Thrombophilia - He aha ka mea? Thrombophilia: 'ehaʻeha ka, Symptoms,ʻike, a me ka iapaau ana

Ka moku'āina o ke kino ka susceptibility i vascular thrombosis, a hiki recur a i ka henua, kapa thrombophilia. Ka maʻi hiki e kekahi aaiaoe a loaa. Ke kumu o ka maʻi ua loa pinepine mahuahua koko clotting. Clinically, i ka maʻi i hoike i kekahiʻano o ka thrombosis i loko o kekahi mau wahi. Thrombophilia mea nō he ākea ma ka heluna kanaka, a ia lŘlŘ i loko o kekahi 'ano apau loa. Ka maʻi pono lapaʻau me ka lapaʻauʻia aiʻoki lāʻau lapaʻau ki ina hana like.

Thrombophilia: He aha ka mea?

Pathology pili i ka maʻi o ke koko'ōnaehana, hoikeia ma ka welelau o ka thrombosis a me ka hemostatic kāna hana. Mau recurrent thrombosis ma ka thrombophilia e ia i ka hopena o ka trauma,ʻoki kino, physical stress, a i hāpai keiki. ʻAno o ka pilikia, no ka mea, hiki ke alakai i ka complications e like me pulmonary embolism, hahauʻana, myocardial infarction, hohonu aa koko thrombosis. Pinepine holomua 'ano apau loa i ona.

Research,ʻike, a me ka hana ana o thrombophilia limahana ma kekahi mau wahi o ka laau lapaau. Hematology haʻawina o ka waiwai o ke koko kāna hana, phlebology -ʻike, a me ka hana ana o thrombosis o na aa koko, ae hookaawale koko clots komo vascular surgeons. thrombus ho okumu kūpono i ka hoʻohuikau 'o ka maʻamau koko pele, i ua pu ma ka hooulu ana o ka pilikia olelo i mea pilikia i ka pono. I ka manawa e pale aku i ka pilikia, e pono kekahi manawa e ikea ai ke koko clotting. Ke kūmau no ka wahine, no ka laʻana, venous koko mea 5-10 minuke.

kumu o ka

Makaʻu i i ka hooulu ana o ka maʻi, mau. Ua aneane ae nā kānaka apau ke maka e like me ka maʻi like thrombophilia. He aha ka mea pepehi ana, he nui loa nā mea maʻi i kekahi manawa mai,ʻaʻole iʻike a me ka noi aku i ke kōkua, aole lohi. Aia o kekahi papa inoa o nā kumu i hiki he hoʻonui i ke kūpono 'ana o ke pathology.

Hereditary (ole aaiaoe) thrombophilia ia lŘlŘ like me ka hopena o aaiaoe predisposition i ka maʻi. E neʻe i mua koko maʻi (thrombocytosis, erythremia, antiphospholipid maʻi pale) i no hoi ia i ke kumu no kona ulu ana. Hoʻopōʻino aʻe nā atherosclerosis, Ka maʻi 'aʻai, atrial fibrillation, varicose aa koko, a me ka autoimmune maʻi. Ka pahiki o ka hanana o ke thrombophilia, piʻi pū ma hope o ka hahauʻana a me ka naau hoouka. Ma ke kamepiula ciia, e hoomanawanui i ka poe i obese, e alakai i ka sedentary Aloha Hawaii, e lawe hormonal contraceptives, maiʻai i loko o ka hala ua waiho wale aku no i ka eha nui aʻoki kino. I kekahi kakahiaka nui elemakule i ka maʻi mea pohihihi keia, ka mea pinepine ia lŘlŘ ma mua kanaka. E pale aku i ka maʻi a me ke ano, aole ia i hoʻomaka, ka mea, ua waiho mai ka manawa i ka manawa e hele aku hoao aku no thrombophilia.

lapaʻau kiʻi

Lapaʻau hoikeana a mai wehewehe aku ma ka malimali a me ka ala lōʻihi like 'ole o ka papa, no laila, nā mea maʻi i ole koke hai i nā hoʻololi i ola kūlana haʻahaʻa, a me ka mai e kekahi hoopii. Keʻena hoʻokolohua kiko'î a hiki diagnose thrombophilia, he piha lapaʻau kiʻi i loko o kekahi mau hihia, ia ia lŘlŘ wale nō he mau makahiki hope. Bright symptoms kānāwai ka wā i clot i hana. Ke degere o ka iaʻi o ka moku lumen a me IIeEeAIEUAA o thrombus loli i ke oolea o symptoms.

Arterial thrombosis, a ua kauoha aku e koko clots ma ka vascular lumen o ka arterial kahi moe, pu ma ke kahua o ka thrombus i loko o ka lumen o nā ipu o ke keiki, intrauterine fetal make, mau miscarriages, ho'āhewa wale o ka huʻi coronary insufficiency, ischemic hahau ana.

Venous thrombosis o haʻahaʻaʻaoʻao lapaʻau symptoms hoike mai ai ia lakou iho i loko o ka palapala o ka trophic loli o kaʻili, hanahana loa nani o ka laloʻaoʻao, me ka helehelena o ka eha, aloha o ka naau ma ka laloʻaoʻao.

Mezentealny intestinal thrombosis ia lŘlŘ ka wā i ke koko clot i loko o ka IIeEeAIEUAA o na ipu mesenteric a me ka pu ma na symptoms like kolohe pā holoi, ka luaʻi, nausea, pahi-pahi eha.

I ka hepatic aa koko thrombosis ulu hydrothorax (Budd-Chiari maʻi pale), ascites, edema o ka anterior abdominal paia, a malaloʻaoʻao, pernicious ka luaʻi, a loa kaʻeha ma ka epigastric māhele 'āina.

thrombophilia hematogenous

Thromboses loli i ka moku'āina o ka vascular pa, ā 'inoʻino kekahi mea, a me ka hoemi i ka ia'ku, kōkua' ūlōlohi mai ana i ke koko, a me ka hooulu ana o nā hemodynamic kāna hana i i pili me ka loli ma ka (viscosity) a me ka clotting. Thrombophilic moku'āina i loko o nā hihia pili i ka alo o ka vascular maʻi e like me atherosclerosis, vascular intimal poino, vasculitis toxigenic,'ōnaehana paleʻea a infectious kumu. Mau recurrent thromboembolism paha e ukuia i ka loli i loko o ka waiwai o ke koko ia iho, i haawi mai i ka pono, e olelo aku e pili ana i ka maʻi i kapaia o "hematogenous thrombophilia." pathologies a me ka hooulu ana o ke kino i ka welelau o hou pili i ka hoʻomohala thrombosis, kena ae la ia e abnormalities ma coagulation, hoʻopōʻino koko hemostatic Loaʻaʻia.

Thrombophilia hematogenous i loko o ka molekumu o hiki e congenital a loaa. Ma ka papa kuhikuhiEʻano papa hana pee maʻi i i ke kumu e: conjugated thrombogenic hoʻololi ai, platelet dysfunction, hoʻopōʻino fibrinolysis, inhibition,'āno'ē a nele maila coagulation keakea nui physiological anticoagulant. Eia hou, i kekahi kaʻawale ulu like me ka hopena o ka lāʻau waiwai, aole hoi 'inikua uao ai' iatrogenic thrombophilia.

hereditary thrombophilia

Hoakaka congenital ole hereditary thrombosis hiki ia i ke kumu o ka kēia lapaʻau hoikeana: thrombosis ma ka kakahiaka nui elemakule, thrombosis hihia o pulmonary artery, mesenteric, haʻahaʻa mau lala o kaʻohana mōʻaukala, ka mua Episode o recurrent venous thrombosis mua 30 makahiki o ka makahiki, thrombosis iloko o ka wanaʻao hāpai keiki, thrombotic complications. Hereditary a aaiaoe thrombophilia ua nānā 'ma hope o ka hulinaʻike o nā mea maʻi i i ka pilikia o thrombophilic complications.

Congenital ano o ka maʻi i i kaʻokoʻa ano. Ma kaʻike, a me ka maʻi e lawe i ka mooolelo aaiaoe hōʻailona no ka thrombophilia. Ka mua ololi e ka poʻea pau i ka ulu ana o ka maʻi - he aaiaoe predisposition. Ma keia hihia, ka maʻi e ole ana i loko o ka wa e kaawale aku o kūlana i kāhea i nā maomeka o kona ulu ana. Ka lua - ka mutation o nā'ōewe iloko o embryonic ulu. Markedly hookomo hou mai ia wa mua lehulehu kumumea i kiola aku la i ka'ōewe mutation. I waena o lākou, ka poʻe mea i loko mai o kanaka hana: pāhawewe hoʻomehana honua, ka hoʻohana 'ana o ka ai mea hoʻonui, pharmaceuticals,? Aneie haumia ea (hale Nine Inch, mōʻalihaku, pesticides) manmade au i na ino. He mea hiki ole ke kilokilo i ka ana ma lalo i ka'ōewe hiki e modifiable, no laila, mutagenesis Ua manaoia e e huikau ka kaʻina hana, a ia lŘlŘ ma wale, a i ka hiki e hoʻololi i ka hereditary ano.

Hereditary thrombophilia hiki no hoi ia ia ma muli o ke mall paha genomic mutation o chromosomes ili mai mua hanauna. Aia ua hoʻonoho i ka noho ana o ka maʻi'ōewe: recessive paha Hoʻohaku. I ka lua o ka hihia, ke pathology hōʻike i ia iho i loko o nā mea a pau ana.

lilo thrombophilia

'Aʻole wale nō ili akā, i lilo kêia kanaka i loaʻa i ka maʻi. Ke hoomanawanui ke diagnose antiphospholipid maʻi pale (APS). Ua ua no laila, i loko o ka hapanui o na hihia hoike mai ai ia ia iho, kuai thrombophilia. He aha ka mea, he aha ka mea i ka maomeka o kona ulu ana, a pehea e kaua ia?

Antiphospholipid maʻi pale o ka symptom eiiieaena e hiehie keʻena hoʻokolohuaʻikepili a me ka lapaʻau hoailona. Ka maʻi pu ma neurological kāna hana,'ōnaehana paleʻea thrombocytopenia, fetal poino maʻi pale, venous a me ka arterial thrombosis. Līkaia no ke ano o APS: iniiaiie, kiʻekiʻe a me ka nalu; serological koho: seronegative a me ka seropositive. Maʻi pale aicieeaao ku neoplastic, infectious, autoimmune a allergic maʻi a me ka hopena o ka lāʻau intolerance.

Development APS i ke pili me ka'āno'ē olelo e like me malignant neoplasm (Ka maʻi 'aʻai, lymphoproliferative maʻi, leukemia), nā mea palahēhē (mycoplasmosis, HIV, syphilis), asymptomatic holo AFA, maʻiʻaʻa puʻuwai e hemahema, maʻi o kaʻike ākea arteries a me ka naau kiwikā, ake maʻi, connective'aʻaʻa maʻi, a me ka autoimmune maʻi (Crohn ka maʻi, systemic vasculitis, SLE).

Thrombophilia ma ka hāpai keiki

Ma hāpai keiki, aaiaoe a hereditary thrombophilia pinepine hoike mai ai ia ia iho, no ka manawa mua. Keia mea kuhikuhi manawa a hiki i ka Hekikai o ke kolu, ka placental holo p ÷ ai i loaʻa ma luna o ka circulatory'ōnaehana o ka hou ukana. Ho okumu ana o ke koko clots i ka poʻea pau i ka helu o nā hiʻona o placental p ÷ ai. Ke keiki mea ole capillaries, e komo ke koko i ka makuwahine, mai na arteries, laila, e kahe ana ma ka chorionic villi, kahe ana i loko o ka piko.

No ka mea kino o ka wahine hapai ua wehewehe aku e mahuahua koko clotting, a ho'ēmi i kā ke koko poho i haawi ai i loko o ka hanana o complications e like me miscarriage a me ka placental abruption. Ua ka poʻea pau i ka māhuahua pilikia o ke koko clots, a me ka mea ka i loko o ia moe o ka pilikia. Inā ka mea, e IIeEeAIEUIeXAIIUE i loko o nā kīʻaha koko e alakai ai i ke keiki, māhuaola, hypoxia ia lŘlŘ hooki kahe i ka fetus. Ke kaumaha ma muli o ka nui o ka puka liiiU o na moku koko, a me ka helu o ke koko clots, hiki e ukali e loa complications, premature hanau, miscarriage, hāpai keiki Kêia, malformations a fetal make, fetoplacental insufficiency, placental abruption. ka mea hōʻike, IeAUPIIe, IAa IO ma hope o 10 pule. I ka manawa mua o ka thrombophilia ma ka hāpai keiki ka loa pohihihi keia. Inā ka maʻi e hoʻomōhala ai ma hope o 30 pule, laila ia welau a ma na hihia a pau, placental abruption, placental insufficiency ole loa preeclampsia. Ma nana ke kauka e hoʻolohe i ke koko clotting, mea iki okoa mai o ka hae o ka uku o ka wahine "i loko o ka" a.

lapaʻau '

Ka lapaʻau hoikeana o ka thrombosis hoʻopaʻa i loko o ka? Aaieou hoʻohana keʻena hoʻokolohua (cytological, biochemical, aaiaoe, coagulologic) a me ka vocal 'ana i kūpono. I helehelena a me ke ano o ke kino ke kuhikuhi kēia venous thrombosis (haanou ana). Ua venous a me ka arterial pu e mau koiʻana iā ana na eha, a me ka bloating. I kekahi manawa, i ka ili mahana (venous) maoli i loko o ka'āina o ka IIeEeAIEUAA. I arterial thrombosis hapa kokoke i ka thrombus ua malama emi ma ka wela, cyanosis (cyanosis), pahiʻeha. Mau symptoms - kēia mau mea i ka mua hōʻailona o ka thrombophilia, i mea nui i kumu e kipa i ka hoʻomalu.

'Ana ma ka haukapila lawelawe' ia ka hoʻokolokolo pono study o ka hoʻomanawanui. Mai poina e lawe i ka hoao no thrombophilia, hana vascular ultrasound (e hoʻoholo i ke ano, ka nui a me ka wahi o ka koko clot), e lawe mai Akä naÿe arteriography a me ka venography, e leie aku e localize a noiʻi ana i ka'anatomia o thrombotic keʻano o ka hanaʻana. Nō hoʻi, radiographic ana, radioisotopic ki ina hana like, aaiaoe Ka Ikepili o polymorphisms, i maopopo ai i ka lehulehu o ka homocysteine.

lapaʻau

I ka ninau o ka lanakila i ka maʻi i loko o ia lŘlŘ ka poe iʻalo me kaʻike, o ka thrombophilia. He aha ka mea a pehea e hana me ia me ka mea e hōʻalo ai i ka hopena nui? maʻi lapaʻau E e hulina a me ka pū i ke komo o nā kauka o kekahi mau meaʻai poʻokela pepa: vascularʻoki kino, phlebology hematologist. Ma ke kahua mua ia mea e pono e noiʻi i ka etiopathogenic maomeka o ka maʻi? Acaeoey. Noke hopena o ka iapaau ana hiki ke manaoia ma hope o ka hoʻopau o ka kumu kumu wale. An nui hehee ai o ka lapaʻau kaʻai, i mea e hoʻopauʻai me ka kiʻekiʻe naʻokoko, ka hoʻokumu 'ana o momoma a me ka palaiʻai. Ua? Aeiiaiaiaaia io? I loko o kaʻai o ka maloʻo hua, hua a me ka lau, hawaiian lau nahele.

Lāʻau lapaʻau maupaʻa ka hoohiki ana antiplatelet, i ua complemented ma ka hoʻohana 'ana o ka anticoagulation lapaʻau bloodletting, gemodelyutsiey. Ma kekahi hihia ia mea e pono ke lawe mai i ka transfusion o hou paʻahau wai koko hui me ka heparinization. Hakahaka Inc hoakaka no ka hereditary palapala, i mea ku pono i ka deficiency o antithrombin III.

Easy thrombophilia (koko hōʻike, e kōkua ho oholo i ke kinona), ia me ka lyophilized wai koko (intravenous) a maloo wai koko donation. I loa pepa i hoʻohana fibrinolytic ai 'i ka lawelaweia ana ma ka moku occluded ka hoʻohana' ana i ka catheter. I ka pono e, aʻoaʻo, a me kaʻike, o ka thrombophilia lapaʻau eiiieaen, kaulike ola a me ka efficient ke ola.

Kāohi

I mea,ʻaʻole ia eʻalo me keia maʻi nui a me kona complications, kāohi ana e pale ia e ia ma ke kamepiula. Nā mea maʻi me ka thrombophilia kaʻoi loa halihali wai koko transfusion ma haʻahaʻa nā māhele a me subcutaneous lāʻau "Heparin". Hoomanawanui no prophylaxis e koi 'ia laau lapaau e hooikaika i ka vascular pa ( "Trental" intravenous "papaverine" hōʻike waha').

No ka mea Kāohiʻana a me ka hana o ka thrombophilia ua? Aeiiaiaoaony e hoʻohana hoolaʻi Kids, e like me lāʻau lapaʻau mea kanu. No laila, e emi i ka platelet ha awina, e kōkua kī cranberry a me ka hua waina wai. Rarefy koko ma ka hoʻohana 'ana i ka tincture o Japanese Sophora anoano. Eia hou kekahi, ia mea i makemake loa ia e kaʻai akau, oi hele i loko o ka hou lewa, a haawi aku i ka hewaʻano.