Bisphosphonates (ai '): hōʻike, olelo ao, nāʻana. Bisphosphonates ma ka iapaau ana o ka osteoporosis

Ka wā kanaka iwi i fragile a me ka brittle, a me ka mea hana i loko o kekahi mau maʻi o ka iwi, o ka mea e like ai o ke ola ua me ka nui loa hoemiia. Pinepine fractures,ʻeha i loko o na ami, spine a me ka lala hoʻomaka pu i ka ke kanaka mai'ō a'ō, i mea no ke aha la oe e manao ana i ka olioli o ke ola loa ana, a plunge i manao.

Akā, ko makou pomaikai o ia meʻoe i loko o kēia lā o ka honua i kūikawā ai 'i ka pono, hooikaika mai la hiki iwi'aʻaʻa. He ana ia, a e e kūkākūkā i loko o kā mākou 'atikala. I kapa mau ai ' "bisphosphonates" - ai' i hōʻike manaʻo a hiki i ka manaolana o ka laau no na mea he nui,ʻAʻole eʻole kanaka. E manaoio mai iaʻu, e like me ka hailona! Na Google e hai aku ia oe e pili ana i ka moolelo o keia mau dala, e pili ana i mea e mau ai ka pono, ka mea i ke kumu o ko lākou ola kino ia e pōmaikaʻi ai, e hoolaha aku i ka inoa o na bisphosphonates i ka loa hanohano pono a me ka.

I ka 'atikala e e pono no ka kela mea keia mea. Ma hope o nā mea a pau, a hiki ina i keia la na mea a pau o loko o mea, laila, Eia naʻe, ka mea, 'aʻole i manaʻo ola oe a me kou mau mea aloha, ka mea e mau loa aku. Makahiki e hele ana, me ka hou o ko lākou mau maʻi ua lilo hou a nui. No laila, i ka mea e pili ana i ke kālā no na laau e,ʻaʻole e hana wale. Akā, lawa o ka hōʻeaʻana mai! E ka neʻe ma i ke ao oi nui o ka theme like o keia Haawina.

Bisphosphonates - ai 'no ka iwi ola

E wae pūʻulu o kemikala ai 'e i ka hiki e aeie i ke kino o ka ha awina o osteoclasts (aeee i luku iwi'aʻaʻa), a hoihoi aku uaʻikeʻia ka iwi' ole e like me bisphosphonates.

Hoʻohana 'ia kēia mau ai' mea a ianoiyuaa a ma mua wahi no ka mālamaʻana o nā mea maʻi me ka osteoporosis a me ka maʻi 'ē aʻe mea i brittle iwi. Ua hoi ka loa waiwai o bisphosphonates ka mea i ka mea, i ke hoʻohana 'ia ma oncological maʻi wehewehe aku ma ke kahua o ka hikoko ma ka iwi. Ma kēia hihia, i ka lāʻau, i'ōlelo mākou 'atikala, mai haawi metastases i palahalaha ae, a emi eha i loko o kēia mau hoʻomanawanui iki mai.

Keʻano papa hana o ka hana ana o bisphosphonates ma ka iapaau ana o ka osteoporosis

Ma ka mokuna mua, e aʻo i bisphosphonates - ai 'i ka paipai healthier iwi. He manawa e kamailio hou aku e pili ana i keʻano papa hana o kā lākou hana. Ko makou kino ka aeee i he kupaianaha hiki mai ka manawa i ka manawa e ka moʻolelo, a kūkulu hou. Iwi'aʻaʻa - mea i koe. Koe i ko lakou mau hale i malamaia, ma ka kekahi lima, i ka osteoblast aeee i nā kuleana no ka hana o ka hou'aʻaʻa, ka mea 'ē aʻe - osteoclasts i nā kuleana no kona luku. BF i ka mana, e 'ūlōlohi mai ana i ka hana ana o osteoclasts, a hiki e holo aku au i ko lakou pakiko-destructʻano papa hana. I keia waiwai kamahaʻo a me ka nānā 'bisphosphonate lapaʻau o osteoporosis.

Au pono aku nei au i ka ua i maopopo hoomaopopo ai mamao kānakaʻepekema i ka wahiʻano papa hana o ka iwi poho me ka hoʻohana 'bisphosphonates. Ua ua ike i ka mea hiki ke hoopaa i ka hydroxyapatite iwi pauku, hiki ai ia lakou ke hoʻololi kona anuenue, a ma ka mea ia manawa emi i ke koko lehulehu o ka hydroxyproline a me phosphatases mau waiwai.

I kekahi manawa, BF hoomakaukau i e lawelawe i loko o ka iapaau ana a hiki o ka maʻi e like me herniation a protrusion o intervertebral iwi kuamoʻo, like analgesic konohiki. A he iki hou 'ikepili: bisphosphonates no ka osteoporosis i ua hoʻohana no ka lōʻihi manawa, akā, no ka maʻi' aʻai, ka mea, ua ua hoʻohana nei. Ma keʻano o nā haʻawina mea i loaʻa i ke komo i ke kino, ma ka hana i loaʻa i loko o ka neoplastic kaʻina, bisphosphonates mai e haawi aku i kaʻeho keena coalesce me ka iwi'ōpū mai, a hiki ia inhibit ho okumu ana o metastases. Nā lāliʻi hou e pili ana i keia, e e kūkākūkā i loko o ke kaʻawale mokuna.

A wahi moʻolelo

Ua huli mai i bisphosphonates i loaa ma kaʻepekema no ka lōʻihi manawa, a hiki ma ka XIX kenekulia. No ka mea manawa mua i lawe mai i ka hoʻololi kemikala o ka BF mua i loko o Germany. Ka mea, Ua kahaha ko oukou naau i keia mau waiwai i hoʻohana mua wale nō i loko o nā hanalima nāʻoihana (no ka? Iecaianoaaiiie o fertilizers, i ka hana o fabrics,ʻaila kā hoohehee maemae au ia a me ka e like. D.) A unrelated i ka lapaau ole i.

No ka 'inikua hana - no ka iapaau ana o ka iwi - hoomaka bisphosphonates e e hoʻohana wale i loko o ka hapalua like-iwakalua kenekulia, ka wā eʻike i kā lākou mea kupaianaha waiwai, e ho ololi i keʻano o ka hanaʻana e like me calcification a me ka decalcification. Bisphosphonates no ka osteoporosis hoʻohana mai a puni ka honua i loa kaila.

Mea Maluna o bisphosphonates

I kēia lā, pharmacology hoʻomohala i ke kolu o ka hanauna biosfosfonatov. Akā, i kēia 'aʻole i manaʻo i kauka i haalele loa i ka hoʻohana' ana o ka ai 'o ka mua a me ka lua o ka hanauna, i i invented nui mamua. Aole loa mai ia! I kēia manawa, ua nui na ai 'i i ka nānā' ana ma luna o bisphosphonates. keia ano a pau o na laau ua maheleia i mau pūʻulu: bezazotovye laau a me ka naikokene. Lākou kanawai ma ka osteoclast keena mai he okoaʻano papa hana. Aia ma lalo e nānā mākou i nā pūʻulu i hou au mamuli.

Naikokene-i loaʻa bisphosphonates

Kēia pūʻulu o ai 'i na bisphosphonates, na ka i kēia hana nā mea hoʻohui:

• Ibandronatovayaʻakika. E ka waiwai i synthesized nei, no laila, i ka lāʻau o ke kolu o ka hanauna. Ua Ua hoʻohana 'ia ka hapanui ana i loko o ka lapaau a me ka Kāohiʻana o ka osteoporosis i loko o nā wāhine, ka poe i komo i loko o ka pilikia wā o ka menopause. Men lawe keia k ua i paipai. Ibandronatovuyuʻakika ua i hoʻohana 'ia i loko o pathological mahuahua i loko o ke koko kalipuna (hypercalcemia).
• Zolendronovayaʻakika. I pili i ke kolu o ka hanauna bisphosphonate. Hiki e hana selectively ma iwi'aʻaʻa. Me keia ua pono hoʻohana no ka iapaau ana o ka osteoporosis. Ka mea e wae hana zolendronovoyʻakika ma luna o ka iwi 'ole ua nānā' ana ma luna o kona kiʻekiʻeʻo Solomona i ka osseous puka olu oia i hoʻolako maikai inhibition o osteoclasts. ʻO kekahi mea nui ka waiwai o ka lāʻau - he haʻi Anati-ʻeho kanawai. Ma ke kumu o ka loaʻaʻakika zolendronovoy Popular bisphosphonates "Zometa", "Zolendronat".
• Alendronate paʻakai - i ka lua o ka hanauna mea o bisphosphonates. He He pili-hormonal ilepili proofreader metabolic iwi'aʻaʻa ho okumu i ka pololei 'ole o ka iwi. Ua Ua hoike mai no ka hoʻohana ma ka osteoporosis nā wāhine a me nā kānaka.
• Ibandronate paʻakai ( "Bonviva" "Bondronat" "Boniva" - bisphosphonates hoomakaukau ana ma luna o kona muli) - ka hanaunaʻekolu, ai '. Inhibits osteoclast ha awina me ka mea e pono ai i ka helu o ia. Ua aʻole he kūlana maikaʻiʻole i ke kahua o ka iwi keena, pela ka pono hoemi i ko lakou lukuia'na. Good kōkua ma postmenopausal wahine me ke kāohi Agena o ka iwi fractures.

Hoomakaukau e mai nei no naikokene

Ano mākou, e kālele ana ma luna o ka mea i ka naikokene-noa bisphosphonates. Ai ', a inoa e heluhelu nei, e pili ana i ka hanauna mua o bisphosphonates:

• "Clodronate." Ua 'ano ua ālai nā osteolysis a me ka hypercalcemia ulu. Ua ano he luna 'pilina me hydroxyapatite iwi EUIAaIN ke aniani puka olu oia, a' Imi counteracts ke kaawale ana o ke kalipuna a me ka posapahate nā lātoma. Metastases i loko o ka iwi keakea, i ko lakou ulu ana, a ālai 'o ka hoʻokumuʻiaʻana o nāʻoihana hou.
• "Paʻakai Etidronate". Paipai 'ia ka hoihoi hou ia ana o ka iwi a emi i ka wahine me kaʻike, o "osteoporosis". Ua hiki no hoi ke hoʻohana Paget ka maʻi, hypercalcemia a me ka mea e like. D.
• "Paʻakai tiludronate". Mineralizes a Hoʻoikaika i ka iwi'aʻaʻa, loaa malaila hakakino hui a me ka kalipuna posapahate, inhibits ka make ana o ka iwi. Hoakaka ia i nā mea maʻi me ka diagnoses o ka "ino osteodystrophy" a me "Paget ka maʻi" e e hoonoho ia ma ka hakahaka o hormones.

Bisphosphonates - ai ', i ka papa inoa o ka a mākou i paʻiʻia - kuai lilo wale ma kuhikuhi, i mea e e potent waiwai ... E hoʻohana i ia mau mea ma ko lakou manao hiki e weliweli no kou ola! E hoomanao i BF - mea e noho malie hoi e nā wikamina paha kumukanawai a me ka kalipuna. Mau ai 'i' Imi intervene ma ka keʻano o ka hanaʻana 'ia i loko o ke kino, a ina improperly pili ke kōkua ma ka hakahaka o ka hewa.

komo lula

bisphosphonates ai 'muli o kona kulanaʻelemakule ke kemu ma ka gastrointestinal'āpana, kā lākou omo pilikia. Nolaila, ia mea ikaika aʻo prescribes inu mau ai 'wale ma luna o ka ipu opu, ma kahi o 30 minuke ma mua o kaʻai - ia i hookuu kōkua i ke omo o ka hana lāʻau' ona. Hoʻomanawanui iki mai Pono e ike i keia pae ana o ai 'hiki ana o na la li nui a me ka'aʻaiawāʻana i loko o nā wahi likeʻole o ka gastrointestinal'āpana. E pale i na complications, ma hope o ka loaa ana o na papa io e pono ai, e ho'āʻo iloko o na hora i hele aku, a noho ma ka pololei kūlana. Ka laʻau heluna ua wae mai ma ka hele kauka.

Nō kāu, i ka hookohu o ka bisphosphonates Kauka prescribes ka hoʻomanawanui nō a me ka 'ai, inu a nui nā māhele o ke kalipuna. No laila, i ka wā hoʻokahi? Eaia o nā hoʻokoe '. Hoomakaukau i loaʻa ka kalipuna, hiki e ia ma hope o ka lawe bisphosphonate wale nō ma hope, elua no hora, aʻaʻole ma mua. Kekahi mea nui hoike: CF i e inu i kī, ka waiu, wai a me ke kope, a me ka papu wai (i ka hailona o).

I ka hoʻohana 'ana o bisphosphonates ma neoplastic maʻi

More kamaʻilio e pili ana i bisphosphonate hana maikaʻiʻole o ka maʻi pili i ka ulu ana o hikoko o kekahi ano. Ka hanana o ka metastasis ma ka iwi'aʻaʻa kaʻaoʻao ma kaʻaoʻao a me ka reciprocal AaOIeIOUIeXAOAaIN ma waena oʻeho keena a me metabolic aayoaeuiinoe o ka iwi'aʻaʻa. I huli ai oe, o ka hōʻeuʻeu kūpono 'ana o nā metastases ua pu ma ka mea pīlali o kaʻeho aeee i ka iwi hale, e like me ka pono me kaua, ka hoʻonuiʻana a me ka neoangiogenesis. Lehulehu preclinical haʻawina i 'ae'ʻepekema e e ka mea mahuʻi ia BF inhibit kēlā i kēia mau kuʻina o ka pathogenesis.

Ma ka papa o kekahi mau noiʻi papahana mākou ana kūpono i ka hopena o ka bisphosphonate "Clodronate" ma o ka ulu ana o metastases ma ka iwi i loko o nā wāhine diagnosed me ka umauma Ka maʻi 'aʻai. maikaʻi loa i nā hualoaʻa i loaa: ka hoomakaukau kōkua e emi i ka mea hiki wale mai o metastases a me ka ulu ana o hou iwi'aʻaʻa i loko o nā mea maʻi. Currently, noiʻi ma keia ala e hiki aku ua mau 'Imi. Bisphosphonates ka wā iwi metastases e maoli hiki ke kōkua.

Malignant hikoko pinepine pū 'oe me hypercalcemia (kalipuna hoʻokuʻu mai i ka iwi). Ka wā metastatic lesion o ka iwi kalipuna kokololio poho ia lŘlŘ aie ai i kona luku ma osteoclasts. Eia hou kekahi, hypercalcemia i ka maʻi 'aʻai hiki ia i hoʻomaka ai ma muli o ke waiū i kaʻehoʻakika'amino. Eia, he mea ho'ā hope o osteoclasts, e alakai i ka hypercalcemia. Kēia kaʻina ka huikau a me ka hōʻeleu i no hoi ma ka hoemi ʻaʻa puʻuwai kuleana pili i.

Mau keʻano o ka hanaʻana mai i hoʻomaka ai me na malignancies me squamous ke kelepona hele carcinoma, mau myeloma, umauma Ka maʻi 'aʻai,ʻaʻa puʻuwai halepaahao Ka maʻi' aʻai, a kekahi lymphomas. Hypercalcemia, hoonaukiuki ma ka maʻi 'aʻai, ka loa ka hoʻokō ai' i bisphosphonates no intravenous infusion. Ua pono kukulu ai i loko o kēia mau hihia, ua ai ', bisphosphonates, like "Zolendronovayaʻakika" a me ka "Pamidronate".

Loina hōʻike i mua i kekahi mau lā ma hope o he lālā o ka hooponopono i ka hoʻomanawanui iki mai intravenouslyʻikepili ai 'i loko o ke koko kalipuna lehulehu ka normalized, a me ka hope mau no ka manawa he lōʻihi o ka manawa (mai kekahi a hiki i elua pule).

Ka papa inoa o ka maʻi i loko o i bisphosphonates i hoʻohana ana

• Osteoporosis.
• Myeloma.
• Aʻe 'ana o ka iwi a ho okumu.
• Paget ka maʻi (osteodystrophy ino).
• Helu hyperparathyroidism.
• Hikoko, a metastases i loko o ka iwi, o ka oi aku hui me ka hypercalcemia.

ʻaoʻao waiwai

Eia naʻe, i kaʻeleu bisphosphonate iapaau hiki ole e innocuous. No ia mea, ke hele mai i ka intravenous hooponopono ana i mau ai '. Ka mea, hiki i nā kēia ioʻaoʻao ole:

• I ka lawelawe intravenously, - hypocalcemia.
• Hiki he kūlana maikaʻiʻole i nā puʻupaʻa, i intoxication.
• I kekahi manawa? Eaia Amine biosfosfonatov hoʻonāukiukiʻana mai o ka ulu ana o osteonecrosis o ka iwi ā.
• He hoʻonui i ke kūpono 'ana o ulcers ma ka esophagus, a ma o ka'ōpū.
• Hiki i constipation paha diarrhea, ma ka pohihihi keia hihia - pilikia ma ka moni 'ia.
• General malaise, nawaliwali, nausea.
• Muscle eha.
• Hihio pilikia.
• Rashes ma luna o ke kino.

Ae, a pau o kēia mau pilikia hiki i bisphosphonates. Ai ', o ka inoa o ka mea e hui ana ma keia Haawina, e hiki ole koho iaʻu kū kaʻawale i ole inadvertently i ke kino irreparable ia ia ka poino. Mākou ka noonoo e haʻi hou aku ia kekahi mau manawa ma ke kikokikona! E hoopono ana ma na nāʻana, i hiki ke heluhelu i loko o kekahi Usenet, kanaka i 'Imi kaʻana like' ikepili i kekahi i kekahi, e pili ana i kekahi mau BF a me ka hooholo koke waiho aku ia i ka 'ē aʻe. 'O kēia kekahi unethical. E lawe i kēia mau potent ai 'mea e pono ai wale nō ma luna o ka hoike ana o ka hele kauka a me ka manawa a ma lalo o kona hooponopono.

Bisphosphonates - hōʻike manaʻo o nā kauka, a hoʻomanawanui iki mai

Aole anei oe i ike i kela makahiki, i Okatoba 20, ma nā'āina a pau o ka World Day o ke kaua e kū'ē i osteoporosis? Kēia maʻi i loko o nā makahiki, e loaa i ka io'ōkuʻu huliāmahi. Oiai kekahi poe akamai i manaoio i ka urgency o ka pilikia o ka osteoporosis ua i kekahi mau mea ua höʻike pü, no ka mea, ka mea maʻi mea,ʻaʻole i loko iho ona. Aka hoi, o ka pakeneka o ka poʻeʻelemākule, ka poe make ma hope o ka Hip fracture, a pinepine ka hana i ka wā e ua hōʻeleu i iwi poho ka nui loa. Nolaila, he nui loa o ka poʻe i mau manaolana ma bisphosphonates. Reviews o nā mea maʻi i loaa mau ai 'no ka mea, o ka manaolana o ke ola, imbued me ka mahalo i na kauka a me ke kālā no pharmacology, a ua hiki ke hoolako ia me ka' eleu kōkua.

Dr. Med. , Kumu a me ke poo o ka Ho oholo Wae-lapaʻau Center o ka osteoporosis Svetlana Rodionova manaoio i ke kahua me ka osteoporosis loa lawa ma Rusia. A maikaʻi-ike kauka i olelo mai ia i loko o kā mākou mau lā, i ka wa a ka mana o ka hapa nui o nā poʻe mea hemahema (ka nele o ke kalipuna), e nui hoi o ka makana o ka inoʻano e like me ka uiki e, hoʻohana a ai 'a me ka waiʻona, a me ka physical aayoaeuiinoe ua hoʻomaka koke ka hookokoke ana' Aʻohe, he nui ui kanaka,ʻano nui na wahine i make i oi oo makahiki osteoporosis. No laila, i ka pono no ka maikai pono ka ai ', e kōkua hoola i kēia maʻi ka loa kiʻekiʻe.

Like no ka pinepine kauka o ka manawa i oleloia ai bisphosphonates, i ke Kumu o ka manao i ka mea, ua ole mau hoaponoia mai. Bisphosphonates - hana-ike mai 'ō ai', akā, i ka hoʻomanawanui ma mua kuhikuhi i kekahi kuhikuhi, pono eʻoiaʻiʻo, e lawe i ka mooolelo na aʻe i pūnao o ka iwi a me ka kalipuna homeostasis ke kauka. A hiki i ka paakiki, a kipi bisphosphonate Inc hiki i nui complications: atrial fibrillation, osteonecrosis o ka iwi ā, subtrochanteric fractures o ka femur.

Ma muli o ka manao o ka mahalo kauka, mea ole bisphosphonates he ao panacea, e e hoʻokokoke lākou hoʻohana me ka mālama nui. Ia manawa, i ka polokalamu "Health" ua hōʻike ma kīwī, kahi Elena Malysheva me ka meaʻala minoʻaka e hoike i ka hoolohe ana, aohe mea i hiki pono ma mua o ka e kamailio ana no ka osteoporosis, he kolu-hanauna bisphosphonate. Mai kiʻi he hilinai infomercial. Kekahi kanaka e loaa ana BF ua loa contraindicated. No ka laʻana, nā mea maʻi me ka loaʻaʻa puʻuwai maʻi.

Ano, no ka loiloi 'ia ma luna o ana i ka hana bisphosphonates ka wā iwi metastases. Lapaʻau manao Ua maopopo: He keu maoli hiki ke hooki i loko o ka iwi ulu o malignant keena, a, o ka papa, e kokua hoʻomanawanui iki mai lanakila i kekahi o ka loa loa illnesses, i wale i koe i loko o ke ao nei i kēia mau ai '.

ka hopena

Ano, e ike i ka mea o - bisphosphonates. Na Ke Kumu no kā lākou hana i maiʻaneʻi, e like me ka pono me ka papa inoa o ka ai 'hāʻawi iā mākou,ʻaʻole like me ka hoike, a eia no ke alakaʻi wale - e uku i kou nānā' ana i kēia! Inā mea pilikia e i pono i ka pakiko-lapaʻau i ola, i ka mea maikai - koke ike i kekahi kauka, pela no oia i 'oe i ka' inikua hoomakaukau. Mākou makemake oe i waiwai nui ola kino a me ka pomaikai!