"Sumatriptan": aʻo no ka hoʻohana, nāʻana. Uluwehi O analogues "Sumatriptan"

He aha ka mea i manaoia lāʻau "Sumatriptan"? Na Ke Kumu no ka hoʻohana ana i ka lāʻau, kona pharmacological hana, a me ke ano o ka haku mele, e ia ke hōʻike i ka iki ae la. Nō hoʻi, i loko o kēia 'atikala e hai aku mākou oe e pili ana i mea ka contra-nāʻikepili a me kaʻaoʻao hopena o keia k mai, i ka mea a kona ki ina hana like o ka palapala noi a me ka laʻau heluna, ina loaa ia ia kekahi analogues, a pela aku.

I ka haku mele 'ana o ka laau a me kona haku mele' ana

Currently, huaale wale hiki ke loaʻa i loko o keʻena kūʻai lāʻau lapaʻau, a nasalʻehu "Sumatriptan". Na Ke Kumu no ka hoʻohana ana i keia mea paahana hoʻolako piha 'ike ma o ka haku mele' ana o ka lāʻau. Kama'āina me ia oe e e hiki i ka manawa.

A ho film kapa komo iā ia papa pihaʻi me na hana waiwai e like me sumatriptan succinate. Me ka pili ana i ka kākoʻo hehee wale, mau loaʻa nā kēia: kalipuna hydrogen posapahate dihydrate, microcrystalline kelulose, giproloza (Klutsel ole hydroxypropylcellulose LF), makanekiuma stearate, mannitol (a mannitol), croscarmellose paʻakai (ole primelloza).

Kaʻeleu 'Oponopono nasalʻehu "Sumatriptan" i lawelawe sumatriptan. Like no ke kākoʻo eiiiiiaiou, ka mea hiki e like me ke kinona o ka medicament kala hoʻololi. It E e hoʻomaopopo i kaʻehu ua hoʻohana 'ia no ka hana e hiki ai i, he pono ole ma mua o ka papa. Naʻe, ka mea, i kā lākou mau nā mea kūʻai mai. E like me ka rula, i kēia mau mea na nā mea maʻi i mea ole oluolu e lawe i ka laau lapaau hōʻike waha.

Ke pharmacological ano o ka lāʻau

He aha nā hiʻona i "Sumatriptan" na papa, a hōʻike manaʻo mākou e nānā hou aku?

I aku la hoomalolo mea he protivomigrenoznoe 'o ia hoʻi. He He maopopo, a e wae agonist o 5-HT1-serotonin receptors, a i IIeEeAIEUIeXAIIUE i loko o ke koko o na moku o ka lolo. It E e hoʻomaopopo i ka lāʻau,ʻaʻole ia ma luna o nā subtypes o 5-HT-serotonin receptors.

Ma hope o ka lawe ana i ka lāʻau 'ia ke kumu no vasoconstriction no carotid arterial moe. Pela, ke medicament "sumatriptan" (papa) e pau ai ke koko intracranial a me extracranial nā'aʻaʻa. It E e kaulana i ka mea meningeal vasodilatation, a me kā lākou nani a me nā kumu o ka migraine i loko o kānaka.

Mākou hiki ole ke olelo ia ma hope o ka hookamaia ana o keia mea paahana, aole nui ia (io) ma cerebral koko pele. Papa inhibit wale nō mea loaʻa hope o ka afferent olona, (lākou a hāʻule pahū) o ka trigeminal nā aʻalolo, i ua aia i loko o ka dura. Kēia ia lŘlŘ aie a hiki i ka emi ana o ka sensory neuropeptide kala.

Ua E hoi e aku la ia i ka lāʻau "Sumatriptan" a me ka "Sumatriptan Teva" loa hoʻopau photophobia a me ka nausea, a i pololei ua hoʻopili i ka migraine ho'āhewa wale.

I ka laulā o ka lāʻau

Pehea koke hele mai i ka maikaʻi ia ma hope o ka hookamaia ana o ka "Sumatriptan" ia waiʻona? Hoike o keia medicament pihaʻi me 'ike i ka lāʻau hoʻomaka e hana wale nō ma hope o 30 minuke. Pela ka hoʻomanawanui e lawe i kekahi mahele lāʻau o 100 mg. Incidentally, i loko o 50-70% o nā mea maʻi i koke eliminated migraine ho'āhewa wale ma hope i 25-100 mg o ka lāʻau. I ka lā ma 1/3 nā mea maʻi relapse, a pono i ka hai waiwai o ka lāʻau.

Pharmacokinetics

lāʻau "Sumatriptan" Pehea la ka loihi o ka paka? Ke pane i keia ninau ua i loaʻa i loko o ka'ōlelo aʻo no ka hoʻohana ana i kālā. Ma hope o ka loaa ana i ka lāʻau i loko,ʻo ia ke kemu aneane koke i loko o ka digestive'āpana. Ma hope iho ma kahi o 45 minuke i ka lehulehu o ka lāʻau i loko o ke koko lāʻau lapaʻau kīnā ma kahi o 70%.

Ma muli o ke kāpili omo a me ka mua-hele pūnao, ke kāpae bioavailability o ka lāʻau i ka wa a lawelawe ma ka awelika 14%. E like me ka pili ana i ka pū'āʻana i ke koko wai koko nā polokina, ia mea loa haʻahaʻa (ma kahi o 15-21%). Ka hapa-ola manawa mea e pili ana 2-hola. Awina loko puleʻAmelika, ma nā puʻupaʻa.

Absorbability o ka lāʻau i loko o kekahi lapaʻau wahi, i hiki

E like me ke akamai, migraine ho'āhewa wale mai ole me ka nui loa pili i ka absorbability o kaʻeleu agena sumatriptan (ma ka 'ai, inu a intranasal hooponopono).

Inā ka hoʻomanawanui ua kupikipikio ake hana, a laila, ma hope o ka hoʻohana 'ana i ka ka lapaʻauʻiaʻo ia e' ike i ka mahuahua nui o kaʻeleu 'Oponopono i loko o ka wai koko. Kēia ia lŘlŘ like me ka hopena o ka hoemi i ka mua-heleʻae.

Nāʻikepili no ka hoʻohana o nā lāʻau

Ma kekahi mau hihia, prescribers "Sumatriptan"? olelo Na Ke Kumu no ka hoʻohanaʻana i ka lāʻau i mea e e lawe wale me ka hoike ana mai o ka migraine (me ka aura ole ia).

Contraindications i ka hoʻohana 'ana o

Inā he mau deviations ka mea, ua pololei papaia e lawe ka lapaʻauʻia "Sumatriptan" analogs o keia k? Au makemake e kuapo ia ma keia manao ma na olelo he mea he nui nui o ka 'ike. Ia mea ke kumu ma mua o ka lawe lāʻau me ia, eʻoiaʻiʻo e heluhelu.

No laila, ka mea i ka contra-nāʻikepili ua hōʻike ka waiʻona? E noonoo oe i ka papa pono manawa:

• mahuahua pā lonoaʻili o ka hoʻomanawanui i nā kumu o ke hoʻomanaʻo;
• ʻelemākule e hoʻomanawanui iki mai (ma 65 makahiki);
• basilar, a oftalmoplegicheskaya palapala hemiplegic migraine;
• i ka wā hoʻokahi? eaia o ka medicament me medicaments i pihaʻi me ergotamine a me kona likeʻole nā mea loaʻa, e like me Mao nā mea kūpale (pāpā mai ka'āponoʻana mea mamua i 14 mau lā ma hope o withdrawal o ka olelo mai ai ');
• coronary naʻau maʻi, a me kēia mea;
• teenage a me na keiki o ka makahiki (18 makahiki);
• angina, me Prinzmetal angina ;
• hāpai keiki, a breastfeeding;
• myocardial infarction, a me e kahe ana ma ka mōʻaukala;
• hypertension (kipi type);
• hypertension (lāʻau type);
• occlusiveʻike ākea artery maʻi;
• epilepsy, me kekahi pathological rula pili me ka haʻahaʻa epileptic paepae;
• ʻaʻa puʻuwai a hepatic ole;
• mapuna hoe a transient moku'āina o cerebral koko, me pele mōʻaukala.

E like me ka olelo ma luna, pono ole e hoʻohana 'ia ka lāʻau "Sumatriptan" i hāpai keiki. Akā, inā i ka pilikia a hiki i ka fetus mea emi mai ma mua o ka pomaikai a hiki i ka makuahine, ka mea, ua paa nae ka hoakaka ana i na wahine i loko o ka moku'āina a me ka poe makuwahine. Eia naʻe, e hana i kēia mea i wale he hoao ana i ka hoʻomalu (i ka lāʻau 'ua lawe pololei ma lalo o kona hooponopono). Ma ke ala, ka mea, ua i paipai e hānai i kāu bebe umauma i loko o ka lā ma hope o ka loaa ana mai la o na papa.

Uluwehi O "Sumatriptan": kauoha no ka hoʻohana

Kēia lāʻau 'Ua lawe hōʻike waha, nānā' ole o ka aiʻai ana. Laʻau heluna ma keia hihia pono e like me 50 mg (ina i nele i - 100 mg).

Inā 'oe olelo e pili i ka nasal medicament "Sumatriptan" (ʻehu), kona mahele lāʻau He 20 mg i loko o kēlā me kēia nostril. Hai hooponopono o ka lāʻau ua 'ae' ole ma mua o mua ma hope o 2 HR.

ʻO kā mākou kela la i keia laʻau heluna no ku una hooponopono mea 300 mg. I ka hoʻohana 'ana i intranasal hoʻomanaʻo, ka mea, ua like pu ia mau nā māhele o ka 20 mg.

hiʻona ka lapaʻauʻia

Ano, ia oe i ike pehea e lanakila i ka migraine. "Sumatriptan" (papa a me kaʻehu) Makuakane pono me ka hana. Naʻe, ka mea e e kaulana i ua ole manao ka medicament no ka prophylaxis o mai la haiahū kūmau.

E ho ohana ana i ka lāʻau 'mea hiki wale nō i loko o ka hihia ma kaʻike, i loko o kanalua. Ma mua o ke kauoha o ka lāʻau "Sumatriptan" nā mea maʻi me ka atypical, aʻaʻole mua diagnosed me ka migraine, pono eʻoiaʻiʻo, e alii ai maluna o mai 'ē aʻe neurological rula hoʻopōʻino i ke kauka. Ua E hoi e kaʻikaʻiʻia ma ka manao e hoʻomanawanui iki mai i kaʻike, ma hope o ka hookamaia ana o ka mea i olelo papa i hoʻomōhala cerebrovascular kāna hana.

Ke alo o abnormalities i loko o ka circulatory'ōnaehana (i loko o na kanaka mua o ka makahiki 40 a me postmenopausal wahine) pono i ka ka mua keia hookolokolo ana i ka mea e hookaawale ia abnormalities o na ipu naau a me ke koko.

Currently he mea 'ike e pili ana i ka hanana o ka' aʻe 'ana o ōhumu, nawaliwali a me ka hyperreflexia ma hope o ka lawe i ka lāʻau, "Sumatriptan" a me ka' ē aʻe ai 'o ka pae mai o e wae nā mea kūpale.

Mua a i lapaau me ka lāʻau hōʻike koi ikaika aku aiʻai ana, e like me adherence i ka ikaikaʻai. Pela, ke hoʻomanawanui E hoʻopau mai kouʻaiʻai i pihaʻi me tyramine waiwai (kokoleka, citrus, cocoa, celery, ai hua pisetakia, me ka waiū, ka pī, a me nā komako). Eia hou kekahi, ia mea pono e haʻalele i ka hoopau ana o kanakaʻona mau nā mea inu, a me ulaula, a me ka sparkling maloʻo waina, Kamapane, pia.

Hoʻokō 'a me ka malama ana i ke ola i loko o Aloha Hawaii mau (hele,' auʻau, eu?), E like me ke alo o kekahi Hobby he hoʻonui i ka muli o ka 'oluʻolu Emotions, a ua ālai' ka hooulu ana o kekahi kanaka ahonui o ka migraine ho'āhewa wale.

Na Ke Kumu ma ka hoʻohana 'ana o kekahi nasalʻehu

Kuai ka inoa o kaʻehu me kaʻeleu waiwai sumatriptan kani e like "Imigran". Kēia lāʻau i ka i kēia māhele.

• mea'ūmiʻi manamanalima;
• he kihi;
• uliuli o ka pihi.

It E ke kaulana i ua ho'ā 'loa koke a wale koke aku i ke pihi uliuli. Ma keia pili ka mea, ua pono ole, e holo ikaika ma luna o ka mea a ke kihi e komo i loko o ka nasal e hooholo ia. I ole ia, i ka piha mahele lāʻau e e hele ma ka lapuwale.

E hoʻohana i ka nasalʻehu, i ke ahonui e lawe i kaʻoluʻolu kulana, e moe ana i lalo, e ku ana paha e noho ana. Ma ke ala, ma hope o ka hoʻomanawanui ka nasal lua ua waiho ia e ua holoiʻia me ka pulupulu swabs.

Wehe i ka blister pack, a wehe i ka lāʻau no ka nasal hoʻohana, e komo i loko o kekahi nostril ka lāʻau pono. Like no ka mea'ē aʻe nasal e hooholo ia, e pono e kaomi i ka manamana lima i ka nasal septum. Ma keia hihia, e hanu ai i ka hoʻomanawanui ma ka waha.

Hookomo i ka piko i loko o ka nostril nasal hoʻomanaʻo e e 1 kenimika. Ke poo o ka hoʻomanawanui e malama pololei,ʻaʻole e hina hoʻi hoʻi. Ma hope o ia, i ka hoʻomanawanui e pani i kona waha a me ka hana ana i ka noho malie a me ka lohi breaths ma ka ihu, a me kekahi i ka wā hoʻokahi pono ka 'Oihana e kaomi ma luna o ke pihi uliuli me kou manamana nui. Ma keia hihia, he kanaka i mea i ke pihi ka loa pilipaa. Akā, i kēia mea,ʻaʻole i ka hihia. Iloko o ka ka pahu kui o ka lāʻau i loko o ka nasal lua o ka hoʻomanawanui, e lohe i ka maule kāhoʻi kani. Kēia 'o ia hoʻi i ka pihi i ana hana.

Ma hope iho o kēia kaʻina hana, i ka hoʻomanawanui ua koi 'ia e oaka ana i na waha, a hanu lohi ma ia. pono hoʻomau Head, e malama pololei. Next, ke hoʻomanawanui, e hana i ka noho malie hanu ma ka nasal lua, a no laila Exhale - ma ka waha (no ka 10-20 kekona). Ua ua pono ole i ka hanuʻoi aku ko lāua kaumaha.

Once ke kaʻina hana ua ana i ka ka pahu kui o ka lāʻau, he kanaka hiki ke haha aku i ka alo o ka ona mau i loko o ka ihu, a me ka poe ilihuneʻaiʻana. Mau ka waiʻona ma ke mea e pilikia ke ola a me ka loa hoʻokēʻai kekahi, spontaneously. Ma hope o ka hookahi palapala noi o ka dispenser hiki ke kāpaeʻia.

Cautions ia ka hoʻohana 'ana

Uluwehi O "Sumatriptan Teva", hōʻike manaʻo o ka i mea maikaʻi i ka nui loa, e e lawe ia me ka lōʻihi mālama nui i Keaukaha o kaa, e like me ka poe i komo i loko o hoʻopōʻino hana e pono e māhuahua holo 'awelika o ka naoh a me ka hoolohe.

ʻaoʻao waiwai

Hiki hoʻonāukiukiʻaoʻao 'ole o ka lapaʻauʻia "Sumatriptan"? Hoomakaukau ana o keia ano keia ano hiki he hoʻonui i ka hooulu ana i ka helu 'ano nui o ka ioʻike manaʻo. E mākou noonoo ia i loko o aku au mamuli:

• kanaka circulatory nenoaiu. Ma ka hapa o ka'ōnaehana i loko o ka hoʻomanawanui haʻahaʻa ke koko, i e malama, myocardial infarction, hulina i kiʻekiʻe ke koko, (IeAUPIIe, IAa IO koke ma hope, inu), tachycardia, bradycardia, tachycardia, a ma kekahi mau hihia, arrhythmia, spasms o ka coronary arteries, transient ECG loli Raynaud ka maʻi pale.
• Ko mākou hopohopo'ōnaehana a me ka pono nā loko. Ma hope o ka lawe ana i ka lāʻau o ke kanaka i 'ike luhi, pōniuniu, nawaliwali a me ka drowsiness. Ma kekahi mau hihia, i ka lāʻau a nā diplopia, ke kāʻili 'ana, ka hanana o flicker lele mua o kona mau maka, nystagmus, ua hoʻemi pilikia makapō acuity, scotoma a me ka helehelena transient lilo o ka hihiʻo.
• Ka digestive'āpana. Mai ka digestion i loko o ka hoʻomanawanui pinepine ike ka luaʻi, dysphagia, nausea, a mahuahua (nīnūnē) ha awina o ke akepaa nā'ūhū, abdominal discomfort a me ischemic colitis.
• Allergy. Ma hope o ka lawe i ka lāʻau, kekahi e hoomanawanui i hai mai i ke ano o ka pruritus, poʻe noʻonoʻoʻole, a me ka urticaria erythema. Nō hoʻi, he mea anaphylaxis, he manao o ka wela, tingling a me kaʻeha i loko o ke poo, kaʻehaʻeha, puʻe, flushing, a me ka myalgia. Intranasal hooponopono o ka lāʻau hiki ana i loko o ka palapala o ka kūloko reactions akemāmā transient ae hookaawale ai ke ahi ka waiʻona ma loko o ka puu, a me ka nasal lua a me ka nasal kahe ana ke koko.

AaOIeIOUIeXAOAaIN me nā ai '

Pehea hana i ka kekahi laau lapaau ma ka laulā a me ka hopena o ka "Sumatriptan" ia waiʻona? Na Ke Kumu, loa, mai ka poe akamai ma keia kumuhana pihaʻi me na kēia 'ikepili. Me ka mea i ka wā hoʻokahi pono o ka lāʻau a me ka medicament "Ergotamine" a 'o ia hoʻi ka hoʻomanawanui ergotaminsoderzhaschimi hiki lōʻihi vasospasm. Ma keia manao, i ka wā mawaena ma waena o nā māhele o kēia mau ai 'e ia ma ka liʻiliʻi 24 hola.

E like me ka noiʻi, he mea ka AaOIeIOUIeXAOAaIN ma waena o ka lāʻau "sumatriptan" a me Mao nā mea kūpale. Pela ua hoemiia mua ka metabolic mämä, a me kona lehulehu, piʻi pū.

Me ka i ka wā hoʻokahi 'ana o ka mai la o Anati-migraine ai', a me ka waiwai e wae serotonin reuptake nā mea kūpale, i ka hoʻomanawanui i ulu nawaliwali, hyperreflexia a nee ōhumu o ka neʻe 'ana.

Overdose o ai '(symptoms, lapaʻau)

E ahaʻia ana ina oe e ole like me ka laʻau heluna paipai e kou kauka? Ka wā excessive hoʻohana o ka la hoomalolo "sumatriptan" nā mea maʻi e mahuahua ma luna oʻaoʻao reactions. Ma keia pili ana, i ko lakou kulana pono kūikawā kilo no ka 10 hola.

Inā pono, he overdose ahonui ua kōkua i loko o ka palapala o symptomatic lapaau.

Uluwehi O "Sumatriptan": analogues, a me ka lāʻau kumukuai

E hoʻomaopopo mai i ke koʻi lipi ma kekahi hale kūʻai lāʻau lapaʻau. It E e hoʻomaopopo i ke kumu kuai o ka "Sumatriptan" o ka lāʻau, hoohalike i ka kekahi, kŘpa a haʻahaʻa. Penei, E i no 50 Auana kapa komo iā ia i loko o na papa io o oukou, e uku wale 170-200 Lūkini rubles. Like no ka nasal o ia hoʻi, i kona kumukuai mea e pili ana i ka ia.

ina counterparts i ka lāʻau "Sumatriptan"? "Amigrenin" - he lāʻau i ua loa olelo lilo e hoʻopau migraine ho'āhewa wale ina o ka luna o ia hoʻi, noho e makou i ka hale kūʻai lāʻau lapaʻau. Ma waho mea, analogues medicament "sumatriptan" o kaʻeleu waiwai i na kēia mau ai ': "Sumarin" "Imigran", "Sumitran", "Migrepam", "Sumatriptan-Teva", "sumatriptan succinate", "sumatriptan Pfizer", "sumatriptan Adifarm "" Sumamigren "," Trimigren "a no laila, ma luna o.

No hoi, me he like nasal decongestants, i mau kāhuna kālai Paipai 'hoʻohanaʻehu "Imigran".

Waho pūnaewele kumu a me ka holopapa ola

A hooku iho la lāʻau E e waiho wale i ka maloo a me ka palekana mai Map wahi. Ke ana wela i loko o ka lumi e ole e oi aku mamua o 25 degere. Ke holopapa ola o ka 'inikua iauaeoia, he 3 makahiki. Ma hope iho o kēia manawa, pono ole e hoʻohana 'ia ka waiʻona.