Histidine: haʻilula, Nine Inch reactions

Kēlā me kēia o ko mākou ma ka liʻiliʻi loa i loko o ke ola koke manaʻo e pili ana i kānaʻai. Eia, no ka mea hoike, i ka mea a ka mea i kela la kūmau o likeʻole waiwai e pono ai ma ke kino hele mai ia iā mākou me ka ai? He aha e'amino nāʻakika mākou pono, a no ka mea? I kēia manawa, ua, o ka papa, e ka e kamaʻilio e pili ana i pono no kou kino e like me ka a pau, mai keia wahi kekahi, a hiki i ka kakini 'atikala. Mākou hōʻike wale nō kekahi waiwai, i mea kanalua nui loa no ke kino. Kēia'aminoʻakika histidine. Kona Nine Inch inoa kani huikau - L-2-'amino-3- (1H-imidazol-4-yl) propanoicʻakika. Akā, mua na mea mua.

He aha e'amino nāʻakika?

Ma mua o ka waiwai o ka histidine a me kona kūlana ma ke kino, ua kūkākūkā, e ike mākou i ka manawa "'aminoʻakika". O ka poe i leʻaleʻa o nā haʻuki, ua lohe no kēia mau 'ona. An'aminoʻakika mea he aloha i huiʻia me nā kumu o ooieoeiiaeuiuo pūʻulu i e ka mea kūikawā: ka'amino pae -NH _2, a no laila,-kapa carboxyl pae -COOH.

Ka mea mua i kuleana no ka walaʻauʻana waiwai o keia hana ano o ka hui. Ma muli o ka naikokene a me kona'aminoʻakika paʻa electrons hiki palapala ikaika kauoha Ion. I ka wā o ka'amino pūʻulu ua hoohuliiaʻaneʻi i loko o ia ion: -NH ₃ ^+.

Ka lua o ka iaea ooieoeiiaeuiiai pūʻulu kuleana no ka ʻakika waiwai. He hiki no donating ka proton, e lilo ana anion -COO ^-. Oia ka kŰia mau hiʻohiʻona nō ho okumu i paʻakai me ka carboxylʻaoʻao pae.

Pela, ke'aminoʻakika i mau'āpana, kela mea keia mea o ka i mea hiki ke ho okumu i paʻakai. Kekahi o ia hoʻolako i nā waiwai o kēia hui, nāʻakika, a me ka mea 'ē aʻe - na kumu. I mau, ke'aminoʻakika hiki e na poe like: NH ₂ -CH (R) -COOH. Palapala R e e maopopoʻaneʻi me "'ano'ē", a laila i kekahi ke aloha huna oia hoi o ka ooieoeiiaeuiuo hui a me ka kalapona iwi a me ka hiki ke ho okumu i ka hoopaa (a makaukau na kaula paa) i ka kūpapakū lātoma'aminoʻakika.

E like me ka rula, o ka poe i ole kama'āina me ka pharmacology, a i hoihoi i ka haʻuki, i lohe ai, ma ka liʻiliʻi loa, mai hoʻolaha, i ka'amino nāʻakika mākou e pono ai, a ua nui loa kōkua maikaʻi. E ka hana ka mea hana i loko o ke kino a me ke kumu e pono ai, e komo ia i loko o ka koi ana o ka ai i ka ike.

'amino nāʻakika hana i loko o ke kino

E like me ko oukou ike ana, a pau o ka mai, ua i mai o nā polokina, i ka momona, a me nā carbohydrates. A me ke hoʻopau ia i ka ai, e malama i kona viability. Akā, i ke kumuhana o keia 'atikala, ua hoihoi mākou wale nō nā polokina. Kēia mea he nui lātoma, ae hana i ka pono a me ka okoa loa nui oihana i loko o mākou kino: amo ana o waiwai, ka hanaia'na o ka hou keena, e hooikaika ana i ka loulou ma waena o lolo neurons. ua huli kamaʻilio e pili ana iʻaʻole pono nā polokina. Ka mea i ka mea, i mai o'amino nāʻakika, a e komo histidine a pau kēia mau waiwai. Haʻilula i ka simplest kumuʻiʻo maupaʻa ma ka liʻiliʻi loa he umi'amino nāʻakika, pili i loko o ka polypeptide kaulahao. Kēlā me kēia no ia i kona iho 'ole a me ka shape e leie aku ia, e hana i ka hana no i ka mea i hanaia ma ke ano.

histidine

Ke haʻilula nā kekahi'aminoʻakika, e like me mākou i ike, ma ka liʻiliʻi loa elua ooieoeiiaeuiuo pūʻulu a me ke kalapona iwi, ai pili aku ia lakou. Ia mea ke kumu o ka likeʻole ma waena o nā mea a pau i ka'amino nāʻakika (a, incidentally, ua mua i loaʻa he mau miliona) o ka lōʻihi o ka kalapona uapo ma waena o nā hui 'elua i loko o ka'ano'ē' ole, adjoint ia ia.

Ke theme like o keia 'atikala - o kekahi o ka'amino nāʻakika - histidine. Haʻilula kēia paʻa mauʻakika pilikia. Ke kumu nui i carbon kaulahao ma waena o nā loiloi pūʻulu elua ke ike wale kekahi o carbon'Ātoma. I mea, a pau nui proteinogenic (hiki no e pili ana nā polokina)'amino nāʻakika i wale kekahi i carbon'Ātoma i loko o ke kaulahao. Eia kekahi, histidine i ka huikau 'ole'ano'ē la i komo ai kalapona. Ma luna o 'oe ke ike i ka mea he histidine. Ke haʻilula, i ka mall hiʻona o ka i ninoieo ma ka heterocycle (hoʻi o kekahi'ē aʻe nā'ātoma ole kalapona), mea nae i ka hardest waiwai.

No laila, koke mākou ana no ke kumu o manaÿo, e ka neʻe i na reactions e hiki e lawe lakou ia lakou iho me ka histidine.

Nine Inch mall

No AiON, a lawe i kēia'aminoʻakika, Ua pohihihi keia. Hou reactions me nāʻakika a me nā kumu, e komo i loko o ka biuret naoh e lilo i nā pōpō huahana. Eia kekahi, histidine, kona haʻilula kikowaena i ke reacted me sulphanilicʻakika ma Pauli naoh residues o imidazole.

ka hopena

Paha a pau o ka nui 'ikamu mākou dismantled. E manaolana aku kakou i ka 'atikala ua pono ia oe, a haawi aku la oe i mea hou ka ike.