Ka lāʻau "Klayra": hōʻike manaʻo o nā kauka, pros, Con, kauoha,ʻaoʻao 'ole. Waikiki gynecologists e pili ana i na papa "Klayra" no ka endometriosis, ma ka menopause

I kēia mau lā, ua kākau nā kauka lapa'au hou i ka lā'au "Clayra" no kekahi mau ma'i. Nā'ike e pili ana i nā kauka, nā hui, me nā hana o kēia hō'ailona -'o kēia mea a pau e nānā'ia ma lalo nei.

Pehea lākou e hana ai?

Kēia lāʻau 'He He hoʻohui pūʻia ku una contraceptive, i ua muli ma ka AaOIeIOUIeXAOAaIN o kekahi mau aʻe. 'O ka mea nui loa i waena o lākou,'o ia ka ho'opi'i'ana i ka'ōlohelohe, a me ka ho'ololi'ana i nā waiwai o ke kolo o ka pēpē -'o ia ke kumu no ka hana o ka lā'au lā'au "Clayra". Ho'ohālikelike nā'ōlelo a nā kauka ('oiai, nā minuses, nā mea'ike) i kēia mau mea he'ano kūlike kēlā me ka hopena.

Ma waho a'e o ka pale'ana i ka'ōpū i makemake'ole'ia, ua'ike'ia kēia'ano lā'au lapa'au e kekahi mau mea pono'ē a'e, a, no ka helu'ana i nā'ano kūpono'ole, e'ae ana e koho i ka'ano'oi o ka hana kuhi. 'O nā ku'ikahi a pau e wehewehe i ka lā'au lā'au "Claira". Aia nā'ōlelo a ke kauka i ka'ike e pili ana i ka mea pono'ole ke lawe i kēia lā'au.

He aha ka hā'awi'ana i ka hā'awi?

Hoemi i ka nui o ka eha, a menstrualnopodobnoe kahe ana ke koko, a ultimately hiki aku ai i ka nui ka ho'ēmiʻana i loko o ka pilikia o ka hao deficiency anaemia. 'O kēia ke kumu nui o "Clayra" e ho'olako ai. 'O nā'ōlelo a nā kauka ('o nā mea a pau o kēia lā'au'ike i lalo) e hō'ike i ka ho'olako'ana i kēia mau mea a pau, a no laila ua'ōlelo'ia ka lā'au e ho'ohana pinepine'ia. I waena o nā mea'ē a'e,'ike'ia he ho'ohana nui'ana ka ho'ohana'ana i kēia lā'au lapa'au i ka hiki ke ho'omohala i ka ma'i kanemona endometrical. 'O ka lawe'ana i ka lā'au lapa'au e ho'oemi i ka hopena o ka ma'i āpau'ana.

He aha nā'ōlelo a nā kauka?

No ka lā'au'ona "Clayra",'ōlelo pinepine nā kauka i ke'ano he hopena maika'i loa ia i ka endometrium, a no laila ke ho'ohana'ia nei no ka mālama'ana i ke kahe o ka manstrual lō'ihi me ka'ole o nā ma'i pilikino. Mau symptoms i kēlā wā i kēia wā dysfunctional uterine kahe ana ke koko. 'O kēia ka mea e wehewehe ai i nā mana'o o nā kauka e pili ana i ka ho'omākaukau'ana o "Claira". Me ka li'ili'i, hiki ke ho'ohana'ia ka ho'ohana.

Huli

'O ka palekana a me ka maika'i o ka ho'ohana'ana i nā papahana estradiol i'ole ke'ano o nā ma'i e pili ana i nā hō'ailona o ka waihā o ke koko o ka'i'o me ke'ano o nā hanu'ana.

Ua ho'ohana'ia nā papahana ho'okahi a me ka ho'olālā ho'opili. I ka hopena, ua koho'ia 269 mau ma'i e ho'ohana iā Clayra. (I hoakakaia pros / Con ma ka au mamuli) Reviews o ka poe kumu, e lawe ana kekahi i loko o ke ao, i mai la ia ma ka hou ana i keia mea, ua komo nō i loko o ke ao o ka 152 nā mea maʻi, i ho'āʻo i ka hopena o ka placebo. I loko o kēia mau ha'awina, ua ho'oholo'ia e'oi aku ka maika'i loa o ka lā'au ma mua o placebo i ka mālama'ana i kēia mau hō'ailona, a he mea pono ke ho'omaopopo'ia'o ka helu hopena o ka pane i ka hua'ōlelo Claira i'oi aku i ka 40% ma kēlā me kēia o nā ha'awina.

Eia kekahi, ua hō'ike maopopo'ia kēlā me kēia o nā ha'awina a me ka hō'emi nui'ana o ka make'ana o ka manstrual, a ma hope aku ua ho'ohui pū'ia me ka nui o ka pi'i'ana o ka pae hao metabolism, i kēia manawa e ho'omaopopo'ia ana e pili ana i nā mana'o o "Claira" .

E like me ka estrogene i loko o kēia ho'omākaukau'ana, estradiol Variat,'o ia ka mea mua o nā pono 17ß-estradiol. 'O ka'eneene estrogen i ho'ohana'ia i kēia lā'au lapa'au loa e pili ana i nā estrogens i ho'ohana mau'ia i loko o nā kipikopi ākea wahala,'o ia nā'ae'a like'ole me nā mestranol a ethinylestradiol, a me nā helu o ka'āpana ethynyl i ka 17pp. Hana kēia hui i ka nui o ka pa'a o ka mīkini, akā i ka manawa like, he hana ko'iko'i no ka ate, a he mea nui loa.

Ma ka ho'ākāka'ana o ka lā'au lapa'au "Clayra",'ōlelo pinepine'ia nā loiloi kālai'ike a ua'ike'ia kāna hō'ailona ma kahi hopena li'ili'i'ole o ke ake ma ka ho'ohālikelike'ana me nā PDA'ekolu,'o ia ho'i nā levonorgestrel a ethinyl estradiol. I loko o ka noiʻi ka mea i manao ia i ke kanawai o ka lehulehu o ka globulin ke hoʻololi i ka nakinaki ia hormones, Ua emi hai. Ma ka hui pū'ana me ka vienoradioradio vale he hō'ike nui i ka HDL,'oiai ka emi'ana o ka nui o ka LDL cholesterol.

'O Dienogest he pulapula e hana ana i ka ho'oponopono waha. Hō'ike'ia kēia'ano e nā'ano anialndrogenic hapa nui, akā, he mea'ole kona mau'estrogenic, androgenic a me estrogenic. Ma muli o ke kahe hana'oko'a, ua ho'okō'ia kekahi'ano o ka hana pharmacological,'o ia ho'i nā mea nui loa o ka 19-nor-progestogen, a me nā'ano hua'ōlelo progesterone, i'ike'ia no nā mana'o hou o Claira (like me nā hui / minuses e'ōlelo'ia ma lalo nei).

'O ka'ikepili pūnaewele i loa'a i ka papa hana ma'amau i nā kumu he nui, a me nā pono hana kino a me ke kino o kēia luna,'a'ole ia i hō'ike i ka nui o ka pilikia o nā kānaka. Eia na'e, i ka wā e wehewehe ana i nā hō'ailona lā'au "Clayra" o nā kānaka palehonua,'ōlelo pinepine mākou e pono'ole iā mākou e ho'opoina e pili ana i ka hiki ke ho'ouluhua i kahi heluna a me nā mea hi'ona e hilina'i ai me nā hormones. Ma ka hihia o ka pololei pono o ka ai-kapaia Pearl Index (i ana e hoʻoholo i ke alapine (frequency) o ke hāpai keiki i loko o nā wāhine ma luna o ka haneri makahiki o ke noi ana o kekahi lāʻau) i ka waiwai emi o 1, akā, ma ka hihia o ka nalo ana o na papa io a me ka hoʻohana 'ana i ka mea hiki ke ulu.

A laila, e no'ono'o'ia nā pharmacokinetics o ke lā'au lapa'au "Clayra". 'O nā'ike e pili ana i nā kāki'oki mele e pa'a loa i ka'ike i hō'ike'ia e ka mea hana, i pili i kahi mea i kau'ia kēia mea hana no nā ma'i he nui.

'O Dienogest

• Omo. Ma hope o ka ho'oponopono'ana i ka waha, ua wikiwiki kēia māmā a aneane hiki ke ho'opau. hope e pili ana i ka hora C _max i loko o ke koko lāʻau lapaʻau kīnā ke anakahi 90,5 ng / ml ma hope o ka papa ua laweʻia (inā loaʻa 3 mg o dienogest a me 2 mg estradiol variat). 'O ka bioavailability i kēia hihia ke pi'i aku he 91%. He mea pono ke ho'omaopopo i nā kāpīpikō'au e pili ana i ka pilina o nā mea like'ole o ka 1 to 8 mg. Inā ho'ohana maika'i'ia ka lā'au lapa'au me ka'ai'ana,'a'ole kēia kumu e hopena i ka hopena o ka hopena ma muli o ke degree a i'ole ke'ano o ka lawe'ana o kēia mea.

• Hoi o ka makana. 'O kahi hapa nui o ka dienogest circulating (10%) he unbound, a'o ke koena o ia mea he hui kīnā'ole me albumin. 'A'ole pa'a pono ka Dienogest i nā corticosteroid-ho'opa'a i globulin a i'ole GSBG. No kēia kumu ke ho'opau loa'ia ka pilikia o ka ho'okomo'ana i ka testosterone mai kēia palapala ho'opa'a me GSB a i'ole cortisol mai ka ho'opa'a'ana o kēia māhele i ka CRS. 'O kēia a i'ole kēlā hopena ma nā'ano physical physics o ka holo'ana o nā steroids hopena, i kēlā me kēia, hiki'ole ke hiki. I ka wā o ka equilibrium lehulehu, he 46 V _D L like me ka hopena o intravenous hooponopono o 85 mg dienogest 'ae' ia me ka tritium.

• Pūnao. Dienogest hehee ai ua kokoke loa metabolized i piha kaʻaeʻana me ka a ianoiyuaa a ike mau alahele o ka pūnao o steroid hormones, e like me ke kahua o ka metabolites mea i loko o ka hapanui nui o na hormonally AEeOEXAaI. Ua hele wikiwiki loa kēia mau melikapila, no laila, ka hapa nui i ka plasma toto ke ko'iko'i mau loa. 'O ka pau'ana o ka'ae'ana ma hope o ka ho'oponopono ko'iko'i o ka ho'ona'auao'ana he 5.1 l / h.

• Hoʻopau. Ma muli o ka lawe'ana i kēia mehana i loko o kahi o ka 0.1 mg / kg, hiki ke kikowa'i o nā mea like me nā metabolites, i ho'oku'u'ia e nā pu'upa'a a me nā'ōpū ma kahi o ka'ōmeke 3: 1. Ma hope o ka ho'oponopono waha, kahi 42% o ka hopena i ho'opau loa'ia i ka lā mua, aia 63% - no 6 mau lā ma muli o ka ho'opi'i nui. Eia kekahi, ma hope o nā lā'eono, ma kahi o 86% o ka ma'i i ho'oku'u'ia ma o nā'ōpū a me nā pu'upa'a.

• Ka ho'opili kaulike. I kēia hihia,'a'ole i hilina'i ka po'e pharmacokinetics o ka'ike i ka mana'oo ka SHBG. Anakahi C _ss ua loaʻa ma hope ma kahi o ekolu mau lā ma hope o ka hoʻohana 'ana i ka ia mahele lāʻau, i mea 3 mg dienogest ma ka hui pu ana, me ka 2 mg Estradiol valerate.

Kūpono'o Estradiol

• Omo. Ma muli o ka ho'ohana'ana i ka neradioestradiol, wikiwiki a lawe ikaika'ia'o Varian. Ho'opili'ia i loko o ka waikawa'aiakini a pololei ka estradiol pono'ī'ia e hana'ia i ka lawe'ana o kēia māhele i ka mucosa o ka'āpana'oko'a i'ole i ka manawa o ka māhele mua i loko o ke ake, i ka hopena o ka estradiol a me kona mau kūmomo. Inā ho'ohana'ia ka lā'au lapa'au i ka manawa like me ka'ai,'a'ole loa'a ka hopena o ka hopena ma ka hō'ailona ai'ole ka lihi o ka lawe'ana o kēia māhele.

• Pūnao. 'O ka'ona Valerian ke'ano me ka wikiwiki wikiwiki. Ma hope o ka'a'ai'ana o kahi o 3% o ka hua'ōlelo, lilo ia i mea ola loa ma ke'ano o ka estradiol ma'amau, i ka hopena o ka mahele mua i loko o ke ake, a ma muli o ka hopena o ka hapa nui o ka ha'uki i ho'onohonoho'ia i loko o ka mucosa o ka'āpana o ka ma'i. I ka hui pū'ana me ka presetic metabolism i loko o ke ake, e like me 95% o ka hopena o ka hopena a pau ke ho'okomo'ia ma mua o kona komo'ana i ka'ōnaehana pūnaewele. 'Oiai ke kumu nui o ka metabolites, eia ka estrone sulfate, ka estrone a me ka glucuronide estrone.

• Hoi o ka makana. I loko o ke koko, he 38% o ka estradiol he pili kūikawā me SHBG, a 60% - me albumin, a'o 2-3% wale nō ke ka'aha'i mau i kahi noho unbound. Pono e ho'omaopopo'ia e hiki i ka estradiol ke ho'onui i ka ho'onui piha o ka SHBG i loko o ke koko, a'o kēia hopena e pili pono ana i ka loa'a i loa'a. Ma ka lā 21 o ka lawe'ana i kēia lā'au lapa'au, ua hele ka ho'opihaha piha o ka SHBG i 146% o ka ho'opi'i mua, a ma ka lā 28,'o ia ka hopena o ka papa o nā papa hana'ole, ua ho'ēmi'ia i 141%.

• Hoʻopau. No ka mea, he pono nui pūnāwai o ka hoʻolahaʻia glucuronides a me sulfates, e like me no ka mea, o ka mea hepato-enteric recirculation T _1/2 estradiol ma hope o ku una hana i loko o ka maʻi pae o ka luna 'hiʻona, pono e kaukaʻi ma luna o nā mea a pau i kēia mau keʻano o ka hanaʻana.

• Ka ho'opili kaulike. Ho'okumu pololei nā pharmacokinetics o estradiol ma ka ho'okūpa'a o SHBG. I loko o nā wāhine,'o ka mahele o ka estradiol i loko o ka plasma toto he pilikia ia o ka estradiol hopena, a me ka estradiol i komo i ke ka'ina o ka lawe'ana i kēia lā'au lā'au. I loko o ka manawa o ka lawe'ana i nā papa, kahi i loko o 3 mg o ka nui a me 2 mg o ka estradiol valerate,'o ka mahele o ka estradiol ma ke koko koko ke ho'opili'ia'o 51.6 pg / ml.

I ka manawa hea i ho'ohana'ia ai kēia lā'au lā'au?

'O ka mea mua, "Clayra" ke mālama'ia me ka menopause. 'Ōlelo nā kauka,'o ka koho kūpono loa kēia no ka ho'oma'ema'e'ana i nā wāhine e loa'a ana i ka mea ho'olālā a i'ole ka ho'omau'ana o ke koko no ka lō'ihi'ole o nā ma'i pilikino.

Ho'oma'a'ia kēia lā'au lapa'au no ka hana kū'ē'ole.

Kū'ē

No ka lā'au lā'au "Claira" hō'ike no nā kauka (hopena hopena) -'a'ole kūpono. No laila, aia kekahi mau hō'ailona. 'Ike mākou i nā kumu kūpono'ole e ho'ohana'ia ai kēia'elele, a inā ho'opau loa'ia ka hō'ailona i ka wā e ho'omaka ai kekahi o lākou e ho'omohala i ke kumu o ka lā'au:

• Ka hanana nui i nā mea hana a i'ole i kahi'āpana kōkua;
• 'O ka Thromboembolism a i'ole ka thrombosis i kēia manawa ai'ole i ka hana hana;
• Nā kūlana i kuhi mua'ia, ma ka mo'olelo a ma kēia manawa;
• Hō'ike i ka predisposition i ka hopena a i loa'a paha i ke'ano o ka'ōhū pūpū a me nā mea'eha paha, me ka hemahema o ka antithrombin III, ka hemahema o ka protein S a me C, nā pū'ali i phospholipids a hyperhomocystsinemia;
• Ka pi'i'ana o kahi pilikia nui o ka ma'i kuhi a me ka ma'i'eha;
• Ke hele'ana o ka migraine me kekahi mau hanana'ike i ka neurologic i ka manawa a me ka hana hana;
• 'O ka ma'i diabetes, i'ike'ia e nā ma'i'eha;
• Pancreatitis, me ka hypertriglyceridemia ma'amau i ka manawa a i ka hana hana paha;
• 'O ka ma'i hanu i'ole i'ole ka hanu'ana o ka ate;
• Hō'ike'ia i nā ma'i o ka hō'ino i ka hormone a i'ole i mana'o'ia no ka hopena;
• Nā ma'i nui o ka ma'i;
• 'O ka hāpai'ana a i'ole i mana'o'ia paha;
• Ka lawe'ana mai kahi pilikino o kahi i'ike'ole'ia;
• 'O ka hele'ana o ka ma'i o ka laose, ka glucose-galactose malabsorption ai'ole kahi hapa o lactase.

I waena o nā mea'ē a'e, pono e'ike i kekahi hihia'ē a'e kahi e hiki'ole ai ke ho'ohana'ia e "Claira" i nā mea hō'ole. 'Ōlelo nā kauka'a'ole pono e lawe'ia i ka manawa o ka hānai.

Nā hō'ailona kūikawā

Inā loa'a kekahi ma'i, nā kūlana a i'ole nā pilikia, i hō'ike'ia ma lalo, i kahi kanaka i kēia manawa, pono e no'ono'o pono e pili ana i ka pilikia a me ka pōmaika'i o ka lawe'ana i kēia lā'au i kēlā me kēia hihia. 'O ke'ano, pili kēia i nā'ano i lalo:

• Nā mea e pilikia ai no ka ulu'ana o ka thromboembolism a me ka thrombosis;
• 'O nā ma'i'ē a'e e'ike'ia ai nā hana'ino like'ole o ke kahe o ka'ao'ao;
• 'O Hypertriglyceridemia;
• Ke kūlana o ka mea i loa'a i ke kino;
• 'O nā ma'i'eha i'ike mua'ia a i'ole e kaumaha i ka wā o ke kōkō ai'ole i ka wā i hana mua'ia ai nā hormones.

Ma kēia mau hihia,'a'ole hiki iā'oe ke lawe i nā papa "Clayra". E kōkua nā mana'o o nā kauka i kēia kūlana e mālama i ke olakino.

'O ka'ōpū a me ka manawa o ka hānai

I ka hana o keia k ua contraindicated i hāpai keiki. Ma keia hihia, ma laila nō ia mau wahi, i hiki i ka wa a hapai ana ia lŘlŘ i loko o nā mea maʻi e loaa ana i pili pū kēia i ka lāʻau "Klayra" manual. Reviews o nā kauka e olelo aku nei i loko o keia hihia e pono e hooki koke ukali ma ka loaa. Naʻe, i loko o ka papa o ka hooko ana mai nui-unahiʻole, i haʻawina mahuahua pilikia o kekahi hanau mā i loko o na keiki i ole, ua manao, hanau i ka wahine, ka poe i ka CPC like ma mua hapai ana, a ma kā lākou mauʻaʻahuʻoluʻolu? Eaia i ka hoʻomaka o ka hāpai keiki.

CPC kekahi manawa, pili lactation, e like me ka mea, e he kūlana maikaʻiʻole i ka nui o ka waiū hua mai ai a hiki i ka hoʻololi 'ana i kona haku mele' ana, a ua pinepine i olelo ia e pili ana i ka hoomakaukau "Klayra" pane mai o na kahuna lapaau. no keia mea, ua i paipai ka oi aku ma hope o 40 makahiki kona hoʻohana.