Zoledronicʻakika: pharmacological ai a me analogues

Ua ua ike ia bisphosphonates kamaʻilioʻana e inhibit i ke kūpono 'ana o ka iwi metastasis a me ka pale iwi me keia poho. Kekahi o ka mea maikai ai 'a pau a hiki i kēia pūʻulu - zoledronicʻakika. Nō hoʻi, he mea hōʻike i kēia k i angioneogenesis inhibition,ʻeho kaua, mea pīlali o kaʻeho aeee i loko o ka iwi'aʻaʻa, induces apoptosis, a me he mea synergy me ka chemotherapy.

Hoʻomanaʻo 1 hue

Zoledronicʻakika monohydrate - 4,26 mg Excipients - paʻakai citrate, D-mannitol.

pharmacology

An inhibitor o ka iwi resorption. Zoledronicʻakika no i ka hou papa o ke kiʻekiʻe ka papa o bisphosphonates. Ua loaʻa he e wae ia ma ka iwi. Ho'ēmi i kā ka ha awina o osteoclasts, me ka hoohele i ka hopena maikaʻi ia ma luna o ke kahua a me nā ano o ka iwi'aʻaʻa. Ka hopena o ka bisphosphonates ma ka iwi ua nānā 'ana ma luna o ka similarity kiʻekiʻe i mineralized iwi, akā, i ka kūlike loaʻano papa hana o nā lātoma e hoʻolako inhibiting i ka ha awina o osteoclasts, a hiki i kēia lā nō i ole, ua? Anoee. Nō hoʻi ia i ka pololei Anati-ʻeho ka waiwai, kaulike ka hoʻokōʻana i ka iwi metastasis.

I lūmaua loaʻa i zoledronicʻakika, induces apoptosis a inhibiting ka hoʻonuiʻana o nā keena me ka antitumor ia 'ana ma luna o myeloma, e like me ka maʻi' aʻai keena o ka umauma, oiai e hoemi i ka pilikia o ka metastasis. Nō hoʻi, zoledronicʻakika i ka waiwai o ka hoemi i ke kalipuna lehulehu ma ka lāʻau lapaʻau hypercalcemia, a ua kauoha ia e kaʻeho.

nāʻikepili

• Osteolytic lesions i mau myeloma foci.
• Osteoblastic, osteolytic i hui iwi metastasis o ka nui hikoko.
• Hypercalcemia, a ua kauoha aku ma ka malignancy.

Contraindications

• Hāpai keiki a me ka umauma-e ai ana.
• ʻaʻa puʻuwai insufficiency.
• Keiki a me nā adolescents (noi mālama 'ia hoʻi i ole, ua hookupaaia).
• Hypersensitivity i bisphosphonates a me zoledronicʻakika.
• Kaiapuni:ʻaʻa puʻuwai dysfunction, bronchial asthma, hepatic ole.

ʻaoʻao waiwai

Anemia, thrombocytopenia, headache, pōniuniu, conjunctivitis, nausea, anorexia, ka luaʻi, diarrhea, iwi eha, arthralgia, hypophosphatemia, hypocalcemia, kuni, maʻi palū maʻi pale, luhi, kaumaha o koʻu pomaikai ia. Ma ka iapaau ana o nā mea maʻi me ka zoledronicʻakika ua i kekahi manawa, malama (IeAUPIIe, IAa IO hope kahua nihoʻoki lāʻau lapaʻau 'uao) i ka hooulu ana o ka osteonecrosis o ka iwi ā.

Dosing

Intravenous drip, a me loko o 15 minuke, akā,ʻaʻohe emi. Metastases o mau myeloma paipai mahele lāʻau o ka 4 mg hookahi i ka mahina. I ka hypercalcemia, a ua kauoha ia e ka malignantʻeho, he mahele lāʻau o ka 4 mg hookahi kela la i keia.

Cautions

Once ka lāʻau lawelawe iho la no, ia mea e pono ai i kū i ka lehulehu o ka makanekiuma, phosphorus, creatinine a me ka kalipuna i loko o ke koko lāʻau lapaʻau. Inā hiki, e ua? Aeiiaiaoaony e pale kahua nihoʻoki kino.

Zoledronicʻakika. analogs

Ai ' "Actonel", "Aneldronat", "Areda lyophilisate", "Bonviva", "Bondronat", "Bonefos", "Klobir", "ksidifon", "Lindron", "Ostalon", "Ostealen", "Osterepar" "Pamidronate", "Pomegara", "Rizendros", "Strongos", "Tevanat", "Foroza" "Fosamax", "Fosfoteh", "Rizarteva".

Zoledronicʻakika. kuai

Nō kāu, kahua komo i loko o ka puunaue ana o laau lapaau i loko o ke kanawai, hoike lakou i ke kala no kā lākou waiwai a pau. Akā, oddly lawa, ke kumukuai o ka zoledronicʻakika ua ana i hōʻike o ka hola. Akā, He kokekau wale kona waiwai ma kahi o 14 tausani rubles no mole ihoiho. Kuai i keʻena kūʻai lāʻau lapaʻau e kuhikuhi wale.

Ka luna 'ike ua manaoia e familiarize ola hana. He 'atikala mea e pili ana zoledronicʻakika' aʻole e puku palapala hōʻoia no aʻo o ke kauka, a ua hiki ole haawi aku i kekahi kumu o ka maikaʻi ia, mai ka hana ana o ka lāʻau.