnaehana mānowai koko kamepiula monotherapy;
• me ka tachyarrhythmia: atrial fibrillation paʻa palapala, me ka pinepine supraventricular arrhythmia;
• i loko o coronary naau maʻi me ka huʻi hoikeana (lolelua ka angina ole myocardial infarction);
• me IBS He huʻi hanana (ho'āʻo pono angina, angina e holumua ai);
• maʻi naʻau 'ole, mai ka kahua o HIIA Vasilenko-Strazhesko a FC NYHA III ma ka' O ke kaulike haku mele 'ana o ka hui lapaau;
• ma symptomatic hypertension a me ka sinus tachycardia pili me ka hyperthyroidism paha pheochromocytoma.

Na huahana "Carvedilol" counterparts i kapa hoʻohanohanoʻia na nāʻikepili o kaʻikepili. Ka mea, i hoʻohana 'ia i loko o ka loa, he pono ole cardiac maʻi, oa me ka coronary artery maʻi a me ka naʻau' ole. Nō hoʻi, i ka lāʻau, he mea no hoi he nui laulā o ka palapala noi. He nui arterial hypertension, eia nae symptomatic, hoʻonāukiuki hyperthyroidism a pheochromocytoma, a me ka pono hoi malalo o ko Hoʻokolohua-blockers.

Contraindications

I loko nō o ka lehulehu pākōlea holoʻokoʻa ma mua o ka mea e wae Hoʻokolohua 1-blockers i loko o ka lāʻau contraindications noho, ke kaupalenaʻana kona palapala noi. "Carvedilol" hiki ole ke hoopauia i lapaʻau hana ma lalo o ke ana ma lalo nei:

• asthma, COPD, no ka mea, o ka mea mahuahua pilikia o ka bronchospasm;
• Ua Ua papaia e lawe "Carvedilol" ma ke alapine (frequency) o ka emi o 50 naau kui iho oe a no minuke no ka mea, o ka pilikia o ka ona bradycardia;
• papaia e hāʻawi aku, a hoʻohana "Carvedilol" ma arrhythmias (CA-aeie, atrioventricular aeie 2nd a 3rd degere) ina ole paʻa pacemaker;
• unacceptable hoʻohana o ka lāʻau i loko o loa ake maʻi;
• pili i ka hiki ole lāʻau i loko o CHF ooieoeiiaeuiiai papa IV, e like me NYHA (HIII e Vasilenko-Strazhesko) aie i ka suppression o decompensated cardiac contractility;
• "Carvedilol" i papaia i hāpai keiki, lactation, na keiki ma lalo makahiki 18;
• inadmissible hoʻohana i nā mea maʻi me ka allergic reactions i konaʻeleu 'Oponopono' ole ke keʻena o ka laʻau heluna palapala;
• hoomalolo mea i pili i loko o cardiogenic kŰia me SBP 85 mm o Hg. Art.

I loko nō o ka mea i "Carvedilol" pane he qualitatively a kŘpa a palekana lāʻau, ka mea, e like me kēia mau koi. Ua hoʻololi i, e hoomalu aku i ka hoʻomanawanui, a me ka hoʻomalu mai ka hua'ōlelo i makemake wahi, i hiki. No ka mea,ʻikepili contraindications mau loa a me ka hiki ole ke AOON no o ke kamepiula kiʻekiʻe o ka ona aʻe 'meaola.

ʻaoʻao waiwai

E loiloi i kaʻaoʻao 'ole o ka lāʻau "Carvedilol" pane mea i hōʻike. Nā mea maʻi i loko o ka pilikino auhau o ka lapaʻau a me kaʻaoʻao 'ole. No ka mea, rationally ka nānā 'ana ma luna o ana helu noiʻi. Mawaena o ka loa pinepine adverse loa, hoikeia me ka alapine (frequency) mai ka 1 a hiki i 10%, e like penei:

• ma PNS a CNS i ulu headaches, pōniuniu, Muscle nawaliwali, hiamoe kāna hana, paresthesias me na hoikeana o ka idiosyncrasy;
• mea'ōnaehana mānowai koko 'ole (transient a me ka pinepine bradycardia paha atrioventricular aeie, orthostatic hypotension, i kekahi manawa, lameness ma muli o ke circulatory kāna hana o na nāʻiʻo i loko o obliterating atherosclerosis);
• naehana'ōnaehana: hiki symptoms o dyspnea, nasal congestion, a no bronchial hyperreactivity a obstructive maʻi hiki bronchoconstriction;
• ʻaoʻao 'ole, mai ka digestive'ōnaehana i hoikeia abdominal eha, nausea, maloo waha, diarrhea, a wale kākaʻikahi hana constipation a me ka luaʻi, hiki e mahuahua ake transaminase;
• hematopoietic'ōnaehana mākou ke pane wale kākaʻikahi thrombocytopenia paha leukopenia;
• hiki eczema, pruritus, psoriasis exacerbation kahe, a ke hana wale kākaʻikahi anaphylactoid reactions.

No hoi, no ka "Carvedilol" He He haole waiwai i ka meaola, e hoʻomōhala systemic kaʻawahia naoh. Ua hoike mai ai ia maʻi palū-e like maʻi pale me ka hooulu ana o ka eha i loko o na lala, maka maloo, urinary ae hookaawale. Ma keia manao, "Carvedilol" nui oiʻaoʻao 'ole ma mua o "metoprolol", eia nae ka lapaʻau hopenaʻoi loa mea oi ana i ka mea mua elua.

No hooloihi ae i hoʻohana o "carvedilol"

XIX. Laʻau heluna ano wehe i ka lāʻau '- keia capsules a me nā gula'ā'ī. "Carvedilol" ua lawe koke aku i loko o ka hihia o ka arterial hypertension a palua me ischemic naau maʻi, naʻau ole paha arrhythmia. Ka wahi ho mahele lāʻau He 6,25 mg kekahi manawa i ka lā, i ka mea pono no ka hana maikaʻi hypertension. Ma CHF Inc, coronary naau maʻi paha tachyarrhythmias ua waiho e hoʻohana i ka ho mahele lāʻau o 6,25, palua o ka lā. A laila, ma ka titrating ka kela la i keia mahele lāʻau ua like ia 25-50 mg.

Ka lāʻau 'Ua hiki, a ma ka hihia o ka maikai kanaka ke ahonui, ua noi mau. Ua ua pono i ka mana i ka arrhythmia paha e loihi ai ke ola i loko o CHF. Kēia hiʻona o ka lāʻau, ia ma ka hui pu ana, me ka diuretics a me ACE nā mea kūpale hooloihi ae i ke ola. A me ka mea maikaʻi tolerated ma CHF huaale "Carvedilol" ma mua o "bisoprolol". ʻOiai ka iapaau ana ua koi 'ia e kaohi aku mai ka holoʻana a me ka papa o ka palena papaha hoʻopōʻino hana, hoʻokele hoʻoponopono.

Ka hae hookuu palapala

No ka hoʻomäkaukau ' "Carvedilol" ke kumukuai mea ole ka hoomaopopo ana o ka maikai loa. He nui aku efficient e koho i ka holomua hoʻomanaʻo no ka ua 'Isaaka. Ka hapanui pinepine ia i loko o ka wahi lulu, a Western hale kūʻai lāʻau lapaʻau aʻeo ka hoʻolele 'hohola ekolu ano o ka lapaʻauʻia dosages. Kēia 25 mg, 12,5 mg a me 6,25. Nā papa i piha i loko o blisters a ma polymeric pahu. E ka lapaʻauʻia ma muaʻai, ina koi 'ia mahele lāʻau ka ho'ēmiʻana o ka haʻawina, i ka palaoa.

generics

Nōhie ai 'i mau ai' i pihaʻi me "Carvedilol" i loko o ka ua laʻau heluna palapala i ua kō nā koi o ka bioequivalence ma ka nane hea a hiki i ka palapala lāʻau. Ano, he mea nui o generics ma na wahi lulu hale kūʻai lāʻau lapaʻau market, puunaueia i ekolu waeʻano e like me kā lākou kāki:

• kiʻekiʻe kāki ( "Dilatrend", "Corioli ',' Carvedilol Sandoz");
• ka awelike kuai ( "Karvelend" "Carvedilol Zentiva," "Teva Carvedilol");
• me ka haahaa uku ( "V.-Carvedilol" "Carvedilol Belmed", "Karvetrend", "Karvenal", "Vedikardol").

"Dilatrend" ka waiwai e lilo aku ana o 450-750 rubles, ke kaumaha ma muli o ka laʻau heluna: 6,25 mg - emi o 25 mg. A like me nā mea kū ua malama mau i loko o ka hihia o'ē aʻe ai '. Ma "Corioli" kumukuai o 250-500 rubles, "Carvedilol Sandoz" 300-550 rubles, "Carvedilol Zentiva" - 250-400 rubles. "Carvedilol Teva 'kumukuai 200-300 rubles," Karvelend "- 170-330 rubles," Carvedilol Belmed "- 150-250," Karvetrend "- 170-290 rubles.

No ka hoʻomäkaukau ' "Carvedilol" kumukuai mea,ʻaʻole he anakahi o ka quality, eia nae o ka lāʻau reputable Hookah ia mea kiʻekiʻe. I? Aaieou nuiʻokoʻa ma waena o pipiʻi laweia mai ai 'a me ka wahi lulu, oi hooholo koke i loaʻa analogues pihoihoi. Clinicians pinepine hoohihiaia wale discrepancy ka mua hoʻomanaʻo. No ia mea, ia mea pono e koho i ka nōhie capsules mea e me ka nui loa ho'ēmi i kona gastrotoxicity.

I ole ia nike analogues ho'āʻo i ka ia lapaʻau hana, a ua mana no ka iapaau ana o ka naau a me ka maʻi hypertension. Naʻe, ina o ka hoʻomanawanui i mua loaa kekahi nōhie, a laila ia e e haʻalele, e hoʻomau. No ka mea, ka mea i hoʻohana 'ana i nā' ano o ka laʻau heluna palapala, a me nāʻano o ka hoʻoulu wai koko nā hoʻohui like o ka hana 'Oponopono, ka hope huahana e hoʻololi i kona koena. A laila ia e e subjectively mālama i ka lāʻau 'Aʻole e holopono ana paha' aʻole e hana e like me ka makemake.

papa counterparts

Class counterparts, ka loa piha pili pākōlea koi, hoolilo "carvedilol" Competition ma ka helu o nāʻikepili. Ma mau, ma ka hypertension e e wae ai "Bisoprolol" a me "Nebivolol". Hope, no ka mea, o kona kiʻekiʻe he hiki ole e hoʻohana 'ia e ka hapanui o nā mea maʻi, naʻe ia mea he lāʻau maikaʻi. Inā mākou e hoʻoponopono ai i nā mea a pau cardioselective Hoʻokolohua-blockers, kā lākou pākōlea cia piʻina ma loko o ka moʻo: ". Nebivolol" "bisoprolol", "metoprolol", "Carvedilol",

"Nebivolol" Ua noʻonoʻo pono i nā mea maikaʻi lapaʻau no ka hypertension, a "Carvedilol" - no ka iapaau ana o CHF. None o nā ai 'ole ka ai he nui pono' ole ma o ka holo ana o ka maʻi naʻau ole e like me "Carvedilol." No keia mea, ma ka hui pu ana, me ka diuretic a me ka ACE inhibitor, ia mea hiki ke hohola aku kanaka ola.

"Carvedilol" - ia mea he pono ka antiarrhythmic ai ', ma i oe hiki pono ai ke kanaka hoʻoponopono i ka manaʻo o ka od wahi. He mea nui no ka atrial fibrillation, i ka wa a ka manawa kūpono o ka hoihoi hou ana i ka pāpana, a malama ia mea,ʻaʻole i loaʻa. ¶ A i loko o atrial fibrillation "Carvedilol" häʻawi mai ai iä pāpana ke kāohi i ka holo-i i ka hoʻomanawanui cardioversion.