Ke immunoglobulin G, aha mea ia no ke kanaka?

No ka kaua maʻiʻaʻai i loko o ke kanaka kino hoʻopili like me ka helu o nā kumumea. Kekahi o na wahiʻano nui i loko o kēia kaʻina pili ana i ka immunoglobulin, a no e oi kūlike loa, ka immunoglobulin G. Other ke ano o immunoglobulins, IG G ua hiki ke pale aku i ke kino o kekahi keiki pēpē mai ka maʻiʻaʻai, like i ka mea hiki ke komo iloko me ke koko o ka makuwahine o ma ke keiki, komo i ka keiki ka koko.

Ke lātoma ninoieo o IG G subunit, kona kaumaha mea e pili ana 150 kD. Ma kānaka, a me kaʻiole, hōʻike eha subclasses, i ua immunoglobulin G. lakou i loaa mua ma serological ki ina hana like. Immunoglobulin ami māhele wehewehe aku ma ka helu nui o ka cysteine residues a me ka proline lātoma, i hoʻoholo kona kohoʻia. Disulfide paa ma keia hapa o ka lātoma i kā lākou oko ao, ma muli o ka subclass globulin. Penei, gamma 1 a me ka gamma globulins 4 i mau disulfide paa ana, gamma 2 - eha Gamma 3 - he umikumamakahi. Ke gamma 1 pae ami māhele originates wale mai ka 216-la i koe, a welau a me 231-m. A ami māhele Gamma kaula 3 ke aupuni 'ma kanaha ehiku residues ma hope ma mua o 1. Gamma Study haawi'aminoʻakika kaʻina hana ka mea e hiki ai, e kuhi ana i ka like mahuahua ma residues pili me ka papalua duplication wahi 216-231 gamma 1 pae. Ke ami māhele 'āina mai ka nui singularity: hana kūleʻa ma ka mea kaumaha kaulahao elua ia lŘlŘ a me kaʻoʻoleʻa cyclic octapeptide hale, i lawelawe' ana me kuapo iho (axis) no ka mea holoʻokoʻa'ōlewa ami māhele 'āina, a me keia wahi aku no Fab-hakina i mea e pono ai, e pāʻani aku me ka ai iiiaanoaa o antigens.

Hoʻomanaʻo IG G ia lŘlŘ ma iniiaiie a kiʻekiʻe'ōnaehana paleʻea pane, e like me kēia 'ano o ka lāʻau lapaʻau kino ua like ka pono komo i loko o ka'aʻaʻa, ka mea e hoopaa ana ia a a laila wehe haole antigens.

No ka antibacterial hoomalu i loko o ke kanaka kino mākou ke pane pono immunoglobulin G. Hoʻopiʻi 'i kēia' ano o ka globulin i e ma ka hihia ma o ka'ōnaehana paleʻea'ōnaehana i, ua hiki mai i ka hui 'ana me na antigens, a hoomaka ae la konaʻeleu? Iecaianoaaiiuo o nā mea'aʻaʻa. Ke'ī mai, i ka nānāʻana aku i mea ulu i loko o ka helu o ka manawa immunoglobulins ke hoʻomaka 'eleuʻike, a me ka hana o ka maʻi i i keʻano o nā koʻohune a me nā mea hoʻomaʻi.

O ka papa kuhikuhi hana o keia 'ano immunoglobulin o ka hoomalu ana o ke kanaka kino, mai na Luna hiki ana o na la infectious maʻi. Immunoglobulin G like me ka kaua pathogens me lakou iho, a me nā huahana o ko lākou metabolic ma opsonization, phagocytosis Launch nenoai a me compliment.

Immunoglobulin G He he thymus-e kaukaʻi, i ua synthesized ma ka thymus (thymus), a me ka pololei komo o T-lymphocytes. Kēiaʻano globulin o ka papa kuhikuhiE ke keʻena, a me ka globulin hapa iki o ke koko mea ma kahi o 80% o nā ano o immunoglobulins. Ke'ī mai, i ka hiki aku o nā immunosuppressants, e like me waiū ma ka oihana i pono, e uhi i ka hoʻololi kemikala o IG G, akā, no hoi, e uhi ia pau.

Ke immunoglobulin G, i mea ka kūmau i loko o ke kino loli aʻe ke kaumaha ma muli o ka makahiki no 15 makahiki kona hope 'ilikai kīnā a me ka mea 8-17 nā huna no hano o ke koko. Ma keia hihia, e hiki no ia e ole wale i loko o ke koko, a kūhōhō ma ke kino a me ke koko, e hiki no hoi eaaei komo i loko o ka extravascular kahua, no ka hana a pau o kona mau oihana i ka immunoglobulins. Immunoglobulin G ua uniformly māhele aku nā loko o ke koko a me ka 'ē aʻe nā'aʻaʻa loko o ke kino, i laila hoʻomalu o ka meaola e kū'ē i nā mea palahēhē.